Gentamicin resistance gene transfer from Enterococcus faecalis and E. faecium to Staphylococcus aureus, S. intermedius and S. hyicus

Noble, W. C.; Rahman, Mary; Karadec, T.; Schwarz, Štefan

doi:10.1016/0378-1135(96)00057-0

Cited by 23 publications

(13 citation statements)

References 24 publications

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“…Thus it should be noted that our current knowledge on the role of isolates of different staphylococcal species of animal origin as recipients for resistance plasmids and transposons is very limited. A few mating experiments using naturally occurring S. intermedius and S. hyicus isolates as recipients with enterococcal donors identified the S. intermedius isolates as very poor recipients for resistance plasmids whereas transposons were readily accepted [52]. This observation was in accordance with the findings on the preferential occurrence of other transposonborne resistance genes, such as tet(M) [80,91] and erm(B) [20] in S. intermedius.…”

Section: Horizontal Gene Transfersupporting

confidence: 82%

“…This gene is associated with the composite transposon Tn4001 [65] which is frequently found on conjugative plasmids in enterococci. Plasmid and chromosomal locations of this transposon in staphylococci have been determined as the result of conjugative transfer events between enterococci and S. aureus, S. intermedius and S. hyicus isolates [52]. More recently, Tn4001-like elements in which IS256 was structurally deleted by the insertion of copies of IS257 were detected on conjugative and non-conjugative plasmids in avian isolates of S. sciuri and S. warneri [31].…”

Section: Resistance To Aminoglycosides and Aminocyclitolsmentioning

confidence: 99%

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Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius

et al. 2001

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-Besides their role as commensals on the skin and mucosal surfaces, staphylococci may be involved in a wide variety of diseases in animals. Staphylococcal infections in animals are mainly treated with antimicrobial agents and as a consequence, staphylococci from animal sources have developed and/or acquired resistance to the respective antimicrobial agents. Resistance statistics obtained from national monitoring programmes on staphylococci from cattle and pigs, but also from surveillance studies on staphylococci involved in diseases in dogs are reported and reviewed with regard to their comparability. This review mainly focusses on the genetic basis of antimicrobial resistance in staphylococci of animal origin. Particular attention is paid to resistance to those antimicrobial agents which are most frequently used in veterinary medicine, but also to antimicrobial agents, such as chloramphenicol and mupirocin, which are used in specific cases for the control of staphylococcal infections in pets and companion animals. In addition, plasmids and transposons associated with the respective resistance properties and their ways of spreading between members of the same or different staphylococcal species, but also between staphylococci and other gram-positive bacteria, are described.antimicrobial resistance / Staphylococcus / animal origin / epidemiology / horizontal gene transfer Vet. Res. 32 (2001) 341

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Section: Horizontal Gene Transfersupporting

confidence: 82%

Section: Resistance To Aminoglycosides and Aminocyclitolsmentioning

confidence: 99%

Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius

et al. 2001

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“…Plasmid analyses from additional isolates and conjugation experiments will be needed to investigate this possibility. Although genetic transfer between E. faecium and S. aureus has been described previously (29), the transfer consisted of chromosomal DNA fragments and not plasmids. It is possible that among the many isolates associated with this infection, there may have been an E. faecalis strain with a plasmid identical or very similar to the E. faecium plasmid that harbored all of the genes transferred to the recipient MRSA isolate and that this strain was not among the colonies selected for characterization.…”

Section: Discussionmentioning

confidence: 97%

“…The genetic exchange of antimicrobial resistance determinants among enterococci and staphylococci is well documented (16,18,29,30). The resistance genes are typically found on conjugative plasmids or transposons.…”

mentioning

confidence: 99%

High-Level Vancomycin-Resistant Staphylococcus aureus Isolates Associated with a Polymicrobial Biofilm

Weigel

Donlan

Shin

et al. 2007

Antimicrob Agents Chemother

218

142

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Glycopeptides such as vancomycin are the treatment of choice for infections due to methicillin-resistant Staphylococcus aureus. This study describes the identification of high-level vancomycin-resistant S. aureus (VRSA) isolates in a polymicrobial biofilm within an indwelling nephrostomy tube in a patient in New York. S. aureus, Enterococcus faecalis, Enterococcus faecium, Micrococcus species, Morganella morganii, and Pseudomonas aeruginosa were isolated from the biofilm. For VRSA isolates, vancomycin MICs ranged from 32 to >128 g/ml. VRSA isolates were also resistant to aminoglycosides, fluoroquinolones, macrolides, penicillin, and tetracycline but remained susceptible to chloramphenicol, linezolid, rifampin, and trimethoprim-sulfamethoxazole. The vanA gene was localized to a plasmid of ϳ100 kb in VRSA and E. faecium isolates from the biofilm. Plasmid analysis revealed that the VRSA isolate acquired the 100-kb E. faecium plasmid, which was then maintained without integration into the MRSA plasmid. The tetracycline resistance genes tet(U) and tet(S), not previously detected in S. aureus isolates, were identified in the VRSA isolates. Additional resistance elements in the VRSA isolate included a multiresistance gene cluster, ermB-aadE-sat4-aphA-3, msrA (macrolide efflux), and the bifunctional aminoglycoside resistance gene aac(6)-aph(2؆)-Ia. Multiple combinations of resistance genes among the various isolates of staphylococci and enterococci, including vanA, tet(S), and tet(U), illustrate the dynamic nature of gene acquisition and loss within and between bacterial species throughout the course of infection. The potential for interspecies transfer of antimicrobial resistance genes, including resistance to vancomycin, may be enhanced by the microenvironment of a biofilm.

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“…Both interspecies and intraspecies transmission of antimicrobial resistance have been demonstrated by Muhammad et al (1993) and Licht et al (1999). Resistance transmission from L. monocytogenes to S. aureus was described by Lemaitre et al (1998); from Enterococcus faecalis and E. faecium to S. aureus, S. hyicus, and S. intermedius by Noble et al (1996); and from E. coli to S. aureus and L. monocytogenes by Trieu-Cuot et al (1993). Therefore, these samples which were contaminated with two foodborne pathogens in our study may cause transmission of resistance among different genera.…”

mentioning

confidence: 91%

Prevalence and Antimicrobial Resistance of Foodborne Pathogens Isolated from Food Products in China

Chao

Zhou

Jiao

et al. 2007

Foodborne Pathogens and Disease

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This study was undertaken to investigate the prevalence of Salmonella, Listeria monocytogenes, Staphylococcus aureus, Vibrio parahaemolyticus, and Escherichia coli O157:H7 in Chinese food products. The prevalence of these pathogens was 3.46%, 5.79%, 7%, 0.24%, and 0%, respectively. Raw meats were mainly contaminated with Salmonella (39/365, 10.7%), L. monocytogenes (26/365, 7.1%), and S. aureus (40/365, 11%), while cooked food products were mainly contaminated with L. monocytogenes (45/384, 11.7%) followed by S. aureus (12/384, 3.1%), and raw milk was mainly contaminated with S. aureus (34/209, 16.3%) and Salmonella (4/209, 1.9%). Antimicrobial resistance was evaluated in Salmonella, L. monocytogenes, and S. aureus. Antimicrobial resistance for L. monocytogenes was most frequently observed for cefotaxime (51/72, 70.8%) followed by furazolidone (40/72, 55.6%). Multiple resistance (resistance to >or=2 antibiotics) was observed for 63.9% (46/72) of L. monocytogenes isolates. Resistance of Salmonella was most frequently observed to amoxicillin (11.6%), ticarcilline (11.6%), cephalothin (11.6%), and cefuroxime (11.6%). Multiple resistance was observed for 16.3% (7/43) of the Salmonella isolates. Staphylococcus aureus was resistant to penicillin (93.1%) followed by tetracycline and oxacillin COAG (49.4% and 37.9%, respectively). About 79% (69/87) of S. aureus isolated demonstrated multiple resistance. The data showed that raw meat, cooked food products, and raw milk were most commonly contaminated with foodborne pathogens and many pathogens were resistant to different antibiotics. The study provided useful information for assessment of the possible risk posed to Chinese consumers, which has significant public health impact in China.

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Gentamicin resistance gene transfer from Enterococcus faecalis and E. faecium to Staphylococcus aureus, S. intermedius and S. hyicus

Cited by 23 publications

References 24 publications

Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius

Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius

High-Level Vancomycin-Resistant Staphylococcus aureus Isolates Associated with a Polymicrobial Biofilm

Prevalence and Antimicrobial Resistance of Foodborne Pathogens Isolated from Food Products in China

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