Getting in early: primary skin cancer prevention at 55 German kindergartens

Stöver, L. A.; Hinrichs, B.; Petzold, U.; Kuhlmei, H.; Baumgart, Janine; Parpart, C.; Rademacher, O.; Stockfleth, Eggert

doi:10.1111/j.1365-2133.2012.11088.x

Cited by 26 publications

(35 citation statements)

References 34 publications

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“…Several campaigns for sun protection and skin cancer prevention for children have been developed in different countries of the world, showing very favourable results in education and awareness towards the sun …”

Section: Discussionmentioning

confidence: 99%

“…Between 50% and 80% of a person's cumulative lifetime, sun exposure occurs before the age of 18 years . Sun exposure in childhood and intense intermittent sun exposure are the major environmental risk factors for the development of melanoma, while the chronic exposure has been associated with the occurrence of non‐melanoma skin cancer (NMSC) . Stern et al .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Sun exposure in childhood and intense intermittent sun exposure are the major environmental risk factors for the development of melanoma, while the chronic exposure has been associated with the occurrence of non-melanoma skin cancer (NMSC). 9 Stern et al 7 showed that an appropriate sunprotective behaviour during childhood could lower the incidence of NMSC by nearly 80%.…”

Section: Introductionmentioning

confidence: 99%

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Skin cancer prevention campaign in childhood: survey based on 3676 children in Brazil

Criado

Ocampo‐Garza

Brasil³

et al. 2017

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Skin cancer prevention campaign in childhood: survey based on 3676 children in Brazil

Criado

Ocampo‐Garza

Brasil³

et al. 2017

Acad Dermatol Venereol

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“…Neoplasms of the skin represent the most common type of cancer in fair-skinned populations, and incidence rates of nonmelanoma skin cancer (NMSC), including both basal cell (BCC) and squamous cell carcinoma (SCC), are increasing worldwide [1–3]. Solar UV photons are established environmental carcinogens, and NMSC incidence correlates with high cumulative solar exposure [1, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Williams

Bermudez

Park

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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Cutaneous exposure to solar ultraviolet radiation (UVR) is a causative factor in photoaging and photocarcinogenesis. In human skin, oxidative stress is widely considered a key mechanism underlying the detrimental effects of acute and chronic UVR exposure. The lipid peroxidation product malondialdehyde (MDA) accumulates in tissue under conditions of increased oxidative stress, and the occurrence of MDA-derived protein epitopes, including dihydropyridine-lysine (DHP), has recently been substantiated in human skin. Here we demonstrate for the first time that acute exposure to sub-apoptogenic doses of solar simulated UV light (SSL) causes the formation of free MDA and protein-bound MDA-derived epitopes in cultured human HaCaT keratinocytes and healthy human skin. Immunohistochemical staining revealed that acute exposure to SSL is sufficient to cause an almost twenty-fold increase in general MDA- and specific DHP-epitope content in human skin. When compared to dose-matched solar simulated UVA, complete SSL was more efficient generating both free MDA and MDA-derived epitopes. Subsequent tissue microarray (TMA) analysis revealed the prevalence of MDA- and DHP-epitopes in nonmelanoma skin cancer (NMSC). In squamous cell carcinoma tissue, both MDA- and DHP-epitopes were increased more than three-fold as compared to adjacent normal tissue. Taken together, these date demonstrate the occurrence of MDA-derived epitopes in both solar UVR-exposed healthy human skin and NMSC TMA tissue; however, the potential utility of these epitopes as novel biomarkers of cutaneous photodamage and a functional role in the process of skin photocarcinogenesis remain to be explored.

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“…children with a history of sunburn show increased risk for developing skin cancer as an adult) and etiological understanding of the gene by environment interactions (e.g. fair skinned individuals living in environments with high degree of UV exposure from sunlight) has led to high impact prevention strategies: aggressive use of sunscreen and protective clothing, particularly in high risk (fair skin) children living in high-risk environments (Corbyn, 2014; Kuhlmei et. al.…”

mentioning

confidence: 99%

Multi-Level Models of Internalizing Disorders and Translational Developmental Science: Seeking Etiological Insights that can Inform Early Intervention Strategies

Allen

Dahl

2015

J Abnorm Child Psychol

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This commentary discusses the articles in this special section with an emphasis on the specific utility of multivariate, multi-level models in developmental psychopathology for ultimately contributing to both etiologic insights and translational advances. These issues are considered not only in terms of the specific papers, but also within a larger set of questions regarding the opportunities (and challenges) currently facing the field. We describe why we believe this an exciting time for integrative team-science approaches to tackle these challenges—a time that holds great promise for rapid advances in integrative developmental science that includes a biological level of mechanistic understanding. In order to facilitate this, we outline a range of approaches within both translational neuroscience and translational developmental science that can be used as frameworks for understanding how such research can provide etiologic insights regarding real-world targets at the level of social, behavioral, and affective processes that can be modified during key developmental windows of opportunity. We conclude that a “construct validity” framework, where biological data form a critical, but not privileged, component of key etiological mechanisms, combined with a developmental perspective on key period of sensitivity to intervention effects, is most likely to provide significant translational outcomes.

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Getting in early: primary skin cancer prevention at 55 German kindergartens

Cited by 26 publications

References 34 publications

Skin cancer prevention campaign in childhood: survey based on 3676 children in Brazil

Skin cancer prevention campaign in childhood: survey based on 3676 children in Brazil

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue

Multi-Level Models of Internalizing Disorders and Translational Developmental Science: Seeking Etiological Insights that can Inform Early Intervention Strategies

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