Gestational diabetes mellitus/hyperglycaemia during pregnancy in Poland in the years 2010–2012 based on the data from the National Health Fund

Wierzba, Waldemar; Śliwczyński, Andrzej; Karnafel, Waldemar; Bojar, Iwona; Pinkas, Jarosław

doi:10.5603/gp.a2017.0046

Cited by 7 publications

(8 citation statements)

References 10 publications

(14 reference statements)

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“…In our group of 563 participants (in the current analysis), the frequency of the pregnancy outcomes (8.4% of the deliveries were <37th week; 8.5% of the women gave birth to newborn <10th percentile, and 11.4% gave birth to newborn >90th percentile) was close to the frequency in other Polish studies [43,44]. In our analysis, the frequency of main complications (21.3% of the women have developed PIH and 19.5% have developed GDM) was about 2-4 times higher compared to the frequency in several Polish studies [43,45,46]. At the same time, among our participants, 40.7% of the women were primiparous, 39.1% had prepregnancy BMI ≥25 kg/m 2 , and 63.6% were ≥35 years.…”

Section: Discussionsupporting

confidence: 80%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels.

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Section: Discussionsupporting

confidence: 80%

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Lewandowska

Więckowska

Sajdak³

et al. 2020

Nutrients

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“…Prevalence of GDM in the study was higher than in general polish population, what can be explained by higher referentiality of our centres in comparison to general population. Regardless the stage of referentiality authors emphasise increasing trends in diagnosis of gestational diabetes over the last decade from 9.61% at the beginning of the study to 15.27% in 2019 what is consistent with temporal trends in other countries [21,22]. Although GDM is well known risk factor of foetal macrosomia in our cohort there was no significant difference of prevalence of GDM in mothers of macrosomic infants comparing to other infants, what is also consistent with some studies [23,24].…”

Section: Discussionsupporting

confidence: 91%

“…The incidence of GDM worldwide varies from 1 to 45% of pregnant women depending on studied population [21]. Among the Polish population, prevalence of GDM based on National Health found that in 2012 it was estimated as 7.45%, and the trend of its incidence was increasing [22]. In our study analysis of medical records in total revealed 10.61% of mothers diagnosed with gestational diabetes.…”

Section: Discussionmentioning

confidence: 48%

Foetal macrosomia — incidence, determinants and neonatal outcomes: 10-years retrospective review, 2010–2019

Buraczewska

Bonin²,

Meyer-Szary³

et al. 2023

Ginekol Pol

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“…GDM affects an estimated 1–14% of pregnant women, depending on ethnicity and the diagnostic criteria applied [ 2 ]. In Poland, the prevalence of GDM was reported as 7.49% in 2012 in a study using the diagnostic criteria set by the World Health Organization (WHO)/International Association of Diabetes and Pregnancy Study Groups (IADPSG), with the cutoffs of >90 mg/dL for fasting plasma glucose (FPG) concentration and of ≥140 mg/dL for 2 h plasma glucose concentration at a 75 g oral glucose tolerance test (OGTT) [ 3 ]. Of great concern, GDM associates with an increased incidence of complications in both the mother (e.g., gestosis, urinary tract infections, cesarean sections and perinatal injuries) and the fetus (e.g., macrosomia, hypoglycemia, and cardiomyopathy) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Dysregulation of Inflammation-Related Genes in Leukocytes of Patients with Gestational Diabetes Mellitus (GDM) during and after Pregnancy: Identifying Potential Biomarkers Relevant to Glycemic Abnormality

Zieleniak

Źurawska-Kliś

Cypryk

et al. 2022

IJMS

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Although the immune system has been implicated in the pathophysiology of gestational diabetes mellitus (GDM) and postpartum abnormal glucose tolerance (AGT), little is known about the transcriptional response of inflammation-related genes linked to metabolic phenotypes of GDM women during and after pregnancy, which may be potential diagnostic classifiers for GDM and biomarkers for predicting AGT. To address these questions, gene expression of IL6, IL8, IL10, IL13, IL18, TNFA, and the nuclear factor κB (NFκB)/RELA transcription factor were quantified in leukocytes of 28 diabetic women at GDM diagnosis (GDM group) and 1-year postpartum (pGDM group: 10 women with AGT and 18 normoglycemic women), using a nested RT-PCR method. Control pregnancies with normal glucose tolerance (NGT group; n = 31) were closely matched for maternal age, gestational age, pre-pregnancy BMI, pregnancy weight, and gestational weight gain. Compared with the NGT group, IL8 was downregulated in the GDM group, and IL13 and RELA were upregulated in the pGDM group, whereas IL6, IL10, and IL18 were upregulated in the GDM and pGDM groups. The TNFA level did not change from pregnancy to postpartum. Associations of some cytokines with glycemic measures were detected in pregnancy (IL6 and RELA) and postpartum (IL10) (p < 0.05). Receiver operating characteristic (ROC) curves showed that IL6, IL8, and IL18, if employed alone, can discriminate GDM patients from NGT individuals at GDM diagnosis, with the area under the ROC curves (AUCs) of 0.844, (95% CI 0.736–0.953), 0.771 (95% CI 0.651–0.890), and 0.714 (95% CI 0.582–0.846), respectively. By the logistic regression method, we also identified a three-gene panel (IL8, IL13, and TNFA) for postpartum AGT prediction. This study demonstrates a different transcriptional response of the studied genes in clinically well-characterized women with GDM at GDM diagnosis and 1-year postpartum, and provides novel transcriptomic biomarkers for future efforts aimed at diagnosing GDM and identifying the high risk of postpartum AGT groups.

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Gestational diabetes mellitus/hyperglycaemia during pregnancy in Poland in the years 2010–2012 based on the data from the National Health Fund

Cited by 7 publications

References 10 publications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

Foetal macrosomia — incidence, determinants and neonatal outcomes: 10-years retrospective review, 2010–2019

Transcriptomic Dysregulation of Inflammation-Related Genes in Leukocytes of Patients with Gestational Diabetes Mellitus (GDM) during and after Pregnancy: Identifying Potential Biomarkers Relevant to Glycemic Abnormality

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