Geometric, elastic and contractile-relaxation changes in coronary arterioles induced by Vitamin D deficiency in normal and hyperandrogenic female rats

Hadjadj, Leila; Monori-Kiss, Anna; Horváth, Eszter; Heinzlmann, Andrea; Magyar, Attila; Sziva, Réka Eszter; Miklós, Zsuzsanna; Pál, Éva; Gál, János; Szabó, István; Benyó, Zoltán; Nádasy, György L.; Várbı́ró, Szabolcs

doi:10.1016/j.mvr.2018.11.011

Cited by 8 publications

(14 citation statements)

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“…Unchanged α-SMA expression and smooth muscle cell nucleus count found in this study might indicate that the contractile part of the vessels was not affected within 8 weeks. Lowered wall stress and reduced elastic modulus of arteriole segments were shown in the coronary artery from vitamin-D-deficient female rats [ 23 ]. Cerebral artery from vitamin-D-deficient male rats had attenuated wall stress [ 19 ].…”

Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

“…On the other hand, in case of vitamin-D-dependency, the organ or tissue cannot adapt by receptor-upregulation to the concentration changes, so it will be sensitive and vulnerable to vitamin D deficiency. According to our previous results from animal experiments, small vessels from the heart and brain are vitamin-D-dependent tissues, because in extreme vitamin-D-deficient milieu, they go through major changes [ 18 , 19 , 23 , 37 , 42 ], but these alterations are depending on which region the vessels are originated from. Both vitamin D deficiency and toxicity can induce smaller carotid artery diameter and larger wall thickness in male Wistar rat models within 4 weeks [ 43 ].…”

Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

“…Resistance vessels from spontaneous (genetically) hypertensive rats (SHR) have smaller lumen diameter and thicker wall and media thickness [22]. Analogous trophic vascular consequences, such as reduced lumen with increased wall thickness, were found in female rats with similar vitamin-D-deficient background [23], indicating that the pre-hypertensive adaptation in small intramural coronary arteries is independent of gender. These alterations can be considered as pre-hypertensive adaptation due to unchanged blood pressure.…”

Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

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Vitamin D Deficiency Induces Elevated Oxidative and Biomechanical Damage in Coronary Arterioles in Male Rats

et al. 2020

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Background: Several reports prove interconnection between vitamin D (VD) deficiency and increased cardiovascular risk. Our aim was to investigate the effects of VD status on biomechanical and oxidative–nitrative (O–N) stress parameters of coronary arterioles in rats. Methods: 4-week-old male Wistar rats were divided into a control group (11 animals) with optimal VD supply (300 IU/kgbw/day) and a VD-deficient group (11 animals, <5 IU/kg/day). After 8 weeks, coronary arteriole segments were prepared. Geometrical, elastic, and biomechanical characteristics were measured by in vitro arteriography. O–N stress markers were investigated by immunohistochemistry. Results: Inner radius decreased; wall thickness and wall-thickness/lumen diameter ratio increased; tangential wall stress and elastic modulus were reduced in VD-deficient group. No difference could be found in wall-cross-sectional area, intima-media area %. While the elastic elements of the vessel wall decreased, the α-smooth muscle actin (α-SMA) immunostaining intensity showed no changes. Significant elevation was found in the lipid peroxidation marker of 4-hidroxy-2-nonenal (HNE), while other O–N stress markers staining intensity (poly(ADP)ribose, 3-nitrotyrosine) did not change. Conclusions: Inward eutrophic remodeling has developed. The potential background of these impairments may involve the initial change in oxidative damage markers (HNE). These mechanisms can contribute to the increased incidence of the cardiovascular diseases in VD deficiency.

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Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

Section: Discussion Limitations and Strengthsmentioning

confidence: 99%

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Vitamin D Deficiency Induces Elevated Oxidative and Biomechanical Damage in Coronary Arterioles in Male Rats

et al. 2020

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“…Figure 2A Figure 2B demonstrates the design space for the flexural stiffness  of tubular structures with thickness varying from 0.5 to 2 m and Young's modulus varying from 1 to 200 GPa. For in vivo hSMPA, thicknesses of 10 to 30 m and Young's moduli of 15 to 500 kPa have been reported in the literature (40)(41)(42)(43). The inserted plane in Fig.…”

Section: Mechanical Considerations For the Tubular Constructsmentioning

confidence: 90%

Biomimetic human small muscular pulmonary arteries

et al. 2020

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Changes in structure and function of small muscular arteries play a major role in the pathophysiology of pulmonary hypertension, a burgeoning public health challenge. Improved anatomically mimetic in vitro models of these microvessels are urgently needed because nonhuman vessels and previous models do not accurately recapitulate the microenvironment and architecture of the human microvascular wall. Here, we describe parallel biofabrication of photopatterned self-rolled biomimetic pulmonary arterial microvessels of tunable size and infrastructure. These microvessels feature anatomically accurate layering and patterning of aligned human smooth muscle cells, extracellular matrix, and endothelial cells and exhibit notable increases in endothelial longevity and nitric oxide production. Computational image processing yielded high-resolution 3D perspectives of cells and proteins. Our studies provide a new paradigm for engineering multicellular tissues with precise 3D spatial positioning of multiple constituents in planar moieties, providing a biomimetic platform for investigation of microvascular pathobiology in human disease.

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“…Moreover, through direct interaction with nuclear factor kappa beta (NFkB) [25], vitamin D deficiency triggered inflammation both in epicardial fat [25] and in vascular wall, further augmenting the inflammatory response that has been deemed as detrimental for the progression of coronary artery disease and the fragility of the atheroma [26]. At the level of the arterioles, vitamin D concentrations affect the contractility of the muscular layer, and its deficiency increases vascular rigidity [27]. Mice that were fed an atherogenic diet that was deficient in vitamin D demonstrated increased vascular calcification [28].…”

Section: Links Between Vitamin D Status and Cardiovascular Diseasementioning

confidence: 99%

The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease

Paschou

Kosmopoulos²,

Nikas³

et al. 2019

Nutrients

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The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD.

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Geometric, elastic and contractile-relaxation changes in coronary arterioles induced by Vitamin D deficiency in normal and hyperandrogenic female rats

Cited by 8 publications

References 30 publications

Vitamin D Deficiency Induces Elevated Oxidative and Biomechanical Damage in Coronary Arterioles in Male Rats

Vitamin D Deficiency Induces Elevated Oxidative and Biomechanical Damage in Coronary Arterioles in Male Rats

Biomimetic human small muscular pulmonary arteries

The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease

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