Germline stem cells: stems of the next generation

Yuan, Hebao; Yamashita, Yukiko

doi:10.1016/j.ceb.2010.08.013

Cited by 22 publications

(17 citation statements)

References 70 publications

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“…C) by the SV cells; “light blue outlined by gray” in Fig. C), and (c) its location at the terminal end of the tubular structure in the testis . Moreover, this study shows that some of SV cells are still capable of proliferation in the adult stage and then appear to contribute to the Sertoli cells within the convoluted seminiferous epithelia (Fig.…”

Section: Discussionmentioning

confidence: 60%

“…Much of our understanding regarding the mechanism of maintenance of the germline stem cells is derived from the gonads of two invertebrate organisms, Drosophila melanogaster and Caenorhabditis elegans . Although the testicular architecture is different in these species, the germline stem cells are housed similarly in a defined niche environment, which is restricted to the terminal segment of the tubular structure populated by specialized somatic cell structures such as “hub cells” in Drosophila and “distal tip cells” in C. elegans . It has been shown that in this tubular end, specialized somatic cells provide the necessary cues for stem cell maintenance to the closest germ line stem cells in addition to repressing their differentiation via short‐ and long‐range signaling factors, including TGFβ‐like signaling molecules .…”

Section: Introductionmentioning

confidence: 99%

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A Niche for GFRα1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes

et al. 2015

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In invertebrate species such as flies and nematodes, germline stem cells are maintained in a niche environment, which is restricted to the terminal end of the tubular structure in the gonads. In mice, spermatogonial stem cells (SSCs), a subpopulation of A single GFRa1 (glial cell line-derived neurotrophic factor [GDNF] family receptor-a1)-positive spermatogonia, are widely distributed along the longitudinal axis in the convoluted seminiferous tubules, preferentially juxtaposed to the interstitial vasculature. However, whether this area is the only SSC niche is not known. In this study, we identified a valve-like terminal segment of the seminiferous tubules, the Sertoli valve (SV), adjacent to the rete testis as another niche for GFRa1-positive spermatogonia in hamsters. Here, we show that the SV epithelium is composed of the modified Sertoli cells that are still capable of proliferation and missing most spermatogenic activities in the adult stage. The SV epithelium constitutively expresses GDNF, a major niche factor for SSCs, and supports the stable proliferation and selective maintenance of an A single subpopulation of GFRa1-positive spermatogonia in hamsters. The SV region of hamster seminiferous tubules has features that are similar to the stem cell niche in invertebrate gonads. Therefore, we propose that the SV may be a novel niche for A single GFRa1-positive spermatogonia potentially including a SSC population, at the terminal segments of the seminiferous tubules in hamsters. STEM CELLS 2015;33:2811-2824 SIGNIFICANCE STATEMENTIn the terminal end of the seminiferous tubules of mammalian testes, we have identified the "Sertoli valve niche" as another potential niche for spermatogenic stem cells that is similar to the invertebrate "germline stem cell niche". We here show that Sertoli valve cells are still capable of proliferation in the adult stage and then contribute to the Sertoli cells within the convoluted seminiferous epithelia (i.e., adult Sertoli progenitor cells). The Sertoli valve epithelium constitutively expresses GDNF, a major niche factor for SSCs, and supports the stable proliferation and selective maintenance of an Asingle subpopulation of GFRa1-positive spermatogonia including SSCs. We propose that the Sertoli valve epithelium is another SSCs niche at the terminal segment of the seminiferous tubules in mammalian testes.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

A Niche for GFRα1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes

et al. 2015

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“…Besides identification of signals and mechanisms involved in stem cell maintenance and differentiation, these studies have also revealed mechanisms underlying stem cell and niche interaction, essential for maintenance of healthy stem cell populations (Losick et al, 2011; Pearson et al, 2009; Hsu et al, 2014; Gunage et al, 2014; Yuan and Yamashita, 2010; Lin, 2002; Singh et al, 2007; Inaba et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

Dey

Ramesh

Chugh

et al. 2016

eLife

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Drosophila hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in Drosophila, the larval lymph gland with its Hedgehog dependent progenitors served as an invertebrate model of progenitor biology. Employing lineage-tracing analyses, we have now identified Notch expressing HSCs in the first instar larval lymph gland. Our studies clearly establish the hierarchical relationship between Notch expressing HSCs and the previously described Domeless expressing progenitors. These HSCs require Decapentapelagic (Dpp) signal from the hematopoietic niche for their maintenance in an identical manner to vertebrate aorta-gonadal-mesonephros (AGM) HSCs. Thus, this study not only extends the conservation across these divergent taxa, but also provides a new model that can be exploited to gain better insight into the AGM related Hematopoietic stem cells (HSCs).DOI: http://dx.doi.org/10.7554/eLife.18295.001

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“…Multipotent stem cells have the ability to self renew and develop into multiple tissues or differentiated cell types, such as hematopoietic progenitor cells that develop into different types of blood cells (Seita and Weissman, 2010;Wright, 1981). Unipotent stem cells have the ability to self renew and develop into one tissue type or differentiated cell type, such as the germline stem cells in the adult gonad (Brown and Swalla, 2007;Yuan and Yamashita, 2010). Fig.…”

Section: Evolutionary Cell Lineage Modification Modelsmentioning

confidence: 99%

Evolution and development of budding by stem cells: Ascidian coloniality as a case study

Brown

Swalla

2012

Developmental Biology

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The evolution of budding in metazoans is not well understood on a mechanistic level, but is an important developmental process. We examine the evolution of coloniality in ascidians, contrasting the life histories of solitary and colonial forms with a focus on the cellular and developmental basis of the evolution of budding. Tunicates are an excellent group to study colonial transitions, as all solitary larvae develop with determinant and invariant cleavage patterns, but colonial species show robust developmental flexibility during larval development. We propose that acquiring new stem cell lineages in the larvae may be a preadaptation necessary for the evolution of budding. Brooding in colonial ascidians allows increased egg size, which in turn allows greater flexibility in the specification of cells and cell numbers in late embryonic and pre-metamorphic larval stages. We review hypotheses for changes in stem cell lineages in colonial species, describe what the current data suggest about the evolution of budding, and discuss where we believe further studies will be most fruitful.

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Germline stem cells: stems of the next generation

Cited by 22 publications

References 70 publications

A Niche for GFRα1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes

A Niche for GFRα1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes

Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

Evolution and development of budding by stem cells: Ascidian coloniality as a case study

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