Genus Ziziphus: A comprehensive review on ethnopharmacological, phytochemical and pharmacological properties

Maaiden, Ezzouhra El; Kharrassi, Youssef El; Qarah, Nagib A. S.; Essamadi, Abdel Khalid; Moustaid, Khadija; Nasser, Boubker

doi:10.1016/j.jep.2020.112950

Cited by 53 publications

(53 citation statements)

References 86 publications

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“…According to The Plant List (2013), the genus Ziziphus encompasses 58 accepted plant species and are widely used for their therapeutic properties. Their plants are small trees were thorny shrubs, which are generally distributed in the subtropical and warm temperate regions of the world [1]. Among the most important plants of this genus, Z. lotus known as Jujube belongs to the angiosperm Rhamnaceae family.…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

et al. 2021

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Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules.

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Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

et al. 2021

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“…Among these substances, polyphenols from jujube, secondary metabolites of plants, are important determinants of the nutritional and organoleptic qualities of Zizyphus lotus [21,22]. Several bioactive compounds extracted from jujubes have attracted the attention of many researchers due to their important biological actions, including antioxidant [19,23], enzyme inhibitory [24,25], antiproliferative and cytotoxic effects [24,26], anti-inflammatory, and other effects [27][28][29], which can be used in the food, pharmaceutical, and cosmetic industry.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

et al. 2020

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Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant against DPPH (EC50 = 0.39 µg/mL) and FRAP (1670.42 ± 6.5 mg/100 g). Additionally, it possesses acetylcholinesterase (AChE) inhibitory effect (IC50 = 0.93 ± 0.01 mg/mL) and HMGR inhibition (45.41%) using 100 µg/mL. The extract significantly inhibits cell proliferation on the MCF-7 and HepG2 tumor cell lines with an IC50 values of <0.05 and 3 ± 0.55 mg/mL, respectively. Therefore, the ultrasound method can be considered a method for obtaining a significant anticancer activity with respect to the lines and therefore makes it possible to recover a maximum of phenolic compounds in less time with an AChE and HMGR inhibitory activity. Thus, it can be suggested that Zls extract is a promising fruit for the development of supplementary dietary due to its potential behaviour as nutraceutical.

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“…includes about 58 species of spiny shrubs and trees (El Maaiden et al 2020). It is extensively used in folk and traditional medicine in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetes, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases (El Maaiden et al 2020). Ziziphus mauritiana Lam., called Indian jujube or ber, is a tropical shrub or small tree, of considerable commercial importance and is widely cultivated for its fruits.…”

Section: Host Plant Ecologymentioning

confidence: 99%

Natural history of Platypria (Platypria) hystrix (Fabricius, 1798) on Fabaceae host plants, with notes on other Platypria species in India (Chrysomelidae, Cassidinae, Hispini)

Ranade¹,

Prathapan²,

Ghate³

et al. 2021

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The leaf-beetle genus Platypria Guérin-Méneville, 1840 comprises two subgenera and 34 species (Chrysomelidae: Cassidinae: Hispini). Host plants are documented for eight species and indicate mostly perennial species of Fabaceae and Rhamnaceae. Larvae and pupae have been documented for two Platypria species. This paper presents novel natural history data, based on a field study of populations of Platypria (Platypria) hystrix (Fabricius, 1798) on Erythrina stricta Roxb. and Pueraria phaseoloides (Roxb.) Benth. in Kerala, south India and on Erythrina variegata L., Pueraria montana var. lobata (Willd.) Maes. & S. Almeida and Mucuna pruriens (L) DC in Assam, northeast India. Three new Fabaceae hosts are reported for P. (P.) hystrix. Brief notes and new host records, based on field observations, are also provided for the other three species of Platypria in India – P. (P.) chiroptera Gestro, 1899, P. (P.) echidna Guérin-Méneville, 1840 and P. (P.) erinaceus (Fabricius, 1801). Platypria females slit the leaf to lay a single egg which is covered with secretions that harden as an ootheca, the egg covering in Cassidinaes. l. There are five larval stages, each with the typical ‘hispine’ mining form and behaviour – a flattened cream-coloured body, chitinised head capsule and claws, and feeding on mesophyll and leaving irregular blotch mines on the host leaves. Pupation occurs in an independent pupal mine and lasts about a week. These observations suggest new potential phylogenetic character hypotheses that can stimulate better data collection on leaf-mining Cassidinae and help resolve evolutionary patterns amongst these basal mining genera.

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Genus Ziziphus: A comprehensive review on ethnopharmacological, phytochemical and pharmacological properties

Cited by 53 publications

References 86 publications

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

Ultrasound Assisted Extraction of Phenolic Compounds from a Jujube By-Product with Valuable Bioactivities

Natural history of Platypria (Platypria) hystrix (Fabricius, 1798) on Fabaceae host plants, with notes on other Platypria species in India (Chrysomelidae, Cassidinae, Hispini)

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