Geography influences microsatellite polymorphism diversity in Amerindians

Kohlrausch, Fabiana B.; Callegari-Jacques, Sídia M.; Tsuneto, Luiza Tamie; Petzl-Erler, María Luiza; Hill, Kim; Hurtado, Ana; Salzano, Francisco M.; Hutz, Mara H.

doi:10.1002/ajpa.20042

Cited by 33 publications

(28 citation statements)

References 31 publications

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“…Just as there were differences in susceptibility genes between close villages in the Sudan and even between populations from different founders within villages, the different outcome of our study versus the other genome scan of multiplex VL families in Brazil could reflect underlying genetic heterogeneity of the population and the VL trait. Indeed, Brazilians are a genetically admixed population, and regional differences have already been documented between residents of different Brazilian states [28,29].…”

Section: Discussionmentioning

confidence: 98%

Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Jerônimo

Duggal

Ettinger³

et al. 2007

J INFECT DIS

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The protozoan Leishmania chagasi can cause disseminated, fatal visceral leishmaniasis (VL) or asymptomatic infection in humans. We hypothesized that host genetic factors contribute to this variable response to infection. A family study was performed in neighborhoods of endemicity for L. chagasi near Natal in northeastern Brazil. Study subjects were assessed for the presence of VL or asymptomatic infection, which was defined by a positive delayed-type hypersensitivity (DTH) skin test response to Leishmania antigen without disease symptoms. A genomewide panel of 385 autosomal microsatellite markers in 1254 subjects from 191 families was analyzed to identify regions of linkage. Regions with potential linkage to the DTH response on chromosomes 15 and 19, as well as a novel region on chromosome 9 with potential linkage to VL, were identified. Understanding the genetic factors that determine whether an individual will develop symptomatic or asymptomatic infection with L. chagasi may identify proteins essential for immune protection against this parasitic disease and reveal strategies for immunotherapy or prevention.

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Section: Discussionmentioning

confidence: 98%

Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Jerônimo

Duggal

Ettinger³

et al. 2007

J INFECT DIS

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“…We used pooled allele frequencies from the following populations to represent African, Amerindian, and European parental populations: seven African countries (Angola, Cabinda, Cabo Verde, Guinea-Bissau, Mozambique, Nigeria, and Sã o Tomé); seven Amerindian populations (Caingang, Guarani, Gaviã o, Suruí, Wai Wai, Xavante, and Zoró); and Portugal (http://www. uni-duesseldorf.de/WWW/MedFak/Serology/dna.html; Hutz et al, 2002;Beleza et al, 2004;Kohlrausch et al, 2005). The origins and sizes of these parental populations are described in the supporting information.…”

Section: Dna and Statistical Analysesmentioning

confidence: 99%

Brief communication: Admixture analysis with forensic microsatellites in Minas Gerais, Brazil: The ongoing evolution of the capital and of an African‐derived community

Scliar

Vaintraub²,

Vaintraub³

et al. 2009

American J Phys Anthropol

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We report the estimated allele frequencies for 13 and 14 microsatellite loci in two populations of Minas Gerais, Brazil as follows: Belo Horizonte (the capital) and Marinhos (an African-derived community). Analysis of the African, Amerindian, and European genetic contributions to both populations, together with historical information, revealed distinct differences between the two populations. Estimates for Belo Horizonte revealed a higher-European (66%) than African (32%) contribution, and a minimal Amerindian contribution. These results are consistent with the peopling of the city mainly by people from the Minas Gerais hinterland, a people highly admixed but with more European ancestry. Estimates for Marinhos confirmed the high-African component of the population. However, a temporal analysis of two datasets-CURRENT (representing the population living in Marinhos today) and ORIGINAL (representing families, who have lived in Marinhos since the onset of the 20th century),-identified a diminishing of the population's African ancestry from 92% in the ORIGINAL group to 67% in the CURRENT group. This change is here interpreted as a consequence of the growing migration into the village of people with more European ancestry and subsequent admixture with the local population.

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“…In addition, the results in north-eastern Eurasians and all American samples denote that this haplotype had high frequencies in the ancestors of American populations. Its frequencies in the South American Karitiana and Surui may have been affected by the historical small effective sizes of these populations (Kidd et al 1991;Kohlrausch et al 2005).…”

Section: Discussionmentioning

confidence: 98%

A human derived SSADH coding variant is replacing the ancestral allele shared with primates

Leone

Blasi

Palmerio

et al. 2006

Annals of Human Biology

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Geography influences microsatellite polymorphism diversity in Amerindians

Cited by 33 publications

References 31 publications

Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Brief communication: Admixture analysis with forensic microsatellites in Minas Gerais, Brazil: The ongoing evolution of the capital and of an African‐derived community

A human derived SSADH coding variant is replacing the ancestral allele shared with primates

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