Genus <i>Caulophyllum</i>: An Overview of Chemistry and Bioactivity

Xia, Yueyuan; Li, Guoyu; Liang, Jun; Yang, Bing‐You; Lü, Shaowa; Kuang, Hai‐Xue

doi:10.1155/2014/684508

Cited by 11 publications

(13 citation statements)

References 72 publications

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“…It is distributed in the northeast Tibet, Hubei provinces of China, native communities of North America, Its root and rhizome have beenused to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation [ 2 ]. Modern pharmacological studies have demonstrated that alkaloids and triterpenoidsaponins are responsible for its major biological function as an anti-inflammatory [ 3 ]. As part of our effort to search for novel triterpene from C. robustum Maxim, we report here the isolation and structure determination of the three new terpenoids: ( 1 ) 23-hydroxy-3,19-dioxo-olean-12-en-28-oic-acid; ( 2 ) 23-hydroxy-3,11-dioxo-olean-12-en-28-oic acid; and ( 3 ) 16 α ,23-dihydroxy-3-oxo-olean-12-en-28-oic acid ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

et al. 2018

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Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives (1–3), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods. They were identified as (1) 23-hydroxy-3,19-dioxo-olean-12-en-28-oic-acid; (2) 23-hydroxy-3,11-dioxo-olean-12-en-28-oic acid; and (3) 16α,23-dihydroxy-3-oxo-olean-12-en-28-oic acid. Compounds (1–10) inhibited the LPS-activated NO production in RAW264.7 cells. Furthermore, the anti-inflammatory characteristics of these compounds were confirmed on the basis of decreases in iNOS and NF-κB protein expression in RAW264.7 cells.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

et al. 2018

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“…C. robustum consists of more than 60 constituents, including sterols, triterpenes, glycosides, and alkaloids. Triterpene saponins are believed to be the major bioactive compounds contributing to the anti-inflammatory effects on RA [ 10 ]. Triterpene saponins constitute an important class of potential pharmacological agents possessing a range of different physiological activities including anticancer, anticoagulation, anti-inflammation, antibacterial, analgesic, and comparative immune-modulation activity [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Historically, C. robustum is a traditional Chinese herb used in the treatment of RA [ 10 ]. It is acrid and bitter in taste and warm in nature.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Effect of Caulophyllum robustum on Collagen‐Induced Arthritis and Regulation of Nitric Oxide, NF‐κB, and Proinflammatory Cytokines In Vivo and In Vitro

Wang

Guo

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Caulophyllum robustum Maxim (C. robustum) has commonly been used as traditional Chinese medicine for the treatment of rheumatic pain and rheumatoid arthritis (RA) in China. This paper first investigated the anti-inflammation effect of C. robustum extraction (CRME) on RAW264.7 cells stimulated by lipopolysaccharide (LPS) and gene expression levels of inflammatory factors. Moreover, we first evaluated the anti-RA effects of CRME using collagen-induced arthritis (CIA) in DBA/1J mice, and the incidence, clinical score, and joint histopathology were evaluated. The levels of IL-1, IL-6, TNF-α, and PGE2 inflammatory factors in sera of mice were detected by enzyme-linked immunosorbent assay. The expression of NF-κB p65 in the joint was tested by immune histochemical technique. The results showed that, compared with the model group, CRME significantly improved symptoms of the arthritis index, limb swelling, and histological findings by decreasing synovial membrane damage, the extent of inflammatory cell infiltration, and the expansion of capillaries in CIA mice. The results also showed that CRME can reduce the levels of IL-1, IL-6, TNF-α, and PGE2 and inhibit the expression of NF-κB p65. All these results indicated the anti-inflammatory efficacy of CRME as a novel botanical extraction for the treatment of RA.

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“…(21) Magnoflorine, taspine, and boldine, belonging to aporphine alkaloids, are found in Caulophyllum. (22) Typical quinolizidine alkaloids are also present in this genus. Alkaloids with piperidine-acetophenone conjugates, rare in the plant kingdom, are only found in Caulophyllum and Boehmeria.…”

Section: Nandinoideae Subfamilymentioning

confidence: 97%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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Ranunculales is an order of angiosperms, containing 7 families, i.e., Ranunculaceae (at least 50 genera, >2,000 species), Berberidaceae (17 genera, 650 species), Menispermaceae (65 genera, >350 species), Lardizabalaceae (9 genera, 50 species), Circaeasteraceae (2 species), Papaveraceae (38 genera, >700 species), and Eupteleaceae (2 species, Appendix 1). Ranunculales belongs to the basal eudicots, in which it is the most basal clade; its widely known members include poppies, barberries, monseed, akebia and buttercupss. The chemodiversity of Ranunculaceae, the fl agship family of Ranunculales, and their correlation with the biodiversity and pharmacotherapy, have been systematically reviewed by us in the context of pharmacophylogeny. (1) In recent years, the research enthusiasm for the other 4 major Ranunculales families has been growing rapidly, as plants of these families also meet human needs for food, fl avours, fragrances, and not the least, medicines during long history. Ranunculales plants form the basis of sophisticated traditional medicine systems, e.g., Chinese medicine (CM) and Ayurveda medical system. (2) These systems of medicine give rise to some important Ranunculalesbased drugs still in use today. (3,4) According to incomplete statistics, 573 Ranunculaceae and 308 Berberidaceae species were in medicinally hot nodes; (4) the therapeutic efficacy of 2 families differed substantially. For instance, up to 361 Chinese Ranunculaceae species are used against musculoskeletal diseases, followed by 321 against hepatic diseases, 242 against circulatory diseases, and 210 against skin diseases, etc.; in contrast, as many as 251 Chinese Berberidaceae species are used against eyesight diseases, followed by 249 against hepatic diseases, 242 against digestive diseases and 90 against oral diseases, etc. Nevertheless, except Ranunculaceae, the

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Genus Caulophyllum: An Overview of Chemistry and Bioactivity

Cited by 11 publications

References 72 publications

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

Pharmacological Effect of Caulophyllum robustum on Collagen‐Induced Arthritis and Regulation of Nitric Oxide, NF‐κB, and Proinflammatory Cytokines In Vivo and In Vitro

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

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