Germ Cell Tumors of the Ovary

Baker, Patricia M.; Oliva, Esther

doi:10.1016/b978-044306920-8.50017-1

Cited by 8 publications

(23 citation statements)

References 44 publications

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“…Teratomi vode poreklo iz izmenjene jajne ćelije ili iz fuzije jajne ćelije sa sekundarnim polarnim telom ili supresije sekundarne mejotičke deobe [1,2]. Teratomi vode poreklo iz izmenjene jajne ćelije ili iz fuzije jajne ćelije sa sekundarnim polarnim telom ili supresije sekundarne mejotičke deobe [1,2].…”

Section: Uvodunclassified

“…Strumalni karcinoid jajnika je izuzetno retka neoplazma sa incidencijom manjom od 0,3% svih neoplazmi jajnika [1,2]. Radi adekvatne dijagnostike, neophodno je isključivanje metastatskih karcinoidnih depozita u područje jajnika sa drugih lokalizacija [3,6].…”

Section: Diskusijaunclassified

“…O primarnom karcinoidu jajnika po prvi put je pisao 1939. godine Stewart sa saradnicima i do danas je ostao zabeležen u udžbenicima kao izuzetno retka neoplazma [7]. U tankom crevu i apendiksu javlja se 90% karcinoida, dok je preosatalih 10% rezervisano za jajnik, testise, sakrokokcigealnu regiju, medijastinum, retroperitoneum, pod usne duplje [1,2,4,5,11,12]. Karcinoid jajnika je podeljan na četiri tipa: insularni, trabekularni, mucinozni i strumalni tip.…”

Section: Diskusijaunclassified

“…U tankom crevu i apendiksu javlja se 90% karcinoida, dok je preosatalih 10% rezervisano za jajnik, testise, sakrokokcigealnu regiju, medijastinum, retroperitoneum, pod usne duplje [1,2,4,5,11,12]. Strumalni karcinoid je po nekim autorima na drugom mestu učestalosti pojavljivanja od sva četiri tipa [1,2,8,13,14]. Strumalni karcinoid je po nekim autorima na drugom mestu učestalosti pojavljivanja od sva četiri tipa [1,2,8,13,14].…”

Section: Diskusijaunclassified

“…Karcinoidi jajnika se svrstavaju u grupu tumora niskog stepena maligniteta jer relativno retko metastaziraju, dugo rastu a u našem slučaju s obzirom da nije bilo znakova metastaza, invazije kapsule niti angiolimfatične invazije, tumor je proglašen za nosioca niskog stepena malignosti [1,2,8].…”

Section: Diskusijaunclassified

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Morphology and immunohistochemical studies of ovarian strumal carcinoid

et al. 2012

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Section: Uvodunclassified

Section: Diskusijaunclassified

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Morphology and immunohistochemical studies of ovarian strumal carcinoid

et al. 2012

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Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features

et al. 2014

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Ovarian malignant germ cell tumors (OMGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad. OMGCTs are rare, accounting for about 2.6% of all ovarian malignancies, and typically manifest in adolescence, usually with abdominal pain, a palpable mass, and elevated serum tumor marker levels, which may serve as an adjunct in the initial diagnosis, monitoring during therapy, and posttreatment surveillance. Dysgerminoma, the most common malignant germ cell tumor, usually manifests as a solid mass. Immature teratomas manifest as a solid mass with scattered foci of fat and calcifications. Yolk sac tumors usually manifest as a mixed solid and cystic mass. Capsular rupture or the bright dot sign, a result of increased vascularity and the formation of small vascular aneurysms, may be present. Embryonal carcinomas and polyembryomas rarely manifest in a pure form and are more commonly part of a mixed germ cell tumor. Some OMGCTs have characteristic features that allow a diagnosis to be confidently made, whereas others have nonspecific features, which make them difficult to diagnose. However, imaging features, the patient's age at presentation, and tumor markers may help establish a reasonable differential diagnosis. Malignant ovarian germ cell tumors spread in the same manner as epithelial ovarian neoplasms but are more likely to involve regional lymph nodes. Preoperative imaging may depict local extension, peritoneal disease, and distant metastases. Suspicious areas may be sampled during surgery. Because OMGCTs are almost always unilateral and are chemosensitive, fertility-sparing surgery is the standard of care.

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Ovarian Dysgerminoma

Michael

Wampler

Underwood

et al. 2015

Journal of Diagnostic Medical Sonography

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Dysgerminomas are rare ovarian malignancies that primarily affect young women and can occur during pregnancy. Clinically, these tumors present with lower quadrant pain and adnexal mass, and laboratory values may include elevated beta human chorionic gonadotropin (β-hCG) and lactate dehydrogenase (LDH). These symptoms, along with the sonographic findings of a large, solid lobulated adnexal mass in young women, strongly suggest an ovarian dysgerminoma in the differential diagnosis. The majority of these tumors will be diagnosed at Stage IA and will respond well to fertility-sparing surgery. This case report demonstrates both the clinical and sonographic findings unique to this rare type of ovarian malignancy.

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Germ Cell Tumors of the Ovary

Cited by 8 publications

References 44 publications

Morphology and immunohistochemical studies of ovarian strumal carcinoid

Morphology and immunohistochemical studies of ovarian strumal carcinoid

Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features

Ovarian Dysgerminoma

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