Gestational Gigantomastia in the Setting of Myasthenia Gravis

Abstract

She did her postgraduation from the prestigious Sawai Man Singh Medical College, Jaipur. She has presented papers and posters in various national and international conferences and won awards for the same. She has keen interest in academic research of clinical significance.

Lessons learned in severe axillary gestational gigantomastia

“…Hypertrophied axillary breast tissue during pregnancy can be diagnosed as GG if growth has been rapid and incapacitating, as was the case in our patient 3 . Although the etiology of GG is not well‐established, it has been associated with hormonal hypersensitivity, hyperprolactinemia, and autoimmune disorders, although most patients do not have abnormal bloodwork 2,7,9,10 . Pedicled lipoma is less likely because it is primarily unilateral and less responsive to hormonal stimulation 11 .…”

“…3 Although the etiology of GG is not well-established, it has been associated with hormonal hypersensitivity, hyperprolactinemia, and autoimmune disorders, although most patients do not have abnormal bloodwork. 2,7,9,10 Pedicled lipoma is less likely because it is primarily unilateral and less responsive to hormonal stimulation. 11 Malignancy is rare but should be ruled out in all patients with imaging.…”

Idiopathic gigantomastia exacerbated during pregnancy. Its relationship with autoimmunity: A case report

“…Its direct relationship with pregnancy and, in some cases, with puberty, allows us to hypothesize a hormonal etiology 1 . The association of gigantomastia with diverse autoimmune diseases, such as myasthenia gravis, 8 systemic lupus erythematosus, 9 rheumatoid arthritis, 10 autoimmune thyroiditis 11 and the presence of autoantibodies, 12 supports the possibility of a role of autoimmunity. Our patient had autoimmune thyroiditis, autoantibodies and a family history of autoimmunity and presented with 1 crisis of the disease related to pregnancy and 2 unrelated to it, which makes us assume a different condition with purely hormonal effects.…”

Gestational Gigantomastia: Case Report and Review of Treatment Options

“…There have been case reports suggesting an association with certain medications (such as penicillamine [2,3], bucillamine [4,5], cyclosporine [6], prednisolone [7], and cortisone [8]). Some case reports have demonstrated gigantomastia in patients with pre-existing autoimmune conditions such as myasthenia gravis [9], systemic lupus erythematosus [10], chronic arthritis, or thyroiditis [11]. However, many cases of gigantomastia are idiopathic.…”