A series of analyses, including variable-density flow simulations, was used to examine groundwater flow in the vicinity of the Waste Isolation Pilot Plant (WIPP) in the context of the regional flow system. WIPP is an underground repository mined from a thick bedded-salt unit to provide a facility for the disposal of radioactive waste. WIPP is located in southeastern New Mexico. The analyses primarily examined the Culebra Dolomite Member of the Rustler Formation, which is a potential pathway for the transport of radionuclides to the biosphere in the event of a breach of the WIPP repository. An analysis of the relative magnitude of pressure-related and density-related flow-driving forces indicates that density-related forces are not significant at the WIPP site and to the west but are significant in areas to the north, northeast, and south of the site. The area to the south is important because it lies along potential transport pathways from the site. In this area, groundwater flow simulations based on equivalent-fresh water head produce very misleading information on predicted flow directions and velocity magnitudes. A regional-scale, variable-density model of groundwater flow in the Culebra Dolomite Member was developed in which a baseline, approximate steady-state simulation was calibrated to the distribution of equivalent-fresh water heads. The flow field from the baseline simulation, along with long-term brine transport patterns, indicates that flow velocities are relatively fast west of the site and extremely slow east and northeast of the site. In the transition zone between these two extremes, which includes the WIPP site, velocities are highly variable.