Genotyping of theCYP1A1 andGSTM1 genes in esophageal carcinoma patients with special reference to smoking

Nimura, Yuji; Yokoyama, Shiro; Fujimori, Minoru; Aoki, Takahira; Adachi, Wataru; Nasu, Tamie; He, Min; Ping, Yu-Min; Iida, Futoshi

doi:10.1002/(sici)1097-0142(19970901)80:5<852::aid-cncr4>3.0.co;2-n

Cited by 67 publications

(26 citation statements)

References 19 publications

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“…However, their small case popula- CYP1A1 and oesophageal cancer M-T Wu et al tion (less than 100 oesophageal cancer cases were investigated) may not be sufficient to make a scientific determination regarding genotype significance. Although Roth et al (2000) found no significant effect of CYP1A1 exon 7 polymorphisms on either the 56 individuals with mild or moderate squamous dysplasia or the 56 control cases from a high oesophageal cancer risk region with an ethnic Chinese population, Nimura et al (1997) found subjects in China with heavy smoking habits had a three times higher frequency of the CYP1A1 Val/Val variant. Recently, Wang et al (2002) also found that individuals with the CYP1A1 Val/Val genotype had a higher risk of developing oesophageal cancer than those with the Ile/Ile (OR=2.48, 95% CI=1.12 -5.54).…”

Section: Discussionmentioning

confidence: 94%

“…As reported by Bartsch et al (2000), no association was identified between CYP1A1 MspI and exon 7 polymorphisms and oesophageal cancer risk in a series of studies done on populations of Caucasians and Japanese (Lucas et al, 1996;Hori et al, 1997;Morita et al, 1997;van Lieshout et al, 1999). However, Nimura et al (1997) studied 89 oesophageal carcinoma patients and 137 cancer-free control patients in an ethnically Chinese population and reported that heavy smokers with Val/Val genotypes of CYP1A1 exon 7 had a three-fold risk of developing oesophageal cancer as compared to those with Ile/Ile genotypes. A subsequent study by Roth et al (2000) did not find any significant effect of CYP1A1 exon 7 polymorphisms in 56 individuals with mild or moderate squamous dysplasia and 56 control individuals (a relatively small sample size) from Linxian, a region of high oesophageal cancer risk in China.…”

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confidence: 89%

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Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan

Lee

et al. 2002

Br J Cancer

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Several in vitro studies have demonstrated that genetic polymorphisms result in functionally significant changes in cytochrome p4501A1 (either CYP1A1 MspI or exon 7) but the few epidemiologic studies of these polymorphisms in oesophageal squamous-cell carcinoma have been inconclusive. These inconclusive results motivated us to further examine the relationship between CYP1A1 MspI and exon 7 polymorphisms and risk of oesophageal cancer. In total, 146 cases of oesophageal squamous-cell-carcinoma and 324 control cases (a total of 470 cases) were genotyped from records at three Taiwan hospitals. No significant association was noted for the CYP1A1 MspI polymorphism variable between carcinoma and control cases. In contrast, the frequency of Ile/Ile, Ile/Val, and Val/Val in exon 7 was 68 (46.6%), 62 (42.5%), and 16 (11.0%) in carcinoma cases and 179 (55.3%), 127 (39.2%), and 18 (5.6%) in control cases, respectively. After factoring out other potential contributing factors, patients with Val/Val showed a 2.48 (95% CT=1.15 -5.34) greater risk of developing oesophageal cancer than those with Ile/Ile. A slightly (albeit not significantly) greater risk was identified in subjects with Ile/Val (OR=1.34; 95% CI=0.86 -2.07). These findings suggest that an exon 7 polymorphism, not a MspI polymorphism, in CYP1A1 may be pivotal in the development of oesophageal cancer.

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Section: Discussionmentioning

confidence: 94%

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confidence: 89%

Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan

Lee

et al. 2002

Br J Cancer

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“…Esophageal cancer patients in China who were heavy smokers had a threefold higher frequency of the CYP1A1 Val-Val variant. The risk was further increased in patients with the combination of CYP1A1 Val-Val and GSTM1 0/0 genotypes (Nimura et al, 1997). In bladder cancer, two studies of Japanese and Caucasians showed no significant associations (Katoh et al, 1995;Brockmo¨ller et al, 1996).…”

Section: Carcinogen Metabolismmentioning

confidence: 90%

“…In a review of 24 published papers on squamous cell carcinoma of the head and neck, the results of these studies are inconsistent, with some reporting weak-to-moderate associations and others finding no elevation in risk for the main effect of the gene (Geisler and Olshan, 2001). Several studies in Asia reported the positive association between GSTM1 polymorphism and esophageal cancer (Nimura et al, 1997;Gao et al, 2002;Wang et al, 2004).…”

Section: Carcinogen Metabolismmentioning

confidence: 99%

Genetic susceptibility to tobacco-related cancer

et al. 2004

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Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a small fraction of individuals with tobacco exposure develop cancer. The underlying hypothesis is that genetic factors may render certain smokers more susceptible to cancer than others. Genetic alterations in critical regulatory pathways may predispose cells to carcinogenesis. These pathways include regulation of xenobiotic metabolism; control of genomic stability, including DNA repair mechanisms, cell-cycle checkpoints, apoptosis and telomere length; and control of microenvironmental factors, such as matrix metalloproteinases, inflammation and growth factors. In addition, epigenetic events, such as promoter hypermethylation and loss of imprinting, are also involved in carcinogenesis. In this review, we will summarize recent advances in genetic susceptibility to tobacco-related cancer. Emphasizing on risk assessment, we will describe how genetic variations in the above-mentioned genetic pathways modify the tobacco-related cancer risk. In addition, we will discuss how genetic variations may assist in predicting clinical outcome, such as the natural history of cancer and treatment response. The measurements of genetic susceptibility by both genotypic and phenotypic assays are covered in the text. Finally, we present a number of current concerns that need to be addressed as the exciting field of molecular cancer epidemiology advances rapidly.

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“…No association was identified between CYP1A1 MspI and Ile/ Val polymorphisms with esophageal cancer risk in a series of studies done on populations of Caucasians and Japanese (Lucas et al, 1996;Hori et al, 1997;Morita et al, 1997;van Lieshout et al, 1999). However, Nimura et al (1997) reported that heavy smokers with Val/Val genotype of CYP1A1 Ile/Val had a three-fold risk of developing esophageal cancer as compared to those with Ile/Ile genotype in a case-control study in Chinese population. Roth et al (2000) carried out a study in Linxian, a region of high esophageal cancer risk in China, and did not find any significant effect between CYP1A1 Ile/Val polymorphism and esophageal cancer.…”

Section: Introductionmentioning

confidence: 98%

CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

Yun

Wang

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The purpose of this study was to evaluate the associations of CYP1A1 genetic polymorphisms with the risk of developing esophageal cancer (EC). A case-control study was carried out in a Chinese population in which 157 hospital based EC cases and 157 population based healthy controls with 1:1 match by age and sex were included. PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect genotypes in case and control groups.

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Genotyping of theCYP1A1 andGSTM1 genes in esophageal carcinoma patients with special reference to smoking

Cited by 67 publications

References 19 publications

Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan

Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan

Genetic susceptibility to tobacco-related cancer

CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

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