Germacrane-Type Sesquiterpenoids from the Roots of <i>Valeriana officinalis</i> var. <i>latifolia</i>

Wang, Pengcheng; Ran, Xin; Chen, Rui; Luo, Huai‐Rong; Liu, Yuqing; Zhou, Jun; Zhao, You‐Xing

doi:10.1021/np100452a

Cited by 35 publications

(31 citation statements)

References 20 publications

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“…The result suggested that V. officinalis extract was effective in modulating LPO induced by different pro-oxidant agents and because of that V. officinalis extract, functioning as an antioxidant agent, can be beneficial for reducing insomnia complications linked to oxidative stress [73]. Fachinetto [25][26][27][28][29][30][31][32][33][34][35] ). Cultured rat hippocampal neurons were exposed to Aß (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) (25 µM) for 24-48 h, after which morphological and biochemical properties were evaluated.…”

Section: Pharmacological Activitymentioning

confidence: 99%

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Nandhini

Narayanan

Ilango

2018

Asian J Pharm Clin Res

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Valeriana is a well-known Indian traditional medicinal herb with sleep remedy. It has been used over the years to treat nervine and sedative in hysteria, epilepsy, and sedative in nervous anxiety. It has also been used as an aromatic stimulant and reported some distinctive indications, as well as its use for rheumatism, low-grade fevers, and aphrodisiac. It has been known to grow well in regions of Europe, parts of Asia and North America. This systematic review focuses on the ethnopharmacological uses of Valeriana, including recent advances on the phytochemical and pharmacological study of Valeriana officinalis. In addition, future developments and scenarios in the study of the plant have been proposed. Various literature and electronic databases such as PubMed, ScienceDirect, Springer, and Wiley were searched and data obtained. Other online academic libraries such as Google Scholar and ethnopharmacological literature were searched systematically for more information on the plant. In this paper, we have reviewed various research conducted on V. officinalis especially in areas of its ethnopharmacological use, phytochemicals, and pharmacology. This plant has been used medicinally for a minimum of 2000 years. It is used in the treatment of brain disorder and also used for the treatment of varied nervous disorders, antispasmodic, anthelmintic, diuretic, diaphoretic, and emmenagogue, and hysteria. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the plant.

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Section: Pharmacological Activitymentioning

confidence: 99%

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Nandhini

Narayanan

Ilango

2018

Asian J Pharm Clin Res

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“…Studies have shown that an extract of V. amurensis has hypnotic, antidepressive and anticonvulsive effects in the clinic, and is particularly effective as a sedative . V. amurensis contains numerous components, including monoterpenes, sesquiterpenes, iridoids, lignans, alkaloids, and flavonoids .…”

Section: Introductionmentioning

confidence: 99%

Determination and pharmacokinetic study of four lignans in rat plasma after oral administration of an extract of Valeriana amurensis by ultra‐high performance liquid chromatography with tandem mass spectrometry

Xue

Wang

et al. 2016

J of Separation Science

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A selective and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the determination and pharmacokinetic study of (+)-8-hydroxypinoresinol-4'-O-β -D-glucopyranoside, prinsepiol-4-O-β-D-glucopyranoside, (+)-pinoresinol-4,4'-di-O-β-D-glucopyranoside, and (-)-massoniresinol 3α-O-β-D-glucopyranoside in rat plasma after the oral administration of a Valeriana amurensis extract. The analytes and ethyl 4-hydroxybenzoate (internal standard) were separated on a Waters ACQUITY UPLC HSS T3 chromatographic column. The detection was performed on a triple quadrupole tandem mass spectrometer in multiple reaction monitoring mode using an electrospray ionization source operating in negative ionization mode. The linear ranges (ng/mL) of the standard curves were 0.39-154.00, 0.62-244.70, 0.50-198.60, and 0.34-134.50 for (+)-8-hydroxypinoresinol-4'-O-β-D-glucopyranoside, prinsepiol-4-O-β-D-glucopyranoside, (+)-pinoresinol-4,4'-di-O-β-D-glucopyranoside, and (-)-massoniresinol 3α-O-β-D-glucopyranoside, respectively. The inter- and intra-day precisions were less than 11.0%, the accuracies were between -5.9 and 7.7%, and the extraction recoveries of the four analytes were > 81.2% from rat plasma. The method was successfully applied to a pharmacokinetic study of the four analytes after oral administration of a Valeriana amurensis extract to rats. The developed method has the potential for pharmacokinetic analysis and to provide additional information in the clinical application of Valeriana amurensis.

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“…Finally, the bicyclogermacrene madolin A (249) showed an inhibitory activity on acetylcholinesterase 95,96 whereas partheniol (250), 97 guayulin A (251) 98 and valerianin E (252) 99 showed fungistatic activity against the growth of Aspergillus niger, allergenic activity and antidepressant activity, respectively. Volvalerenals A, B, D and E (253, 254, 257 and 258) and volvalerenic acids A-C (260, 261 and 263) were examined for acetylcholinesterase inhibitory activity, but all were inactive at 100 mM unlike madolin A (249).…”

mentioning

confidence: 99%

“…Volvalerenals A, B, D and E (253, 254, 257 and 258) and volvalerenic acids A-C (260, 261 and 263) were examined for acetylcholinesterase inhibitory activity, but all were inactive at 100 mM unlike madolin A (249). 95 The presence of an epoxide between C-1 and C-10 and the absence of functionality at C-14 might be key features for the acetylcholinesterase inhibitory activity of madolin A (249). On the other hand, valerianins A and B (264 and 265) were evaluated for their antidepressant activity based on recording the total duration of immobility of mice in a forced swim test.…”

mentioning

confidence: 99%

Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit

et al. 2015

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Germacrane-Type Sesquiterpenoids from the Roots of Valeriana officinalis var. latifolia

Cited by 35 publications

References 20 publications

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Determination and pharmacokinetic study of four lignans in rat plasma after oral administration of an extract of Valeriana amurensis by ultra‐high performance liquid chromatography with tandem mass spectrometry

Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit

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