Geospatial analysis of tegumentary leishmaniasis in Rio de Janeiro state, Brazil from 2000 to 2015: Species typing and flow of travelers and migrants with leishmaniasis

Miranda, Luciana de Freitas Campos; Pacheco, Raquel da Silva; Pimentel, Maria Inês Fernandes; Salgueiro, Mariza de Matos; Fagundes, Aline; Mello, Cintia Xavier de; Barros, Juliana Helena da Silva; Valete‐Rosalino, Cláudia Maria; Madeira, Maria de Fátima; Xavier, Samanta Cristina das Chagas; Schubach, Armando de Oliveira

doi:10.1371/journal.pntd.0007748

Cited by 6 publications

(3 citation statements)

References 45 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The World Health Organization recognizes multilocus enzyme electrophoresis as the gold standard for parasite typing, based on parasite culture separations. This technique has evaluated nearly all currently known Leishmania species. , However, it is a laborious and time-consuming method that is used in only a few laboratories worldwide. For accurate identification in complex living structures, high-resolution MS with high mass precision is often necessary .…”

Section: Identification and Classification Of Parasitesmentioning

confidence: 99%

See 1 more Smart Citation

Mass Spectrometry Imaging: An Emerging Technology in Medical Parasitology

Yu,

Zhan,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

Section: Identification and Classification Of Parasitesmentioning

confidence: 99%

“…This technique has evaluated nearly all currently known Leishmania species. 38,39 However, it is a laborious and time-consuming method that is used in only a few laboratories worldwide. For accurate identification in complex living structures, high-resolution MS with high mass precision is often necessary.…”

mentioning

confidence: 99%

Mass Spectrometry Imaging: An Emerging Technology in Medical Parasitology

Yu,

Zhan,

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

“…L. (V.) braziliensis and its variants constitute a genetically related group, found both in different natural biomes and those modified by human action (5,7) transmitted by various sandflies of the genus Lutzomyia, with rodents and marsupials considered reservoirs. Human infection by L. (V.) braziliensis is characterized by chronicity and latency, producing single or multiple ulcerated skin lesions that can self heal but with the possibility of local reactivation and late destructive metastatic involvement of the naso-oro-pharyngeal mucosa (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Anthropogenic Dispersal of Leishmania (Viannia) braziliensis in the Americas: A Plausible Hypothesis

Marzochi

Fagundes

et al. 2021

Front. Trop. Dis

Self Cite

View full text Add to dashboard Cite

There are several gaps in our knowledge on the origin and spread of Leishmania (Viannia) braziliensis, an etiological agent of cutaneous and mucocutaneous or American tegumentary leishmaniasis, to different biomes, hosts, and vectors, with important epidemiological implications, including the possible existence of an anthroponotic component. Historical, biological, and epidemiological evidence suggests that Leishmania (V.) braziliensis and its variants were preexistent in Amazonia with great genetic variability, where they dispersed with less variability to other regions (clonal expansion). During pre-Columbian times the parasite may have been transported by migrating humans and probably also their dogs, from western Amazonia to the high inter-Andean valleys and from there to other regions of South America. The same thing could have happened later, in the same way, when it spread to non-Amazonian regions of Brazil and other countries of South and Central America, between the late 19th and early 20th centuries, during the so-called Rubber Boom and construction of the Madeira-Mamoré Railway in the Brazilian Amazon, by migrant workers who later returned to their places of origin, transporting the agent. The parasite’s dispersal in genetic correlated clusters, involving unexpectedly distinct ecosystems in Brazil (Amazonian, Cerrado, Caatinga and Atlantic Forest biomes), has continued until the present through human displacement. The infection of certain species of domestic, synanthropic and even wild animals, could be secondary to anthropogenic introduction of L. (V.) braziliensis in new environments. We admit the same phenomena happening in the probable transference of Leishmania infantum (visceral leishmaniasis), and of Yersinia pestis (plague) from the Old world to the New world, generating domestic and wild enzotic cycles from these agents. These assumptions associated with human infections, chronicity and parasite persistence with possibility of recovery of Leishmania in peripheral blood, skin and scars of cured or asymptomatic patients, (that may provide an alternative blood meal), along with the sand flies’ adaptation to the peri-domicile and the high susceptibility of domestic dogs, horses, mules and cats to the parasite, can reinforce the evidence of anthropogenic spread of L. (V.) braziliensis.

show abstract