Genetic Predisposition to Self‐Curing Infection with the Protozoan<i>Leishmania chagasi:</i>A Genomewide Scan

Jerônimo, Selma M. B.; Duggal, Priya; Ettinger, Nicholas; Nascimento, Eliana T.; Monteiro, Gloria Regina de Góis; Cabral, Angela P.; Pontes, Nubia N.; Lacerda, Hênio Godeiro; Queiroz, Paula V. S.; Gomes, Camila de Carvalho; Pearson, Richard D.; Blackwell, Jenefer M.; Beaty, Terri H.; Wilson, Mary E.

doi:10.1086/521682

Cited by 51 publications

(76 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, other studies have shown differences in the level of MBL between genders in those infected with VL. After puberty, teenagers and adult males are among the most affected by VL owing to hormonal fluctuations that may influence susceptibility to the disease (Jeronimo et al, 2007;Nylén et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Silva¹,

Júnior²,

Monteiro³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Visceral leishmaniasis (VL) is one of the seven priority endemic diseases in the world. The clinical outcome of many infections is not only dependent on the pathogenic organism, but also on the genetic variability of the host susceptibility to infection. Mannose-binding lectin (MBL) is a Levels of mannose-binding lectin in leishmaniasis patients 19095©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 19094-19101 (2015) protein that plays an important role in the innate immune system. The aim of this study was to compare the serum levels of MBL between healthy controls and carriers of VL. The VL cases were recruited randomly from the main hospitals and referral outpatient clinics for VL in São Luís, and from home visits. Determination of MBL protein levels was performed by enzyme-linked immunosorbent assay. Of the 161 patients with VL and the 161 healthy controls, 60.9 and 67.1% had high levels of MBL, respectively. There was no significant difference in MBL levels between cases and controls. Low socioeconomic status and living conditions are conducive to the occurrence of VL. Owing to the small number of existing studies, it is extremely important to conduct further studies on MBL levels and susceptibility to VL, especially in regions where the disease is endemic, such as Maranhão, Brazil.

show abstract

Section: Discussionmentioning

confidence: 99%

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Silva¹,

Júnior²,

Monteiro³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Visceral leishmaniasis (VL), also known as kala-azar, is caused by the protozoa of the Leishmania donovani complex 3 . Although the risk factors for this disease are not fully understood, it is known that genetic factors, malnutrition and the presence of infected animals in the environment are major contributors to the high maintenance rate of this disease [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

“…Although the factors that lead to the development of the disease are still unclear, the complex interactions between the parasite, the immune response and the nutritional status may infl uence the host's response to Leishmania infection 4,[13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Gatto

Abreu

Tasca

et al. 2013

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Revista da Sociedade Brasileira de Medicina Tropical 46(6):735-740, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0198-2013 ABSTRACT Introduction: Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods: Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results: BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions: Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. INTRODUCTION

show abstract

“…An important factor is the diversity of the species that cause disease, which includes clonal differences within the same species that lead to clinical variants (1)(2)(3). Another determinant is the absolute parasite numbers that infect the host, which can influence the infection outcome in combination with the immunological and genetic characteristics of the host (4,5).…”

mentioning

confidence: 99%

Comparative Evaluation of Lesion Development, Tissue Damage, and Cytokine Expression in Golden Hamsters (Mesocricetus auratus) Infected by Inocula with Different Leishmania (Viannia) braziliensis Concentrations

et al. 2014

View full text Add to dashboard Cite

The golden hamster (Mesocricetus auratus) is a susceptible model to Leishmania (Viannia) spp.; however, available studies employ different infection protocols, which account for clinical and pathological presentation differences. Herein, L. (V.) braziliensis preparations were standardized to contain 10 4 , 10 5 , or 10 6 parasites to determine an optimal inoculum that ensured cutaneous lesions without causing a disseminated infection in hamsters. Lesion development was followed for 105 days by size measurements, and skin, draining lymph node, spleen, and sera were investigated to check parasite load, spleen visceralization, cytokine expression, histopathological changes, and anti-Leishmania IgG levels. The lesion emergence time was inversely proportional to the parasite concentration in the inocula. Animals infected by 10 4 parasites presented nodular lesions, while those infected with 10 6 parasites often exhibited ulcerated lesions. The differences in the final lesion sizes were observed between 10 4 and 10 5 inocula or 10 4 and 10 6 inocula. High IFNG expression, anti-Leishmania IgG levels, and parasite load occurred independently of the inoculum used. A mild inflammatory skin involvement was observed in animals infected with 10 4 parasites, while extensive tissue damage and parasite spleen visceralization occurred with 10 5 and 10 6 parasites. These results indicate that inocula with different concentrations of parasites generate differences in the time of lesion emergence, clinical presentation, and systemic commitment, despite high and similar IFNG expression and parasite load. This suggests that a modulation in the immune response to different parasite numbers occurs in an early phase of the infection, which could dictate the establishment and magnitude of the chronic phase of the disease.

show abstract

Genetic Predisposition to Self‐Curing Infection with the ProtozoanLeishmania chagasi:A Genomewide Scan

Cited by 51 publications

References 28 publications

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Comparative Evaluation of Lesion Development, Tissue Damage, and Cytokine Expression in Golden Hamsters (Mesocricetus auratus) Infected by Inocula with Different Leishmania (Viannia) braziliensis Concentrations

Contact Info

Product

Resources

About