Geriatric assessment of estimated glomerular filtration rate: a cross-sectional study

Yamaguchi, Yasuko; Itabashi, Mitsuyo; Yumura, Wako; Takei, Takashi

doi:10.1007/s10157-019-01797-4

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…The eGFR cys estimated lower GFR than eGFR crea across the entire study population as well as in all subgroups. This is in line with several other studies on elderly patients [12,[14][15][16]18,20,23,24,29,[44][45][46] published after SBU's systematic review from 2012 [1]. A majority of these studies have also had mGFR as reference [12,[14][15][16]18,20,23,24,29].…”

Section: Discussionsupporting

confidence: 87%

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Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients

Dahlén¹,

Björkhem‐Bergman

2022

Life

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The aim of this study was to compare estimated glomerular filtration rate (eGFR) with creatinine (eGFRcrea) and cystatin C (eGFRcys) in geriatric and frail patients. A retrospective, cross-sectional study was performed at a geriatric clinic in Stockholm (n = 95). The revised Lund–Malmö equation was used to calculate eGFRcrea and the Caucasian-Asian-Pediatric-Adult (CAPA) equation was used for eGFRcys. The absolute mean percentage difference between eGFRcrea and eGFRcys was used as a surrogate measure for accuracy in eGFR. Other outcome measures were consistency expressed in Lin’s concordance correlation coefficient and the proportion of consistent staging of renal failure. Subgroup analyses were performed with regard to frailty (according to Clinical Frailty Scale) and age. eGFRcys estimated lower GFR than eGFRcrea across the entire study population as well as in all subgroups (p < 0.05). Difference between the estimates increased with increasing frailty (r2 = 0.15, p < 0.01), but was not significantly affected by age (r2 = 0.004, p = 0.55). In conclusion, eGFRcys was significantly lower compared to eGFRcrea in geriatric and frail patients. Moreover, frailty had greater impact than age on the accuracy of eGFR. However, this study cannot determine if any of the estimates are preferable over the other in this patient group.

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Section: Discussionsupporting

confidence: 87%

“…This was not observed between the age groups (p = 0.39). |∆eGFR mean | 37% [32,42] 23% [16,31] 42% [35,48] 38% [29,46] 37% [29,45] 34% [25,44] Proportion of |∆eGFR mean | ≥ 40% 41% [32,51] 18% [5,36] 52% [40,64] 32% [20,49] 47% [32,…”

Section: Primary Outcome Measurementioning

confidence: 99%

Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients

Dahlén¹,

Björkhem‐Bergman

2022

Life

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“…Equations based on serum cystatin C levels have proved their superiority over creatinine-based formulas in the elderly (86)(87)(88). A meta-analysis of 46 cross-sectional studies confirmed that the accuracy of cystatin C is superior to creatinine-based equations (eGFRCr) (34,78,(89)(90)(91). Alternatively, equations based on the combination of cystatin C with creatinine (CKD-EPICr+Cys) have been developed, with even better precision and accuracy compared to equations based on creatinine alone or cystatin C alone (77,92,93).…”

Section: Gfr Estimation Using Equationsmentioning

confidence: 98%

“…Several studies have addressed the discussion of the accuracy of GFR measurements in the elderly (15, [74][75][76][77][78]. Conventional approaches for determining measured GFR use the principle of renal clearance of various substances, including endogenous filtration markers (creatinine or cystatin C) or exogenous markers (such as inulin, iohexol, iothalamate, or other radiolabeled compounds).…”

Section: How To Evaluate and Interpret Gfr In The Elderlymentioning

confidence: 99%

“…In addition, these equations are based on serum creatinine, with the concerns for older patients already addressed. Both equations have been widely worldwide used, but they usually overestimate measured GFR in older patients ( 77 , 78 , 85 ), although Cockcroft-Gault adjusted for BSA yields a smaller bias ( 77 ). Of note, BSA-GFR is not a good normalization index in frail patients.…”

Section: How To Evaluate and Interpret Gfr In The Elderlymentioning

confidence: 99%

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Glomerular filtration in the aging population

et al. 2022

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In the last decades, improvements in the average life expectancy in the world population have been associated with a significant increase in the proportion of elderly people, in parallel with a higher prevalence of non-communicable diseases, such as hypertension and diabetes. As the kidney is a common target organ of a variety of diseases, an adequate evaluation of renal function in the approach of this population is of special relevance. It is also known that the kidneys undergo aging-related changes expressed by a decline in the glomerular filtration rate (GFR), reflecting the loss of kidney function, either by a natural senescence process associated with healthy aging or by the length of exposure to diseases with potential kidney damage. Accurate assessment of renal function in the older population is of particular importance to evaluate the degree of kidney function loss, enabling tailored therapeutic interventions. The present review addresses a relevant topic, which is the effects of aging on renal function. In order to do that, we analyze and discuss age-related structural and functional changes. The text also examines the different options for evaluating GFR, from the use of direct methods to the implementation of several estimating equations. Finally, this manuscript supports clinicians in the interpretation of GFR changes associated with age and the management of the older patients with decreased kidney function.

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Pentraxin-3 and adropin as inflammatory markers of early renal damage in type 2 diabetes patients

Tian

Guo

et al. 2020

Int Urol Nephrol

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Geriatric assessment of estimated glomerular filtration rate: a cross-sectional study

Cited by 6 publications

References 25 publications

Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients

Comparison of Creatinine and Cystatin C to Estimate Renal Function in Geriatric and Frail Patients

Glomerular filtration in the aging population

Pentraxin-3 and adropin as inflammatory markers of early renal damage in type 2 diabetes patients

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