Geometry-based pressure drop prediction in mildly diseased human coronary arteries

Schrauwen, Jelle T. C.; Wentzel, Jolanda J.; Steen, Antonius F.W. van der; Gijsen, Frank

doi:10.1016/j.jbiomech.2014.03.028

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…A previous study showed that, for instance, at Re = 175 this increase was 14.8 ± 10.0%. 22 A first possibility is to choose the same approach as that shown here, but with a curvilinear formulation rather than a cylindrical. While this leads to a mathematically more extensive formulation, it might still be possible to evaluate it.…”

Section: Discussionmentioning

confidence: 99%

“…A second, more pragmatic, approach would be to find a geometric measure for the curvature and relate this to the additional pressuredrop the curvature causes. 22 Apart from including 3D curvature, another limitation for accurate WSS assessment is that the microcirculation has to be taken into account, since this is a key determinant for the flow distribution. However, it cannot be visualized directly with the available imaging techniques.…”

Section: Discussionmentioning

confidence: 99%

“…An inlet of five times the inlet radius was added to the reconstruction (VMTK, www.vmtk.org). 22 The geometries were meshed with GAMBIT (AN-SYS, Inc., Canonsburg, PA, USA). Mesh independency studies were conducted, resulting in a surface mesh of triangular elements with an element size of 1.25 9 10 22 mm and a volume mesh with approximately 10 6 tetrahedral elements.…”

Section: Geometrical Reconstruction and Cfdmentioning

confidence: 99%

“…7 Previous work from our group extended those models to incorporate more patient-specific geometrical features. 22 On average these models performed well, but large deviations can occur per individual vessel.…”

Section: Introductionmentioning

confidence: 96%

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Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries

et al. 2014

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Abstract-Atherosclerotic disease progression in coronary arteries is influenced by wall shear stress. To compute patient-specific wall shear stress, computational fluid dynamics (CFD) is required. In this study we propose a method for computing the pressure-drop in regions proximal and distal to a plaque, which can serve as a boundary condition in CFD. As a first step towards exploring the proposed method we investigated ten straightened coronary arteries. First, the flow fields were calculated with CFD and velocity profiles were fitted on the results. Second, the Navier-Stokes equation was simplified and solved with the found velocity profiles to obtain a pressure-drop estimate (Dp (1) ). Next, Dp (1) was compared to the pressure-drop from CFD (Dp CFD ) as a validation step. Finally, the velocity profiles, and thus the pressure-drop were predicted based on geometry and flow, resulting in Dp geom . We found that Dp (1) adequately estimated Dp CFD with velocity profiles that have one free parameter b. This b was successfully related to geometry and flow, resulting in an excellent agreement between Dp CFD and Dp geom : 3.9 ± 4.9% difference at Re = 150. We showed that this method can quickly and accurately predict pressure-drop on the basis of geometry and flow in straightened coronary arteries that are mildly diseased.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Geometrical Reconstruction and Cfdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries

et al. 2014

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“…Ultimately, for this technology to be incorporated into routine clinical practice, medical image data processing and CFD simulations need to be automated [69] and simplified [81] such that patient-specific vFFR values can be obtained in an actionable time-frame. An automated process resulting in fast and highly accurate online vFFR would provide interventional cardiologists the optimum strategies for treatment of CAD, benefiting more patients and potentially cutting healthcare costs.…”

Section: Future Of Virtual Fractional Flow Reservementioning

confidence: 99%

Advances in three-dimensional coronary imaging and computational fluid dynamics

Poon

Hayat²,

Thondapu³

et al. 2015

Coronary Artery Disease

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Percutaneous coronary intervention (PCI) has shown a high success rate in the treatment of coronary artery disease. The decision to perform PCI often relies on the cardiologist's visual interpretation of coronary lesions during angiography. This has inherent limitations, particularly due to the low resolution and two-dimensional nature of angiography. State-of-the-art modalities such as three-dimensional quantitative coronary angiography, optical coherence tomography and invasive fractional flow reserve (FFR) may improve clinicians' understanding of both the anatomical and physiological importance of coronary lesions. While invasive FFR is the gold standard technique for assessment of the haemodynamic significance of coronary lesions, recent studies have explored a surrogate for FFR derived solely from three-dimensional reconstruction of the invasive angiogram, and therefore eliminating need for a pressure wire. Utilizing advanced computational fluid dynamics research, this virtual fractional flow reserve (vFFR) has demonstrated reasonable correlation with invasive measurements and remains an intense area of ongoing study. However, at present, several limitations and computational fluid dynamic assumptions may preclude vFFR from widespread clinical use. This review demonstrates the tight integration of advanced three-dimensional imaging techniques and vFFR in assessing coronary artery disease, reviews the advantages and disadvantages of such techniques and attempts to provide a glimpse of how such advances may benefit future clinical decision-making during PCI.

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Coronary arterial geometry: A comprehensive comparison of two imaging modalities

Blanco¹,

Bulant

Bezerra

et al. 2021

Numer Methods Biomed Eng

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The characterization of vascular geometry is a fundamental step towards the correct interpretation of coronary artery disease. In this work, we report a comprehensive comparison of the geometry featured by coronary vessels as obtained from coronary computed tomography angiography (CCTA) and the combination of intravascular ultrasound (IVUS) with bi‐plane angiography (AX) modalities. We analyzed 34 vessels from 28 patients with coronary disease, which were deferred to CCTA and IVUS procedures. We discuss agreement and discrepancies between several geometric indexes extracted from vascular geometries. Such an analysis allows us to understand to which extent the coronary vascular geometry can be reliable in the interpretation of geometric risk factors, and as a surrogate to characterize coronary artery disease.

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Geometry-based pressure drop prediction in mildly diseased human coronary arteries

Cited by 21 publications

References 35 publications

Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries

Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries

Advances in three-dimensional coronary imaging and computational fluid dynamics

Coronary arterial geometry: A comprehensive comparison of two imaging modalities

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