Geranylated flavonoids from Dorstenia poinsettifolia

Tsopmo, Apollinaire; Tene, Mattieu; Kamnaing, Pierre; Ngnokam, David; Ayafor, J. Foyere; Sterner, Olov

doi:10.1016/s0031-9422(97)01114-x

Cited by 26 publications

(11 citation statements)

References 7 publications

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“…Phytochemical screening of the extracts showed the occurrence of flavonoids, terpenes and sterols. Flavonoids and polyphenolic compounds have been reported from many Dorstenia species (Tsopmo et al, 1998(Tsopmo et al, ,1999Dufall et al, 2003;Kansci et al, 2003;Abegaz et al, 2004;Ngameni et al, 2004). They occur as monoprenylated, diprenylated and geranylated derivatives including chalcones and other flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Omisore

Adewunmi

Iwalewa

et al. 2004

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Omisore

Adewunmi

Iwalewa

et al. 2004

Journal of Ethnopharmacology

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“…Geranylated flavonoids which have been isolated from Dorstenia mannii include 286 compound 78, and compounds 79 and 80 have been obtained from Dorstenia poinsettifolia. 287 cis-1,4-Poly-β-myrcene from the mastic resin of Pistacia lentisus appears to be the first naturally-occurring monoterpene polymer to have been isolated. 288 The polymer possesses a broad molecular weight distribution.…”

Section: 6-dimethyloctanesmentioning

confidence: 99%

Monoterpenoids (mid-1997 to mid-1999)

Grayson

2000

Nat. Prod. Rep.

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In situ RNA hybridization and immunocytochemistry were used to establish the cellular distribution of monoterpenoid indole alkaloid biosynthesis in Madagascar periwinkle (Catharanthus roseus). Tryptophan decarboxylase (TDC) and strictosidine synthase (STR1), which are involved in the biosynthesis of the central intermediate strictosidine, and desacetoxyvindoline 4-hydroxylase (D4H) and deacetylvindoline 4-O-acetyltransferase (DAT), which are involved in the terminal steps of vindoline biosynthesis, were localized. tdc and str1 mRNAs were present in the epidermis of stems, leaves, and flower buds, whereas they appeared in most protoderm and cortical cells around the apical meristem of root tips. In marked contrast, d4h and dat mRNAs were associated with the laticifer and idioblast cells of leaves, stems, and flower buds. Immunocytochemical localization for TDC, D4H, and DAT proteins confirmed the differential localiza-tion of early and late stages of vindoline biosynthesis. Therefore, we concluded that the elaboration of the major leaf al-kaloids involves the participation of at least two cell types and requires the intercellular translocation of a pathway intermediate. A basipetal gradient of expression in maturing leaves also was shown for all four genes by in situ RNA hy-bridization studies and by complementary studies with dissected leaves, suggesting that expression of the vindoline pathway occurs transiently during early leaf development. These results partially explain why attempts to produce vin-doline by cell culture technology have failed. INTRODUCTION The organs forming the plant body consist of several different cell types that are organized in relation to each other and that confer specific functions to the resulting organ. Each cell type emerges from an undifferentiated meristem according to a sophisticated and partially understood developmental program (Sylvester et al., 1996; von Arnim and Deng, 1996). The commitment to differentiate into specialized structures involves the perception by cells in the meristem of a complex array of signals, which communicate cellular age, position in relation to other cells, and hormonal balance. Environmental factors, such as light and temperature, also play a critical role in modulating these signals throughout the process of organogenesis (Bernier, 1988; Dale, 1988; Sylvester et al., 1996). In addition to morphogenesis, developmental processes result in biochemical specialization of cells for the biosyn-thesis and/or accumulation of secondary metabolites, such as phenylpropanoids (Ibrahim et al.

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“…angusta Engl. (Moraceae) [ 68 ], Escobar et al condensed quercetin with citral under microwave irradiation to obtain the benzopyran intermediate 66 which could be possibly converted into the natural target by C-6 prenylation [ 69 ]. Unfortunately, this operation failed to provide C - and/or O -prenylated derivatives and gave degradation products of 66 depending on the reaction conditions.…”

Section: Synthesis and Anticancer-related Activities Of Quercetin mentioning

confidence: 99%

Research Progress in the Modification of Quercetin Leading to Anticancer Agents

et al. 2017

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The flavonoid quercetin (3,3′,4′,5,7-pentahydroxyflavone) is widely distributed in plants, foods, and beverages. This polyphenol compound exhibits varied biological actions such as antioxidant, radical-scavenging, anti-inflammatory, antibacterial, antiviral, gastroprotective, immune-modulator, and finds also application in the treatment of obesity, cardiovascular diseases and diabetes. Besides, quercetin can prevent neurological disorders and exerts protection against mitochondrial damages. Various in vitro studies have assessed the anticancer effects of quercetin, although there are no conclusive data regarding its mode of action. However, low bioavailability, poor aqueous solubility as well as rapid body clearance, fast metabolism and enzymatic degradation hamper the use of quercetin as therapeutic agent, so intense research efforts have been focused on the modification of the quercetin scaffold to obtain analogs with potentially improved properties for clinical applications. This review gives an overview of the developments in the synthesis and anticancer-related activities of quercetin derivatives reported from 2012 to 2016.

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Geranylated flavonoids from Dorstenia poinsettifolia

Cited by 26 publications

References 7 publications

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Monoterpenoids (mid-1997 to mid-1999)

Research Progress in the Modification of Quercetin Leading to Anticancer Agents

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