Gentisyl alcohol and homogentisic acid: <i>Plasmodium falciparum</i> dihydroorotate dehydrogenase inhibitors isolated from fungi

Abstract

Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC 50 value of 3.4 µ µ µ µ µM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC 50 value of 47.6 µ µ µ µ µM.