In this study, an analysis of coastal vulnerability and flood risk due to sea-level rise was conducted in the southern margin of the Ría of Arosa, Pontevedra (Spain), which is an area of urban impact and tourist activity. The vulnerability index was calculated using the following parametric maps: lithology, geomorphology, slope, elevation, distance, coastline change, significant wave height, sea level, and extreme tidal range. This vulnerability index was validated through the results obtained from the flood risk analysis, developed for different temporal and extreme scenarios (Xa—present, Xb—100 years, Xc—500 years, Xd—1000 years, Xe—storm, and Xf—tsunami). These analyses were performed using Geographic Information System and remote sensing techniques, spatial analysis, interpolation processes, and geostatistical analysis. The results of the analysis show the vulnerable areas and areas at high risk of coastal flooding, with the urbanized area exposed to a risk of 7.45 km2. Thus, this study contributes to designing appropriate management for the coastline of the southern margin of the Ría of Arosa in the event of a flood.