Genus Molluscipoxvirus

Bugert, Joachim J.

doi:10.1007/978-3-7643-7557-7_5

Cited by 8 publications

(6 citation statements)

References 113 publications

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“…It is specific to humans and is only known to replicate in basal keratinocytes. MOCV causes molluscum contagiosum, which is a common skin disease characterized by wart-like skin lesions that affects mainly children and immunocompromised people (reviewed in (Bugert, 2007)). The genome of MOCV comprises 190 kb, codes for an estimated 182 proteins, and lacks many genes commonly found in other poxviruses (Senkevich et al, 1996; Senkevich et al, 1997).…”

Section: Molluscum Contagiosum Virusmentioning

confidence: 99%

Poxviruses and the evolution of host range and virulence

Haller¹,

Chen²,

McFadden³

et al. 2014

Infection, Genetics and Evolution

244

257

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Poxviruses as a group can infect a large number of animals. However, at the level of individual viruses, even closely related poxviruses display highly diverse host ranges and virulence. For example, variola virus, the causative agent of smallpox, is human-specific and highly virulent only to humans, whereas related cowpox viruses naturally infect a broad spectrum of animals and only cause relatively mild disease in humans. The successful replication of poxviruses depends on their effective manipulation of the host antiviral responses, at the cellular-, tissue- and species-specific levels, which constitutes a molecular basis for differences in poxvirus host range and virulence. A number of poxvirus genes have been identified that possess host range function in experimental settings, and many of these host range genes target specific antiviral host pathways. Herein, we review the biology of poxviruses with a focus on host range, zoonotic infections, virulence, genomics and host range genes as well as the current knowledge about the function of poxvirus host range factors and how their interaction with the host innate immune system contributes to poxvirus host range and virulence. We further discuss the evolution of host range and virulence in poxviruses as well as host switches and potential poxvirus threats for human and animal health.

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Section: Molluscum Contagiosum Virusmentioning

confidence: 99%

Poxviruses and the evolution of host range and virulence

Haller¹,

Chen²,

McFadden³

et al. 2014

Infection, Genetics and Evolution

244

257

View full text Add to dashboard Cite

show abstract

“…2 MC typically presents as one or more umbilicated, smooth, fleshcoloured, dome-shaped lesions, 3 and is usually diagnosed on clinical examination by a GP or dermatologist. 4 The condition can impact on quality of life, with around 1 in 10 children experiencing a substantial effect on their quality of life.…”

Section: Introductionmentioning

confidence: 99%

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care

et al. 2015

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“…MC typically presents as one or more umbilicated, smooth, flesh-coloured, domed shaped lesions (3), and is usually diagnosed on clinical examination by a general practitioner or dermatologist (4). The condition can impact on quality of life, with around one in 10 children experiencing a substantial effect on their quality of life (5).…”

Section: Introductionmentioning

confidence: 99%