Genotyping of<i> IL-4</i> −590 (C&gt;T) Gene in Iraqi Asthma Patients

Hussein, Ihsan A.; Jaber, Saddam H

doi:10.1155/2017/5806236

Cited by 14 publications

(14 citation statements)

References 19 publications

(21 reference statements)

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“…In the current meta-analysis, 818 asthma patients and 831 healthy individuals participated in these 8 independent case-control studies [ 18 , 19 , 21 – 25 ]. In Table 1 , the genotype distribution and detailed characteristics of the selected studies about the relationship between the polymorphism of IL-4-590C > T and the susceptibility to asthma are displayed.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the polymorphism of IL-4-590C > T gene in the risk of asthma has not been clearly concluded. The study of Hussein et al [ 21 ] showed that the increased susceptibility to asthma was associated with the C allele and CC genotype of IL-4-590C > T gene polymorphism, which was considered to be the etiological part of asthma. However, it was found that the higher the percentage of T allele in the control group, the lower the susceptibility to asthma [ 18 , 19 , 21 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Association between Interleukin-4-590C>T Polymorphism and the Susceptibility to Asthma: A Meta-Analysis of Case-Control Study

Liu

Yin

Luo

et al. 2022

Journal of Healthcare Engineering

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This study was aimed to investigate the relationship between the interleukin-4-590C > T gene polymorphism and the susceptibility to asthma by meta-analysis. To explore the underlying relationship between the polymorphism of IL-4-590C > T and the susceptibility to asthma, this study systematically retrieved the literature including cohort studies and case-control studies published before June 2019 in PubMed, Embase, and Cochrane Library. Data on the odds ratio (OR) and 95% confidence interval (CI) of the literature were included in the relative studies. Subsequently, the included data were weighted by an inverse variance and then analyzed by the fixed or random effects model. Overall, 818 asthma patients and 831 healthy individuals participated in the 8 independent case-control studies in the current meta-analysis. There was no correlation between IL-4-590C > T TT genotype and the increased susceptibility to asthma (dominant model: OR = 1.31, 95% CI = 0.68–2.53). Subgroup analysis by ethnicity showed no significant results in the Asians (OR = 1.28, 95% CI = 0.24–6.80); however, IL-4-590C > T TT genotype significantly elevated the susceptibility to asthma in the Caucasians (OR = 1.43, 95%CI = 1.03–1.98). Meanwhile, subgroup analysis was performed by source of control. A statistically significant result was found in the population-based control group (OR = 1.33, 95% CI = 1.01–1.76), but not in the hospital-based control group (OR = 1.22, 95% CI = 0.27–5.46). The results demonstrated that IL-4-590C > T TT genotype could significantly enhance the susceptibility to asthma in Caucasians without increasing that in Asian populations. However, it still required a large sample of high-quality studies in multicentral hospital to further confirm its reliability.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between Interleukin-4-590C>T Polymorphism and the Susceptibility to Asthma: A Meta-Analysis of Case-Control Study

Liu

Yin

Luo

et al. 2022

Journal of Healthcare Engineering

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“…In the context of asthma, the identification of susceptible genes that are involved in asthma pathogenesis and treatment response is the first step towards developing personalized medicine 10,11. Genome-wide association studies, candidate-gene linkage studies, and positional cloning have already discovered a large number of genetic variants in multiple genes that have been associated with altered therapeutic response to asthma medications and hence affect the level of asthma control 5,10,11. The ADRB2 gene is one of the most widely studied asthma susceptible genes 12,13.…”

Section: Introductionmentioning

confidence: 99%

<p>Association of genetic variants with level of asthma control in the Arab population</p>

Almomani¹,

AL-Eitan²,

Al‐Sawalha³

et al. 2019

JAA

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BackgroundRates of asthma in Jordan have been doubled in the past decade, but this increased prevalence was not met with improved asthma control protocols. The aim of the present study was to assess whether there was any significant association between the level of asthma control and certain single-nucleotide polymorphisms (SNPs) in five genes: (ADRB2; rs1042713 and rs1042714), (CRHR1; rs1876828, rs242939, and rs242941), (STIP1; rs2236647), (ADH5, rs1154400), and (ARG1; rs2781659). These SNPs were selected based on their involvement in enzymes and receptors that are related to asthma pathways and subsequent response to medication and based on a high degree of linkage disequilibrium.Patients and methodsA cross-sectional genetic association study was conducted from June 2016 to June 2017 in the two major hospitals in Jordan. The present study involved sampling from adult asthmatic patients of Arab descent who were selected from two phenotypic groups, ie, controlled and uncontrolled asthma. The blood samples and medical data were collected from the participants. DNA samples were extracted, quantified, and genotyped according to standard operating procedure. Allelic and haplotypic analyses were performed using the Haploview®.ResultsA total of 245 Arab asthmatic patients were enrolled in this study. Genotyping analysis revealed that the two SNPs (rs1042713 and rs1042714) in ADRB2 gene, along with their related haplotypes, were nominally significantly associated with asthma control in the Jordanian population. The A-allele of rs1042713 and the C-allele of rs1042714 were more common in the uncontrolled asthma group than in the controlled asthma group (P=0.048 and P=0.017, respectively).ConclusionThis was the first study that identified the nominal significant association between the level of asthma control and genetic variants in ADRB2 gene in Arab population. Further studies in other Arab region with larger sample size are recommended to confirm the relationship.

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“…One of the core factors of asthma attack is the high activation of Th2, and IL-4 plays an important role as the key component of Th2 activation. The function of IL-4 is related to multiple factors, among which the -589C/T polymorphism has been widely studied (24).…”

Section: Mechanisms Of Asthmamentioning

confidence: 99%

Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis

Zhu¹,

Liu²,

Wang³

et al. 2021

Transl Pediatr

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Background: To identify the association between polymorphisms in the interleukin 4 (IL-4) promoter -589C/T gene and the risk of asthma.Methods: The databases of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Chongqing VIP (CQVIP), and Chinese Biomedical Literature (CBM) were searched and appropriate journal articles on the association between polymorphisms in the IL-4 promoter -589C/T gene and the risk of asthma were retrieved from establishment of the database to April 2021. All relevant randomized controlled trials (RCTs) were included, to the exclusion of duplicate publications, studies with no whole composition, imperfect information or inability to extract data, animal experiments and reviews, and systematic reviews. The software Review manager 5.3 was used to analyze the data.Results: Literature search led to retrieving of 16 publications containing 3181 cases and 3786 controls.The results show that CT, CC, and T gene polymorphisms were risk factors for asthma [odds ratio (OR) =1.05, 95% confidence interval (CI): 0.89-1.24; OR =1.04, 95% CI: 0.85-1.27; OR =1.98, 95% CI: 1.54-2.53]. Ethnic subgroup analysis showed that genotype CT was associated with the risk of asthma in the Asian population (OR =1.75, 95% CI: 1.01-3.05).Discussion: Through the study of IL-4 (C-590T) gene polymorphism, it was found that CT, TT, and T gene polymorphism were risk factors for asthma, and the results suggested that this locus polymorphism was related to the risk of asthma. The results of subgroup analysis showed that CC and T gene polymorphisms were risk factors for asthma. Thus, IL-4(C-590T) may be the susceptibility gene of asthma.

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Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients

Cited by 14 publications

References 19 publications

Association between Interleukin-4-590C>T Polymorphism and the Susceptibility to Asthma: A Meta-Analysis of Case-Control Study

Association between Interleukin-4-590C>T Polymorphism and the Susceptibility to Asthma: A Meta-Analysis of Case-Control Study

<p>Association of genetic variants with level of asthma control in the Arab population</p>

Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis

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