Gentamicin fluoroimmunoassay kit

Brown, D L; Birks, S. F.; Curtis, Gordon D W; Perks, E M

doi:10.1093/jac/7.2.205

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1998

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“…Over the years, numerous penicillin derivatives have been prepared and examined for antibacterial activity. Additionally, a variety of new β-lactam-containing ring systems isolated from natural sources or from synthetic laboratories have been reported, including the penems, carbapenems, cephalosporins, clavulanic acids, oxapenams, oxacephams, and monocyclic, spirocyclic, and multicyclic 18 analogues. The most common classes of β-lactam antibiotics are illustrated below.…”

Section: Introductionmentioning

confidence: 99%

Studies on Nonconventionally Fused Bicyclic β-Lactams

et al. 1998

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Studies on Nonconventionally Fused Bicyclic β-Lactams.-A number of structurally novel [3.2.0]bicyclic β-lactam ring systems such as (IV), (IX), and (XIV) that have the lactam functionality arranged in alternative orientations within the four-membered ring are prepared. Semiempirical calculations indicate that the thermodynamic stabilities of the alternative isomeric ring systems are similar to that of the classical structure. The derivatives (Xb) and (XVI) show weak activity against Staphylococcus aureus or Vibrio cholerae.

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