Gentamicins

Abou‐Zeid, A. A.; Shehata, Yousef M.

doi:10.1016/s0044-4057(77)80051-8

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Surfactant molecules ( 20–33 ) were tested for activity toward E. coli and S. aureus as antibacterial and A. flavus and C. albicans as antifungal using the cap assay method .…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

El‐Sayed

Katouah

2019

Journal of Heterocyclic Chem

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This study aims to synthesis of condensed and non‐condensed heterocyclic rings with long fatty chains as surface active biological compounds. 2‐Cyano‐3‐(dimethylamino)‐N‐octadecylacrylamide (5) was used to synthesize pyrimidine, pyran, and other condensed products by interacting with appropriate chemical reagents. These compounds were transferred to nonionic surface‐active agents by condensation with propylene oxide. The surface and biological properties showed that these compounds have a high solubility that helps them in easy absorption and adsorption with other compounds. In addition, they have a high ability to decrease the surface tension of the liquids, good wetting, and emulsification power, which can be used at different temperatures without losing their surface or biological properties and enable them for use in industrial and pharmaceutical purposes easily.

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“…Surfactant molecules ( 20–33 ) were tested for activity toward E. coli and S. aureus as antibacterial and A. flavus and C. albicans as antifungal using the cap assay method .…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

El‐Sayed

Katouah

2019

Journal of Heterocyclic Chem

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“…Гентамицина сульфат -антибиотик широкого спектра действия из группы аминогликозидов. Его бактерицидное действие заключается в связывании с 30S субъединицей рибосомы бактерий и нарушении синтеза белка грамотрицательных микроорганизмов (Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae) и грамположительных микроорганизмов (Staphylococcus aureus) [41]. Результаты недавних исследований чувствительности к гентамицину штаммов S. аureus показали, что на протяжении последних десятилетий не наблюдается отрицательной динамики в отношении резистентности, в частности S. aureus [42][43].…”

Section: лечениеunclassified

Steroid-refractory hand eczema: treatment experience

et al. 2022

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Hand eczema is a common multi-etiological disease manifested by evolutionary polymorphism of rashes. Hand eczema develops against the background of altered reactivity and genetic predisposition under the adverse effects of endogenous and exogenous factors. Hand eczema has a chronic course and is characterized by a wide range of clinical manifestations. The prevalence of eczematous lesions of the hands among the adult population is 1–2%, and among all skin diseases – 30–40%. The disease has an extremely negative impact on the quality of life, ability to work, career prospects and the social status of a person. The long course of eczematous lesions of the hands can be complicated by a secondary infection: bacterial and mycotic flora. Therefore, choosing the right and effective treatment for hand eczema is a particularly difficult task for a dermatologist. In recent years, a multicomponent drug based on gentamicin sulfate, dexpanthenol, mometasone furoate and econazole nitrate has been widely used for the treatment of hand eczema due to its high efficacy, tolerability, and safety. The use of this multicomponent drug in monotherapy for hand eczema is effective, leads to clinical remission and restoration of the quality of life of patients and is not accompanied by side effects and complications. This review focuses on the epidemiology, clinical features, and treatment options for hand eczema. Clinical experience with the use of a multicomponent drug in patients with hand eczema complicated by infection is also given.

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“…The synthesized compounds 19–31 were screened for their antibacterial activity against the gram‐positive bacteria ( B. subtilis ), gram‐negative bacteria ( E. coli ), fungi ( A. niger ), and yeast ( C. albicans ). The results were recorded by measuring the inhibition zone diameters and are tabled in Table .…”

Section: Preparation Of Nonionic Surface Active Agentsmentioning

confidence: 99%

Synthesis of Some New Thiazole, Oxazole, Pyrimidine and Pyridazine Derivatives from 2‐cyano‐N‐octadecyl‐acetamide as Antimicrobial and Surface Active Agents

El‐Sayed

Ahmed

2015

Journal of Heterocyclic Chem

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The motivation behind the present work is to synthesize some nonionic surfactants containing heterocyclic nucleus with intermediate fatty compounds for improving their surfactants properties. 2‐Cyano‐N‐octadecylacetamide was utilized as key intermediate for the synthesis of some new thiazole, pyrazole, oxazole, pyrimidine, 1,3‐dithiolane, thiophene, coumarin, oxazine and pyridazine derivatives. The newly synthesized compounds undergo propoxylation using propylene oxide to afford nonionic surface active agents. The antimicrobial and surface activities were evaluated and characterized through investigations of their spreading behavior in monolayer on water.

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Gentamicins

Cited by 5 publications

References 21 publications

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

Synthesis of Pyrimidine and Pyran Derivatives with the Related Systems and the Study of Their Behavior in the Liquid Solutions

Steroid-refractory hand eczema: treatment experience

Synthesis of Some New Thiazole, Oxazole, Pyrimidine and Pyridazine Derivatives from 2‐cyano‐N‐octadecyl‐acetamide as Antimicrobial and Surface Active Agents

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