Geroscience approaches to increase healthspan and slow aging

Melov, Simon

doi:10.12688/f1000research.7583.1

Cited by 22 publications

(17 citation statements)

References 109 publications

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“…However, we show here that this is not necessarily the case. Our study, which incorporates comprehensive, lifelong measurements and an integrated definition of overall health (both suggested to be critical factors for such an analysis (Melov, 2016)), shows similar results in a genetically identical, wild-type population. Specifically, we observe a continuum in which the fraction of lifespan spent in good health systematically diminishes from short- to long-lived individuals.…”

Section: Discussionsupporting

confidence: 58%

“…Thus the daf-2 mutant likely departs from the relationship between long life and extended fractional gerospan that we have characterized. Our longitudinal approach now allows for a more detailed understanding of how health integrates across physiological systems and evolves over time in different genetic backgrounds, filling a previously unmet experimental need (Melov, 2016). Future studies with these approaches promise to unravel the complex relationship between the plasticity of different phases of senescence and lifespan extension in general.…”

Section: Discussionmentioning

confidence: 99%

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Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health

et al. 2016

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Summary Although many genetic factors and lifestyle interventions are known to affect the mean lifespan of animal populations, the physiological variation displayed by individuals across their lifespans remains largely uncharacterized. Here, we use a custom culture apparatus to continuously monitor five aspects of aging physiology across hundreds of isolated Caenorhabditis elegans individuals kept in a constant environment from hatching until death. Aggregating these measurements into an overall estimate of senescence, we find two chief differences between longer- and shorter-lived individuals. First, though long- and short-lived individuals are physiologically equivalent in early adulthood, longer-lived individuals experience a lower rate of physiological decline throughout life. Second, and counter-intuitively, long-lived individuals have a disproportionately extended “twilight” period of low physiological function. While longer-lived individuals experience more overall days of good health, their proportion of good to bad health, and thus their average quality of life, is systematically lower than that of shorter-lived individuals. We conclude that within a homogeneous population reared under constant conditions, the period of early-life good health is comparatively uniform and the most plastic period in the aging process is end-of-life senescence.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health

et al. 2016

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“…28 In the current concept paper, we propose the P4 Health (P4H) continuum model, which embraces and expands upon the concepts of P4 medicine 24 , as a framework to promote and facilitate pro-active collaborations with a common orchestrated language and integrated care model. This framework draws upon a number of concepts that have been previously established 25,[29][30][31][32][33] , brought together in a way that augments the potential impact.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan

Sagner

McNeil

Puska

et al. 2017

Progress in Cardiovascular Diseases

198

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Chronic diseases (i.e., Noncommunicable Diseases), mainly cardiovascular disease, cancer, respiratory diseases and type-2-diabetes, are now the leading cause of death, disability and diminished quality of life on the planet. Moreover, these diseases are also a major financial burden worldwide, significantly impacting the economy of many countries. Healthcare systems and medicine have progressively improved upon the ability to address infectious diseases and react to adverse health events through both surgical interventions and pharmacology; we have become efficient in delivering reactive care (i.e., initiating interventions once an individual is on the verge of or has actually suffered a negative health event). However, with slowly progressing and often 'silent' chronic diseases now being the main cause of illness, healthcare and medicine must evolve into a proactive system, moving away from a merely reactive approach to care. Minimal interactions among the specialists and limited information to the general practitioner and to the individual receiving care lead to a fragmented health approach, non-concerted prescriptions, a scattered follow-up and a suboptimal cost-effectiveness ratio. A new approach in medicine that is predictive, preventive, personalized and participatory, which we label here as "P4" holds great promise to reduce the burden of chronic diseases by harnessing technology and an increasingly better understanding of environment-biology interactions, evidence-based interventions and the underlying mechanisms of chronic diseases. In this concept paper, we propose a 'P4 Health Continuum' model as a framework to promote and facilitate multi-stakeholder collaboration with an orchestrated common language and an integrated care model to increase the healthspan.

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“…However, at the same time, this healthcare-mediated increase in lifespan is doing so at the sacrifice of the healthspan (ie, the number of years a person is healthy and free of disease). [7,8] There is now broad recognition that preventing unhealthy lifestyle and associated physiologic characteristics from ever occurring is the global way forward to prevent and reduce the burden of chronic disease. In fact, there is clear evidence that the vast majority of chronic diseases can be prevented or delayed to a significantly later time in the lifespan by appropriate interventions.…”

Section: Progress In Preventive Medicinementioning

confidence: 99%