Genus <i>Streptomyces</i>: Recent advances for biotechnological purposes

Júnior, Apolonio Alves de Lima; Sousa, Ednan Cardoso de; Oliveira, Thales Henrique Barbosa de; Santana, Raphael Carlos Ferrer de; Silva, Silvia Katrine Rabelo da; Coelho, Luana Cassandra Breitenbach Barroso

doi:10.1002/bab.2455

Cited by 2 publications

(1 citation statement)

References 119 publications

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“…Furthermore, Streptomyces strains have also become the important resource of antitumor drugs, immunosuppressive agents, or other pharmaceutical molecules with a broad range of bioactivities and low toxicities toward human body [3].…”

Section: Introductionmentioning

confidence: 99%

Genome-based analysis for the biosynthetic potential of Streptomyces sp. FIM 95-F1 producing antifungal antibiotic Scopafungin

Fei,

Wenzhou,

Yangjun

et al. 2023

Preprint

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Background: Marine microbial members of the genus Streptomyces are an excellent source for novel secondary metabolites. However, publicly available complete genome sequences of marine streptomycetes are still limited. Here, 16S rRNA phylogeny analysis and morphological characterization of a marine Streptomyces sp. FIM95-F1 was demonstrated. Meanwhile, the complete genome sequence of this strain was also presented and employed to examine the biosynthetic potential by informatic analysis. Results: The 16S rRNA phylogeny analysis and morphological characterization revealed that isolated strain FIM95-F1 belonged to the genus of Streptomyces and had the closest genetic relative with S. antimycoticus. To investigate the biosynthesis potential of this strain, a high quality complete genome (9.7 Mb) of Streptomyces sp. FIM95-F1 was obtained with a G + C content of 71.04% and 8236 protein coding genes. The in silico analysis revealed presence of 42 biosynthetic gene clusters (BGCs), the most of which showed similarity with the known and novel BGCs that are responsible for the biosynthesis of previously known and novel bioactive agents of microbial origin. Specifically, the BGC of the antifungal antibiotic scopafungin produced by strain FIM95-F1, named as spf BGC, was characterized. Detailed comparison of the scopafungin BGC with niphimycin BGC has suggested the proposed common pathway for scopafungin biosynthesis and determined the absolute configuration of the stereocenters of scopafungin. One of the interesting outcomes of this study was to discover at least two novel BGCs (Cluster 26 and Cluster 32) present in biosynthetic gene clusters, suggesting that Streptomycessp. FIM95-F1 has the potential to be developed as a producer for novel secondary metabolites production. Conclusions: This study highlights the biosynthesis potential of strain FIM95-F1 related to the secondary metabolite production using genomic based approach. Our results indicate that Streptomycessp. FIM95-F1 has great potential to produce a variety of potentially valuable known and novel bioactive compounds for drug discovery.

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Section: Introductionmentioning

confidence: 99%

Genome-based analysis for the biosynthetic potential of Streptomyces sp. FIM 95-F1 producing antifungal antibiotic Scopafungin

Fei,

Wenzhou,

Yangjun

et al. 2023

Preprint

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Actinomycetes Associated with Arthropods as a Source of New Bioactive Compounds

Olano,

Rodríguez

2024

CIMB

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Antimicrobial resistance is one of the main global threats to human health in the 21st century due to the rapid appearance of bacterial resistance and the lack of novel bioactive compounds. Natural products, especially from Actinomycetes, remain the best source to refill the drug industry pipeline. Different strategies have been pursued to increase the chances of discovering new molecules, such as studying underexplored environments like arthropod symbionts, which represent a relevant reservoir for active metabolites. This review summarizes recent research on the identification of bioactive molecules produced by Actinomycetes associated with arthropods’ microbiome. The metabolites have been categorized based on their structural properties and host, highlighting that multidisciplinary approaches will be the key to fully understanding this complex relationship.

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Genus Streptomyces: Recent advances for biotechnological purposes

Cited by 2 publications

References 119 publications

Genome-based analysis for the biosynthetic potential of Streptomyces sp. FIM 95-F1 producing antifungal antibiotic Scopafungin

Genome-based analysis for the biosynthetic potential of Streptomyces sp. FIM 95-F1 producing antifungal antibiotic Scopafungin

Actinomycetes Associated with Arthropods as a Source of New Bioactive Compounds

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