Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension

Fridez, Pierre; Zulliger, Martin A.; Bobard, F; Montorzi, Gabriela; Miyazaki, Hiroshi; Hayashi, Kozaburo; Stergiopulos, Nikolaos

doi:10.1016/s0021-9290(02)00445-1

Cited by 69 publications

(73 citation statements)

References 20 publications

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“…Langille et al 1989); and they show that inner radius remains constant while wall thickness increases and thus circumferential wall stress normalizes within a few weeks in cases of increased pressure (cf. Matsumoto & Hayashi 1994;Fridez et al 2002Fridez et al , 2003Hu et al 2007b). Indeed, by yielding reasonable time courses, in days to weeks or months, the current predictions suggest that complete adaptations may take longer than studied in some animal models.…”

Section: Discussionmentioning

confidence: 58%

Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure

Valentín

Cardamone

Baek

et al. 2008

J. R. Soc. Interface.

152

230

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Arteries exhibit a remarkable ability to adapt to sustained alterations in biomechanical loading, probably via mechanisms that are similarly involved in many arterial pathologies and responses to treatment. Of particular note, diverse data suggest that cell and matrix turnover within vasoaltered states enables arteries to adapt to sustained changes in blood flow and pressure. The goal herein is to show explicitly how altered smooth muscle contractility and matrix growth and remodelling work together to adapt the geometry, structure, stiffness and function of a representative basilar artery. Towards this end, we employ a continuum theory of constrained mixtures to model evolving changes in the wall, which depend on both wall shear stress-induced changes in vasoactive molecules (which alter smooth muscle proliferation and synthesis of matrix) and intramural stress-induced changes in growth factors (which alter cell and matrix turnover). Simulations show, for example, that such considerations help explain the different rates of experimentally observed adaptations to increased versus decreased flows as well as differences in rates of change in response to increased flows or pressures.

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Section: Discussionmentioning

confidence: 58%

Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure

Valentín

Cardamone

Baek

et al. 2008

J. R. Soc. Interface.

152

230

View full text Add to dashboard Cite

show abstract

“…Such increase in diameter may occur to restore the wall shear stress against the increase in the blood flow caused by the shunt (5), (6) . The changes in the mechanical properties of arteries exposed to hypertension have been studied rather extensively (1) - (3), (7) - (9) . Other than wall thickening to maintain the in vivo stress at a constant level, decrease in both the inner diameter and the incremental elastic modulus over the normotensive pressure range, increase in the opening angle and in the longitudinal length of unloaded segments, etc.…”

Section: Introductionmentioning

confidence: 99%

Flow-Induced Changes in Dimensions and Mechanical Properties of Rabbit Common Carotid Arteries

Matsumotο

Okumura

Shirono

et al. 2005

JSME Int. J., Ser. C

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Flow-induced changes in dimensions and mechanical properties of blood vessel wall were studied in the rabbit left common carotid arteries connected directly to the left external jugular vein via an arteriovenous fistula (AVF) to increase its blood flow by >10-fold for 4 weeks. Contralateral artery was used as control. We found significant increase not only in diameter, but also in thickness and length of unloaded artery exposed to increased flow, indicating the increase in wall volume. The increase in diameter and thickness but not in longitudinal length correlated significantly with the volumetric increase of the wall. Pressure-imposed test showed that the wall became less distensible in response to flow increase. Fluid shear stress estimated for physiological condition was significantly higher in AVF side than control, indicating that 10-fold increase in flow was not compensated in 4 weeks. Circumferential strain in a physiological pressure range was significantly lower in AVF side, while hoop stress was similar in both sides. These results may indicate that circumferential stress but not strain is maintained constant, and longitudinal change is not regulated in flow-imposed arteries.

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“…However, it is well established that the development of hypertension is associated with an increase in ECM proteins, including elastin, in the arterial wall. This, with few exceptions [30] has been reported in rat with genetic [31], and experimental hypertension [14,[32][33][34].…”

Section: Discussionmentioning

confidence: 77%

An increase of elastic tissue fibers in blood vessel walls of placental stem villi and differences in the thickness of blood vessel walls in third trimester pre-eclampsia pregnancies

et al. 2010

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AbstractThis study has goals of examining whether pre-eclampsia may lead to an increase of elastic tissue fibers in blood vessel walls of placental stem villi or whether there are differences in the thickness of blood vessel walls within these villi when compared to normotensive pregnant women. Non-infarcted placental tissue samples from 28 participants with uncomplicated pregnancies and 26 patients with pre-eclampsia were obtained. After routine histological procedures, the sections were processed either for conventional Verhoeff staining for the demonstration of elastic fiber system. Paraffine sections from placenta biopsies prepared for light microscopic examination were gathered. In uncomplicated pregnancies, terminal villi blood vessels were observed with no stained elastic tissue fibers in most areas. In the pre-eclampsia pregnancy of human placenta, the elastic fibers significiantly increased in terminal villi blood vessel walls which were dark in color, using Verhoeff’s tissue stain, when comparing with the uncomplicated pregnancy group. Our results indicate that an increase of elastic tissue fibers in blood vessels of placental stem villus and terminal villi, and also an increase of wall thickness during pre-eclampsia.

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Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension

Cited by 69 publications

References 20 publications

Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure

Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure

Flow-Induced Changes in Dimensions and Mechanical Properties of Rabbit Common Carotid Arteries

An increase of elastic tissue fibers in blood vessel walls of placental stem villi and differences in the thickness of blood vessel walls in third trimester pre-eclampsia pregnancies

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