Gentamicin and Other Antibiotic Toxicitiy

Thomas, T.; Galiani, David L.; Brod, Roy D.

doi:10.1016/s0896-1549(05)70261-3

Cited by 26 publications

(19 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 Analysis of the effects of intraocular administration of different antibiotics has also shown a range of ocular toxicity. 7 In our patient, the dew droplets noted on the peripheral iris and angle may have been a precursor to trabecular meshwork obstruction, although there was no significant uveitis or glaucoma detectable during the period of monitoring before explantation. It is possible that the droplet adherent to the IOL was noted 2 months postoperatively because of the time required for coalescence of these smaller dew droplets, or possibly due to repositioning of the droplet from a nonvisible location behind the iris to a location more visible closer to the visual axis.…”

Section: Discussionmentioning

confidence: 53%

Surgical removal of intraocular antibiotic ointment after routine cataract phacoemulsification

Wong¹,

Bank²

2006

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

We report surgical removal of a droplet of intraocular chloramphenicol ointment in a 70-year-old man who had routine small-incision phacoemulsification. A spherical droplet of ointment adherent to the intraocular lens was noted 2 months postoperatively. The source was considered to be the immediate postoperative conjunctival fornix chloramphenicol ointment. Gonioscopy revealed tiny droplets adherent to the peripheral iris and angle. The droplet was surgically explanted using a minimally traumatic technique with a lens glide and ophthalmic viscosurgical device through an enlarged clear corneal incision and sent intact for laboratory biochemical analysis. The patient maintained good vision without evidence of uveitis or secondary glaucoma at 1 year of follow-up. This uncommon case also raises issues about the need for immediate postoperative antibiotic ointment for endophthalmitis prophylaxis and phacoemulsification thermal wound effects on the integrity of self-sealing clear corneal incisions.

show abstract

Section: Discussionmentioning

confidence: 53%

Surgical removal of intraocular antibiotic ointment after routine cataract phacoemulsification

Wong¹,

Bank²

2006

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

show abstract

“…Similar cases of retinal infarction with macular cherry red spot have been reported following intraocular injection of gentamycin and other amino glycosides aimed at preventing post-operative endophthalmitis. Many of such cases have had to do with either intravitreal injection or direct injection near areas of sclera thinning or laceration (Thomas et al, 2001). This scenario is unlikely as gentamycin was not used in this case.…”

Section: Discussionmentioning

confidence: 99%

Central Retinal Arterial Occlusion (CRAO) after Phacoemulsification-A Rare Complication

Lamichhane

Gautam

2013

Nep J Oph

View full text Add to dashboard Cite

Background: While peribulbar anesthesia is generally safe, a remote risk of retinal vascular accident exists and its routine use should be done with caution. Objective: To report a case of central retinal artery occlusion (CRAO) that occurred within 24 hours of routine uneventful phacoemulsification cataract surgery using peribulbar anesthesia. We share our experience of a 45-year old man who underwent uneventful clear corneal temporal incision phacoemulsification cataract surgery using peribulbar lignocain injection with adrenaline. Case: A Patient who underwent routine phacoemulsification surgery of left eye for posterior sub-capsular cataract under peribulbar anesthesia developed central retinal artery occlusion in the immediate post-operative period. The surgery was uneventful. Conclusion: Central retinal artery occlusion is a rare but dreadful complication seen after uneventful phacoemulsification and the cause is mainly due to anesthesia related.

show abstract

“…Digoxin is also known to inhibit this exchanger in photoreceptor cells and administration of digoxin is associated with altered colour perception and blurred vision (Lawrenson, et al, 2002). The aminoglycoside antibiotic, gentamicin, is linked with conjunctivitis, in which accumulated drug irritates the conjunctival epithelial cells causing ocular burning (Thomas, Galiani, & Brod, 2001). Retinal detachment and lamellar liposomal inclusions have been identified in animals receiving gentamicin treatment because of abnormal deposition of lysosomal cells in the retinal pigment epithelium (RPE) (D'Amico, et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response

Deeti

O’Farrell

Kennedy

2014

Journal of Pharmacological and Toxicological Methods

View full text Add to dashboard Cite

Publication informationJournal of Pharmacological and Toxicological Methods, 69 (1): 1-8 Publisher ElsevierItem record/more information http://hdl.handle.net/10197/7931 Publisher's statementThis is the author's version of a work that was accepted for publication in Journal of Pharmacological and Toxicological Methods. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Pharmacological and Toxicological Methods (VOL 69, ISSUE 1, ((2014) Abstract Introduction: Many prescribed drugs can adversely affect the eye by causing damage to the function of visual pathways or toxicity to the retina. Zebrafish have the potential to efficiently predict drugs with adverse ocular effects at pre-clinical stages of development. In this study, we explore the potential of using a semi-automated visual behaviour assay to predict druginduced ocular toxicity in wild-type zebrafish larvae. Methods: 3 dpf larvae were treated with six known oculotoxic drugs and five control drugs in embryo medium containing 0.1% DMSO. After 48 hours, larvae were assessed using the visualmotor response (VMR), an assay which quantifies locomotor responses to light changes; the optokinetic response (OKR), a behavioural assay that quantifies saccadic eye responses to rotating stimuli; and the touch response, a locomotor response to tactile stimuli. Results: 9 of 10 negative control drugs had no effect on zebrafish visual behaviour. 5 of the 6 known oculotoxic drugs (digoxin, gentamicin, ibuprofen, minoxidil and quinine) showed adverse effects on zebrafish visual behaviour assessed by OKR or the more automated VMR. No gross morphological changes were observed in treated larvae. The general locomotor activity of treated larvae, tested using the touch response assay, showed no differences with respect to controls. Overall the VMR assay had a sensitivity of 83%, a specificity of 100% and a positive predictive value of 100%. Discussion: This study confirms the suitability of the VMR assay as an efficient and predictive pre-clinical approach to evaluate adverse ocular effects of drugs on visual function in vivo.

show abstract

Gentamicin and Other Antibiotic Toxicitiy

Cited by 26 publications

References 48 publications

Surgical removal of intraocular antibiotic ointment after routine cataract phacoemulsification

Surgical removal of intraocular antibiotic ointment after routine cataract phacoemulsification

Central Retinal Arterial Occlusion (CRAO) after Phacoemulsification-A Rare Complication

Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response

Contact Info

Product

Resources

About