The Dulate arc, located in East Junggar (NW China) in the southern Central Asian orogenic belt, records a Devonian magmatic arc evolution, offering a window to understanding the orogenic processes of the Central Asian orogenic belt. Here we present new geochemical and isotopic data for Late Devonian high-Mg andesite (HMA) and Nb-enriched basalt (NEB) suites from the Qiakuerte area, East Junggar. The HMA samples are typical subduction-related volcanic rocks. They have SiO2 contents ranging from 53.30 to 54.59 wt%, high MgO (5.0–5.26 wt%), and high Mg# values (~55) and show enrichments in large ion lithophile elements (LILEs) and depletions in high field strength elements (HFSEs). The HMA samples have high (La/Yb)N ratios and Sr/Y (~6.5 and 50–59, respectively) with no Eu anomalies. The HMA samples have high Na2O (~3.3 wt%) and low K2O (~2.5 wt%) and Th (~2.4 ppm) contents, combined with positive εNd(t) and low (87Sr/86Sr)i values. These characteristics suggest that the samples were formed mainly through interactions between subducted oceanic melts and mantle peridotites. Compared to normal arc basalts, the NEB samples have higher concentrations of Nb (~20 ppm), higher primitive mantle–normalized Nb/La (0.50–0.58), and higher ratios of Nb/U (9.4–14.6). The NEB samples also have positive εNd(t) and low (87Sr/86Sr)i values, indicating that their source was mantle wedge that had been metasomatized by slab melt. Considering the widespread presence of A-type granites, the abnormally high heat flow, and the tectonic characteristics of East Junggar, we conclude that a slab window created by the subduction of an ocean ridge was responsible for the melting of slab and the formation of the NEB-HMA suites. These processes may have also played a key role in the tectonic evolution processes of East Junggar during the Late Devonian.