&lt;p&gt;Association of genetic variants with level of asthma control in the Arab population&lt;/p&gt;

Almomani, Basima A.; AL-Eitan, Laith N.; Al‐Sawalha, Nour A.; Samrah, Shaher; Al-Quasmi, Mohammed N

doi:10.2147/jaa.s186252

Cited by 11 publications

(11 citation statements)

References 40 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An association of the rs2781666*T allele and CT haplotype (rs60389358, rs2781666) of the ARG1 gene with asthma and a considerably higher level of serum arginase was established in asthma patients from India (Donthi et al, 2018). On the contrary, some studies did not detect a significant association of ARG1 gene polymorphisms with the efficacy of asthma therapies (Almomani et al, 2019;Scaparrotta et al, 2019). Together, this results and literature data confirm that ARG1 gene allelic variants can contribute to asthma pathogenesis and the effectiveness of disease therapy.…”

Section: Discussionsupporting

confidence: 55%

The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma

et al. 2020

View full text Add to dashboard Cite

Asthma is a common severe disease of the respiratory tract, it leads to a significant impairment in the quality of a patient’s life unless effectively treated. Uncontrolled asthma symptoms are a cause of disease progression and development, they lead to an increase in the patient’s disability. The sensitivity to asthma therapy largely depends on the interaction of genetic and epigenetic factors, which account for about 50–60 % of variability of therapeutic response. Beta-2-agonists are some of the major class of bronchodilators used for asthma management. According to published data, allelic variants of the arginase ARG1 and ARG2 genes are associated with a risk of asthma development, spirometry measures and efficacy of bronchodilator therapy. High arginase activity results in a low level of plasma L-arginine and in a decrease in nitric oxide, and, as a result, in an increase in airway inflammation and remodeling. Arginase genetic polymorphisms (rs2781667 of the ARG1 gene, rs17249437, rs3742879, rs7140310 of the ARG2 gene) were studied in 236 children with asthma and 194 unrelated healthy individuals of Russian, Tatar and Bashkir ethnicity from the Republic of Bashkortostan. Association analysis of the studied polymorphisms with asthma development and course, the sensitivity to therapy in patients was carried out. It was found that the rs2781667*C allele of the ARG1 gene is a marker of an increased risk of asthma in Tatars. In Russians, the association of rs17249437*TT and rs3742879*GG genotypes of the ARG2 gene with a decrease in spirometry measures (FEV1, MEF25) was established. In Russians and Tatars receiving glucocorticoid monotherapy or combination therapy, the association of the rs17249437*T allele and rs17249437*TT genotype of the ARG2 gene with a partially controlled and uncontrolled course of asthma was shown.

show abstract

Section: Discussionsupporting

confidence: 55%

The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Moreover, only 30% of the adult patients that took part in a recent Jordanian study were reported to have achieved asthma control [20]. A study from northern of Jordan showed that smoking is the main cause of poor asthma control in adolescent[4] and two studies from Jordan attributed poor control to non-adherence or improper use of inhalers [21, 22]; moreover one study showed a significant association between the level of asthma control and genetic in Arab population [23]. However, this issue is rarely investigated in the south of Jordan and the burden of uncontrolled asthma on patients is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Asthma Control and Its Predictive Factors in Adult Asthma Patients

et al. 2019

View full text Add to dashboard Cite

BackgroundAsthma is a highly prevalent condition that remains difficult to control, as its associated factors remain poorly understood. Thus, the primary aim of the present investigation was to determine the prevalence of uncontrolled asthma in hospital units in south Jordan and to evaluate the risk factors that may contribute to uncontrolled asthma.MethodsThis was a cross-sectional study involving 93 patients aged 40.5 ± 13.6 years that met the criteria of the Global Initiative for Asthma (GINA). Relevant patient data were collected via a questionnaire and through a review of medical records. The questionnaire comprised of sections pertaining to sociodemographic and clinical characteristics, as well as pharmacological asthma treatment, asthma severity and asthma control. Asthma severity was determined in line with the GINA guidelines, whereby the patients were classified into four groups (intermittent, mild persistent, moderate persistent or severe persistent). Moreover, based on the findings yielded by the asthma control questionnaire (ACQ), patients were divided into three levels, whereby those diagnosed with partly controlled and uncontrolled asthma were combined into one group, denoted as “poorly controlled asthma”, with “uncontrolled asthma” and “controlled asthma” as the remaining two groups. Atopy was defined as one or more positive reactions (A/H ratio > 1) on a skin prick test.ResultsAsthma control was achieved in 45.2% of the sample. Moreover, older age, severe asthma according to the GINA guidelines, longer duration of asthma, atopy, being on treatment for asthma and history of allergic rhinitis were identified as the main risk factors contributing to poorly controlled asthma. Multivariate analyses, however, revealed that only atopy to two or more allergens and having severe asthmatic attacks were statistically significantly associated with poorly controlled asthma, for which the odds ratio Mantel-Haenszel (ORMH) of 17.2 and 2.2 was obtained, respectively.ConclusionOur findings indicate that severe asthma and atopy to two or more allergens are the main risk factors for uncontrolled asthma. However, further studies with larger sample sizes are needed to confirm these results.

show abstract

“…No relationship was revealed between the increased risk of uncontrolled asthma and the Arg16 allele in asthma patients using ICS and/or LABA. Additionally, Almomani et al reported that the Arg16 allele of Arg16Gly polymorphism is more common among patients with uncontrolled asthma in the Arab population. The influence of Arg16Gly polymorphism on asthma control could be related to impaired ADRB2 function because the presence of arginine instead of glycine in its structure in the 16th amino acid position.…”

Section: Discussionmentioning

confidence: 99%

“…A detailed characterisation of asthma patients contributes to the investigation of the disease pathogenesis, selection of the most optimal therapeutic approaches, monitoring the treatment effectiveness and assessing the risk of disease progression . Arg16Gly and Gln27Glu ADRB2 gene polymorphisms showed association with intermediate asthma phenotypes: nocturnal, severe, uncontrolled, therapy‐resistant and atopic . The most frequent asthma endotype is type 2 asthma .…”

Section: Discussionmentioning

confidence: 99%

An investigation of the association between ADRB2 gene polymorphisms and asthma in Kazakh population

Akparova

Aripova

Abishev³

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

Introduction: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat the obstructive lung diseases. Objectives: This study aimed to investigate the possible association of the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene with asthma and its endophenotypes in the Kazakh population. Methods: A total of 70 asthmatic patients and 80 healthy controls were genotyped for Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene by using quantitative real-time polymerase chain reaction. Statistical analysis was performed with the Graph Pad InStat 7 Software. Results: No associations between the asthma patients and healthy individuals were found when the allele and genotype distribution of Arg16Gly and Gln27Glu single nucleotide polymorphisms were compared. Analysis of the haplotype frequencies showed statistically significant differences between patients with asthma and controls for Arg16Gly/Gln27Gln and Arg16Gly/Gln27Glu haplotypes (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 0.87-5.16 and OR = 2.25, 95% CI = 0.89-5.67 respectively). The Arg16 allele and Arg16Arg genotype frequencies were higher in patients with uncontrolled asthma than in controls (χ 2 = 5.17, df = 1, P = 0.02 and χ 2 = 5.36, df = 1, P = 0.02 respectively). Conclusion:The results of this study support the possible involvement of Arg16Gly polymorphism in the development of uncontrolled asthma, and indicate that Arg16Gly/Gln27Gln and Arg16Gly/Gln27Glu haplotypes are more common in asthma patients in the Kazakh population. K E Y W O R D Sasthma, beta-2-adrenergic receptor, Kazakhstan, single nucleotide polymorphisms

show abstract

<p>Association of genetic variants with level of asthma control in the Arab population</p>

Cited by 11 publications

References 40 publications

The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma

The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma

Asthma Control and Its Predictive Factors in Adult Asthma Patients

An investigation of the association between ADRB2 gene polymorphisms and asthma in Kazakh population

Contact Info

Product

Resources

About