2016
DOI: 10.1016/j.cels.2016.09.003
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Abstract: Summary Although many genetic factors and lifestyle interventions are known to affect the mean lifespan of animal populations, the physiological variation displayed by individuals across their lifespans remains largely uncharacterized. Here, we use a custom culture apparatus to continuously monitor five aspects of aging physiology across hundreds of isolated Caenorhabditis elegans individuals kept in a constant environment from hatching until death. Aggregating these measurements into an overall estimate of se… Show more

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Cited by 80 publications
(165 citation statements)
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“…(2015) and Hahm et al. (2015) did not include intermediate movement phenotypes, but other recent studies observed that an extended intermediate movement behavior was characteristic of both long‐lived mutants as well as long‐lived worms in wild‐type background (Churgin et al., 2017; Podshivalova et al., 2017; Zhang et al., 2016). Zhang et al.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…(2015) and Hahm et al. (2015) did not include intermediate movement phenotypes, but other recent studies observed that an extended intermediate movement behavior was characteristic of both long‐lived mutants as well as long‐lived worms in wild‐type background (Churgin et al., 2017; Podshivalova et al., 2017; Zhang et al., 2016). Zhang et al.…”
Section: Discussionmentioning
confidence: 99%
“…Zhang et al. (2016) referred to this phenotype as “extended twilight” and Churgin et al. (2017) called the phenomena “decline then plateau” wherein long‐lived animals undergo rapid functional decline, then plateau.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, mutations that extend lifespan might be expected to likewise extend healthspan. Recent studies in Caenorhabditis elegans indicate that, relative to wild-type animals, mutations that extend lifespan do indeed extend the period of youthfulness, in which animals are motile and resistant to bacterial infection (healthspan), but also extend the period of decrepitude or frailty, where animals are relatively immobile (5,6) Other studies in C. elegans that take into account multiple measures of health, each normalized to maximal lifespan, indicate that mutations or conditions that extend lifespan minimally impact or even reduce healthspan, depending on the particular measure; however, all long-lived mutants increased the proportion of time spent in a frail state (1). Together, these data suggest that a comprehensive assessment of healthspan requires evaluation of survival curves together with additional criteria such as motility, tolerance to stressors, stem cell resilience, and fecundity, among others (3).…”
mentioning
confidence: 99%
“…6 To validate the general utility of these methods for comparisons between different populations, or between different culture regimes, we examined whether this system alters key aspects of C. elegans physiology. It is well known that the health and lifespan of C. elegans are highly dependent on culture conditions.…”
Section: Resultsmentioning
confidence: 99%
“…This work describes in detail our new culture system, which we previously employed to analyze the relationship between health and lifespan among wild-type C. elegans . 6 …”
Section: Introductionmentioning
confidence: 99%