Geographical and Temporal Variation in the Incidence and Mortality of Hepato–Pancreato–Biliary Primary Malignancies:1990-2017

Weaver, Andrew J.; Stafford, Reagan M; Hale, Jessica; Denning, David; Sanabria, Juan

doi:10.1016/j.jss.2019.07.031

Cited by 17 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognosis of patients with HCC is poor (43)(44)(45), thus understanding the pathogenesis, development, invasion, and metastasis of HCC cells remains vital. The results of the present study demonstrated high FBL expression in HCC tissues compared with Para-tumor tissues.…”

Section: Discussionmentioning

confidence: 99%

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Zhang

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the sixth most common cancer and third most common cause of cancer-associated mortality worldwide. Hepatectomy and liver transplantation are the main treatments for early HCC. Immunotherapy and targeted therapy for advanced HCC have become increasingly popular; however, their clinical benefits are limited. Thus, identification of novel therapeutic targets for advanced HCC remains essential. Fibrillarin (FBL) is an essential nucleolar protein that catalyzes the 2′-O-methylation of ribosomal RNAs. Recently, experimental data have suggested that FBL can influence breast-cancer progression. However, the association between FBL expression and HCC remains known. In the present study, the UALCAN database was used to assess FBL mRNA expression in HCC. Immunohistochemistry analysis was performed to detect FBL protein expression in 139 patients with HCC. In addition, bioinformatic analysis was performed using the UALCAN, the Database for Annotation, Visualization and Integrated Discovery, cBioportal and TargetScan databases. Data were analyzed using Kaplan-Meier curves and the log-rank test, and a Cox proportional hazards regression model. The results demonstrated that FBL expression was significantly higher in tumor tissues compared with para-tumor tissues. Furthermore, high FBL expression was significantly associated with tumor diameter and advanced TNM stage in HCC. High FBL expression also predicted a shorter overall survival time and disease-free survival time in patients with HCC. Bioinformatics analysis demonstrated that FBL may be regulated by methylation modification. In addition, analyses of functional annotations using the Gene Ontology database indicated that FBL-related genes were predominantly enriched in DNA repair and proliferation-related cell-signaling pathways. Notably, high FBL expression signified larger tumor diameter, advanced tumor stage and a poor prognosis. Taken together, the results of the present study suggest that FBL may be a potential target for HCC treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Zhang

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Gallbladder cancer (GBC) is the most common malignancy of the biliary tract and has an incidence that displays significant geographical variation [1 , 2] . GBC is an aggressive malignancy with a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer

Kai

Tanaka

Ide

et al. 2021

Translational Oncology

View full text Add to dashboard Cite

Highlights We examined CD1a-positive dendritic cell (CD1a-DC) infiltration in gallbladder cancer. The group with high CD1a-DC infiltration had fewer patients with distant metastasis. A high level of CD1a-DC infiltration was associated with longer overall survival. High CD1a-DC infiltration was also associated with longer disease-specific survival. S100-DC and tumor-infiltrating lymphocyte statuses were without effect on survival.

show abstract

“…There are a growing number of new cases worldwide. There is significant geographic variation, and more than half of the new cases are occurring in Eastern Asia, including Taiwan [2,3]. Gastric cancer, pancreatic cancer, and cholangiocarcinoma are also most common UGI cancer and cause of mortality in Taiwan [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Supportive Care and Unmet Needs in Upper Gastrointestinal Cancer Patients: Screening and Related Factors

Tseng

Hsieh

Hung

et al. 2021

IJERPH

View full text Add to dashboard Cite

Upper gastrointestinal (UGI) cancer treatment can cause physical and psychological distress and may result in unmet needs. The purposes of this study were to (1) examine the levels of gastrointestinal (GI) symptom distress, social support, and supportive care needs; (2) screen the priorities of unmet supportive care needs; and (3) identify the factors associated with supportive care needs among UGI cancer patients receiving chemotherapy. This cross-sectional study examined UGI cancer patients who received treatment from the outpatient chemotherapy department of a single cancer center in northern Taiwan. Questionnaires were used to collect data regarding GI symptom distress, social support, unmet needs, and supportive care needs. The top three unmet needs were “fears about the cancer spreading”, “uncertainty about the future”, and “being informed about things you can do to help yourself to get well”. Descriptive statistics examined the levels of GI symptom distress, social support, supportive care needs, and priorities of unmet supportive care needs. Stepwise regression was conducted to determine significant factors related to supportive care needs. Greater supportive care needs were found to be associated with higher levels of disease-related worries, increased treatment-related symptoms, and a lower level of physical performance. These factors explained 48.0% of the variance in supportive care needs. Disease-related worries and treatment-related symptoms strongly influence overall supportive care needs and each domain of supportive care needs. Symptom management and psychological support for patients receiving outpatient chemotherapy may help patients meet needs.

show abstract

Geographical and Temporal Variation in the Incidence and Mortality of Hepato–Pancreato–Biliary Primary Malignancies:1990-2017

Cited by 17 publications

References 29 publications

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Increased fibrillarin expression is associated with tumor progression and an unfavorable prognosis in hepatocellular carcinoma

Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer

Supportive Care and Unmet Needs in Upper Gastrointestinal Cancer Patients: Screening and Related Factors

Contact Info

Product

Resources

About