Geogenic PM10 exposure exacerbates responses to influenza infection

Clifford, Holly D.; Perks, Kara L.; Zosky, Graeme R.

doi:10.1016/j.scitotenv.2015.07.001

Cited by 24 publications

(20 citation statements)

References 33 publications

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“…Until now, sufficient evidence infers a relationship between air pollution and respiratory diseases. A study in Australia found that geogenic PM 10 exposure increases inflammation, impairs lung function, and increases viral load, exacerbating the response to respiratory viral infection [ 30 ]. Another study reported PM 10 seems to play an important role in the transmission of Q fever from infected animals to humans [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

Huang

Bian

et al. 2016

IJERPH

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Hand, foot, and mouth disease (HFMD) is a globally-prevalent infectious disease. However, few data are available on prevention measures for HFMD. The purpose of this investigation was to evaluate the impacts of temperature, humidity, and air pollution, particularly levels of particulate matter with an aerodynamic diameter 10 micrometers (PM10), on the incidence of HFMD in a city in Eastern China. Daily morbidity, meteorological, and air pollution data for Ningbo City were collected for the period from January 2012 to December 2014. A total of 86,695 HFMD cases were enrolled in this study. We used a distributed lag nonlinear model (DLNM) with Poisson distribution to analyze the nonlinear lag effects of daily mean temperature, daily humidity, and found significant relationships with the incidence of HFMD; in contrast, PM10 level showed no relationship to the incidence of HFMD. Our findings will facilitate the development of effective preventive measures and early forecasting of HFMD outbreaks.

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Section: Discussionmentioning

confidence: 99%

Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

Huang

Bian

et al. 2016

IJERPH

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“…Inhalation of geogenic PM is associated with increased mortality [9][10][11] and hospital admissions [12]. In experimental models, inhalation of geogenic PM results in oxidative stress, release of pro-inflammatory mediators, reduced lung mechanics and exacerbation of viral infections [13][14][15][16][17]. In vitro, geogenic PM increases interleukin (IL)-6 and IL-8 production in bronchial epithelial cells [18] and tumour necrosis factor-α (TNF-α) and reactive oxygen species (ROS) in alveolar macrophages [19].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, data on the effect of iron oxides are contradictory. Epidemiologically, there is some evidence to suggest that exposure to iron oxide causes respiratory morbidity and in vivo studies have shown strong associations between the iron concentration in geogenic PM, inflammation, deficits in lung mechanics and the capacity of the particles to exacerbate viral infection [17,16,15].…”

Section: Introductionmentioning

confidence: 99%

The Inflammatory Effect of Iron Oxide and Silica Particles on Lung Epithelial Cells

Williams

Zosky

2019

Lung

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Our understanding of the respiratory health consequences of geogenic (earth-derived) particulate matter (PM) is limited. Recent in vivo evidence suggests that the concentration of iron is associated with the magnitude of the respiratory response to geogenic PM. We investigated the inflammatory and cytotoxic potential of silica and iron oxide particles alone, and in combination, on lung epithelial cells. Methods Bronchial epithelial cells (BEAS-2B) were exposed to silica (quartz, cristobalite) and/or iron oxide (haematite, magnetite) particles. Cytotoxicity and cytokine production (IL-6, IL-8, IL-1β and TNF-α) were assessed by LDH assay and ELISA respectively. In subsequent experiments, the cytotoxic and inflammatory potential of the particles were assessed using alveolar epithelial cells (A549). Results After 24 hours of exposure, iron oxide did not cause significant cytotoxicity or production, nor did it augment the response of silica in the BEAS2-B cells. In contrast, while the silica response was not augmented in the A549 cells by the addition of iron oxide, iron oxide particles alone were sufficient to induce IL-8 production in these cells. There was no response detected for any of the outcomes at the 4 hour time point, nor was there any evidence of IL-1β or TNF-α production. Conclusions While previous studies have suggested that iron may augment silica induced inflammation, we saw no evidence of this in human epithelial cells. We found that alveolar epithelial cells produce pro-inflammatory cytokines in response to iron oxide particles, suggesting that previous in vivo observations are due to the alveolar response to these particles.

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“…Small particulates, especially those that are inhaled, have additionally been shown to increase susceptibility to respiratory viruses. Epidemiological studies have demonstrated that human exposure to inhaled diesel exhaust, cigarette and wood smoke, coal dust, silica, particulate matter 2.5 (PM 2.5 ), and air pollution of varied composition increases the severity and chance of acquiring respiratory infections (Ciencewicki and Jaspers 2007;Speizer et al 1980;Clifford et al 2015;Huang et al 2016;Jaspers et al 2009;Chen et al 2012;Becker and Soukup 1999;Ma et al 2017;Rabovsky et al 1986;Rebuli et al 2018). There is now consistent evidence to support that exposure to air pollution leads to severe lower respiratory infections, especially in children under 5 years of age.…”

Section: Multiple Environmental Stressorsmentioning

confidence: 99%

Nanomaterial Effects on Viral Infection

Chen

Humes

Saleh

et al. 2020

Interaction of Nanomaterials With the Immune System

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The potential for environmental and occupational exposures of populations to nanomaterials (NMs) has fostered concerns of associated adverse health effects, with a particular emphasis on pulmonary injury and disease. Many studies have revealed that several types of NMs can evoke a variety of biological responses, such as pulmonary inflammation and oxidative stress, which contribute to allergy, fibrosis, and granuloma formation. Less attention has been paid to health effects that may result from exposure to NMs and additional stressors such as pathogens, with a particular focus on susceptibility to viral infection. This chapter will summarize the current body of literature related to NMs and viral exposures with a primary focus on immune modulation. A summary of the studies performed and major findings to date will be discussed, highlighting proposed molecular mechanisms behind NM-driven host susceptibility, challenges, limitations, and future research needs. Specific mechanisms discussed include direct interaction between NMs and biological molecules, activation of pattern recognition receptors (PRRs) and related signaling pathways, production of oxidative stress and mitochondrial dysfunction, inflammasome activation, and modulation of lipid signaling networks.

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Geogenic PM10 exposure exacerbates responses to influenza infection

Cited by 24 publications

References 33 publications

Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

The Inflammatory Effect of Iron Oxide and Silica Particles on Lung Epithelial Cells

Nanomaterial Effects on Viral Infection

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