German S3 guidelines: anal abscess and fistula (second revised version)

Ommer, A.; Herold, Alexander; Berg, E.; Fürst, Alois; Post, Stefan; Ruppert, R.; Schiedeck, Thomas; Schwandner, O.; Strittmatter, Beate

doi:10.1007/s00423-017-1563-z

Cited by 95 publications

(125 citation statements)

References 70 publications

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“…6). Häufig findet sich in der Vorgeschichte eine Abszedierung [10,11]. Die Schmerzen sind dabei v. a. auf einen Ventilmechanismus zurückzuführen: Durch intermittierende Abflussbehinderung kommt es zu einem schmerzhaften Sekretstau, der nach meist auftretender Spontanperforation wieder verschwindet.…”

Section: Symptomatik Und Diagnostikunclassified

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Abszesse, Analfistel, Analfissur

Ommer¹,

Schneider²

2019

Allgemein- und Viszeralchirurgie up2date

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Section: Symptomatik Und Diagnostikunclassified

“…Die postoperative Nachsorge nach Analchirurgie ist einfach [11]: Es ist anhand der Schnittführung Sorge zu tragen, dass sich die äußere Drainageöffnung nicht vorzeitig verschließt. Eine regelmäßige Tamponade der Wunde bietet keinen Vorteil für die Wundheilung.…”

Section: Perioperatives Management Nachbehandlung Komplikationenunclassified

Abszesse, Analfistel, Analfissur

Ommer¹,

Schneider²

2019

Allgemein- und Viszeralchirurgie up2date

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“…The basis of the modern concept of pharmacotherapy AF [4,6] is the use of drugs, such as calcium antagonists, nitrates, botulotoxin, whose action is aimed at eliminating the hypertonicity of the internal anal sphincter (IAS), which is the main factor in the chronicization of the pathological process [5,7].…”

Section: Pharmacology Toxicology and Pharmaceutical Sciencementioning

confidence: 99%

“…Thus, the analysis of the modern range of medicines in the Ukrainian pharmaceutical market shows a complete lack of drugs, the composition and effect of which would correspond to new approaches to medical treatment of AF [4,6]. Taking into account the above, the development and introduction into clinical practice of drugs of Ukrainian origin, which would be able to influence the main pathogenesis pathways and main clinical manifestations of AF, is one of the most urgent tasks of pharmacology and coloproctology.…”

Section: Pharmacology Toxicology and Pharmaceutical Sciencementioning

confidence: 99%

Experimental Approval of the Efficacy of the Combined Composition Rectal Cream New Test-Samples in the Conditions of Acute Complicated Anal Fissure in Rats

Zaychenko

Stakhorska

2019

EUREKA: Health Sciences

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Anal fissure (AF) is one of the most common anorectal problems. The severity of the disease, the chronicity of the pathological process and frequent complications lead to a sharp deterioration in the quality of life of patients. An important place in the treatment of anal fissure is occupied by drugs that affect its key mechanism of pathogenesis, namely, reduce the muscle tone of the internal anal sphincter and have anti-inflammatory, analgesic, and reparative properties. Aim: conducting of screening studies of the effectiveness of new test samples of rectal cream of the combined composition (RCCC) on the model of acute complicated anal fissure in rats and determining the optimal composition of the potential drug. Materials and methods. The research was conducted on the basis of the Central Scientific Research Laboratory of the National Pharmaceutical University (CSRL NUPH) in the spring (April) season of 2015 on the female rats. A study of test specimens of the rectal cream of the combined composition was performed on a modified model of acute anal fissure. The effectiveness of the treatment was evaluated in terms of (0 to 2) severity of edema, hyperaemia, local bleeding, purulent necrotic processes, scapular formation, anatomical defect, and a general indicator of the severity of the pathological process (by the sum of the points for all the criteria that were analyzed). The level of proinflammatory PGE2 in serum was determined by the immune enzyme method. Results. The RCCC sample No. 4 showed the most expressive therapeutic effect among the four samples under study, and had credible benefits to the inhibitory effect on purulent-necrotic processes, as expressed by the differences in the overall rate of the pathological process (6 days: 5.83±0.47 points against 7.00±0.37; 7.83±0.31 under the influence of RCCC No. 2, No. 3, respectively, and for 11 days 5.00±1.03 versus 6.83±1.28 points (p=0.08) under the influence of RCCC No. 1). The ability of RCCCs No. 1 and No. 4 to reduce the level of pro-inflammatory PGE2 in blood serum of rats compared with CP in 1.8 and 2.0 times, respectively, contributed to accelerating epithelization and scar formation. The advantages of RCCC No. 4 on the comparison of the ointment "Proctozan" with the reduction of the period of epithelization of the defect of the mucous membrane of the anal canal for 3 days (for 7 days-RCCC No. 4, for 10 days-ointment "Proctozan"). Conclusions. The rectal cream of the combined composition No. 4 showed the greatest efficacy, had advantages over the comparison ointment "Proctozan", and is promising for the creation on its basis a new drug for the treatment of anal fissures.

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“…In den 2011 vorgestellten Leitlinien wurden die in der Literatur beschriebe-nen Operationsverfahren erstmals für Deutschland in eine wissenschaftlich fundierte Empfehlung zusammengefasst [1,5]. Diese wurde im Jahr 2016 überarbeitet [3,4]…”

Section: Analfistelnunclassified

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Ommer

2019

coloproctology

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German S3 guidelines: anal abscess and fistula (second revised version)

Abstract: In this revision of the German S3 guidelines, instructions for diagnosis and treatment of anal abscess and fistula are described based on a review of current literature.

Cited by 95 publications

References 70 publications

Abszesse, Analfistel, Analfissur

Abszesse, Analfistel, Analfissur

Experimental Approval of the Efficacy of the Combined Composition Rectal Cream New Test-Samples in the Conditions of Acute Complicated Anal Fissure in Rats

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