Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

Huang, Ruixue; Bian, Guolin; He, Tianfeng; Lv, Chen; Xu, Guozhang

doi:10.3390/ijerph13050481

“…The coefficient between PM 2.5 and HFMD is -0.37 while PM10 is -0.33. Our study is not consistent with the conclusion in the previous study (10), which showed no significant relationship between PM10 and HFMD (10).…”

Section: Discussioncontrasting

confidence: 99%

Forecasting hand, foot, and mouth disease in Shenzhen based on daily level clinical data and multiple environmental factors

Zhong

¹

,

Wu

²

,

Cai

³

et al. 2018

BST

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“…Undoubtedly, it is a key factor in the development of disease. In the first stage, we pooled the overall cumulative effect of 21 cities which showed an approximately "M"-shape which was consistent with the results in other studies (Minhang Distric: a suburban district of Shanghai; Ningbo city) [5,40]. The effect showed that the cumulative risk decreased when temperature was lower than 40th.…”

Section: Discussionsupporting

confidence: 79%

The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010-2013: A multicity study

Xu

¹

,

Hu

²

,

Jiao

³

et al. 2019

Preprint

0

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Background Hand, foot and mouth disease (HFMD) is a serious infectious disease, which has become a public health problem. Previous studies have shown that temperature may influence the incidence of HFMD, but most only focus on single city and the results are highly heterogeneous. Therefore, a multicity study was conducted to explore the association between temperature and HFMD in different cities and search for modifiers that influence the heterogeneity. Methods We collected daily cases of childhood HFMD (aged 0-5 years) and meteorological factors of 21 cities in Guangdong Province in the period of 2010-2013. Distributed lag non-linear model (DLNM) with quasi-Poisson was adopted to quantify the effects of temperature on HFMD in 21 cities. Then the effects of each city were pooled by multivariate meta-analysis to obtain the heterogeneity among 21 cities. Potential city-level factors were included in meta-regression to explore effect modifiers. Results A total of 1,048,574 childhood cases were included in this study. There was a great correlation between daily childhood HFMD cases and temperature in each city, which was non-linear and lagged. High heterogeneity was showed in the associations between temperature and HFMD in 21 cities. The pooled temperature-HFMD association was peaking at the 79th percentile of temperature with relative risk (RR) of 2.474(95%CI: 2.065-2.965) as compared to the median temperature. Latitude was the main modifier for reducing the heterogeneity to 69.28% revealed by meta-analysis. Conclusions There was a strong non-linear and lagged correlation between temperature and HFMD. Latitude was strongly associated with the relationship between temperature and HFMD. Meanwhile, it had an effect on modifying the relationship. These findings can conducive to local governments developing corresponding preventive measures.

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“…The epidemiological triangle emphasizes that pathogens, hosts and the environment are the three elements of disease, and that human health can be maintained unless the balance is broke. Besides, temperature can affect the survival and transmission of pathogen as well as human activities and behaviors [40][41]. Undoubtedly, it is a key factor in the development of disease.…”

Section: Discussionmentioning

confidence: 99%

The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010-2013: A multicity study

Xu

¹

,

Hu

²

,

Jiao

³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Hand, foot and mouth disease (HFMD) is a serious infectious disease, which has become a public health problem. Previous studies have shown that temperature may influence the incidence of HFMD, but most only focus on single city and the results are highly heterogeneous. Therefore, a multicity study was conducted to explore the association between temperature and HFMD in different cities and search for modifiers that influence the heterogeneity. Methods We collected daily cases of childhood HFMD (aged 0-5 years) and meteorological factors of 21 cities in Guangdong Province in the period of 2010-2013. Distributed lag non-linear model (DLNM) with quasi-Poisson was adopted to quantify the effects of temperature on HFMD in 21 cities. Then the effects of each city were pooled by multivariate meta-analysis to obtain the heterogeneity among 21 cities. Potential city-level factors were included in meta-regression to explore effect modifiers. Results A total of 1,048,574 childhood cases were included in this study. There was a great correlation between daily childhood HFMD cases and temperature in each city, which was non-linear and lagged. High heterogeneity was showed in the associations between temperature and HFMD in 21 cities. The pooled temperature-HFMD association was peaking at the 79th percentile of temperature with relative risk (RR) of 2.474(95%CI: 2.065-2.965) as compared to the median temperature. Latitude was the main modifier for reducing the heterogeneity to 69.28% revealed by meta-analysis. Conclusions There was a strong non-linear and lagged correlation between temperature and HFMD. Latitude was strongly associated with the relationship between temperature and HFMD. Meanwhile, it had an effect on modifying the relationship. These findings can conducive to local governments developing corresponding preventive measures.

show abstract

Effects of Meteorological Parameters and PM10 on the Incidence of Hand, Foot, and Mouth Disease in Children in China

Cited by 48 publications

References 30 publications

Forecasting hand, foot, and mouth disease in Shenzhen based on daily level clinical data and multiple environmental factors

Forecasting hand, foot, and mouth disease in Shenzhen based on daily level clinical data and multiple environmental factors

The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010-2013: A multicity study

The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010-2013: A multicity study

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