Genotypic characterization of Chilean llama (Lama glama) and alpaca (Vicugna pacos) pestivirus isolates

Aguirre, Isidora; Fuentes, Rosa; Celedón, M.O.

doi:10.1016/j.vetmic.2013.11.031

Cited by 5 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, these isolates were grouped as BVDV-1e when the N pro and E2 coding regions were studied [45,46]. Furthermore, Aguirre et al [15] described BVDV isolates from llama and alpaca as BVDV-1j using 5′UTR sequences, but based on analysis of E2 coding sequences the same isolates were classified as BVDV-1e. The “So CP/75” isolate was first reported to represent a unique virus belonging to BVDV-1 [38,45] and later classified in the BVDV-1n group by the same authors with another isolate, “Shitara/02/06” [106].…”

Section: Bvdv Variabilitymentioning

confidence: 99%

“…The segregation of BVDV isolates into subgenotypes is shown in Table 1, Table 2, Table 3, Table 4 and Table 5 for the individual continents. Viruses from the established subgenotypes have been detected not only in cattle, but also in pigs and a wide range of ruminant hosts, including sheep, goat, yak, buffalo, llama, alpaca, camel, deer, and bongo [15,16,17,35,42,47,67,80,86,88,103,172]. …”

Section: Global Distribution Of Bvdv Subgenotypesmentioning

confidence: 99%

“…Although pestiviruses were initially designated according to their host of origin, infections with BVDV have been detected in diverse domestic and wildlife animal species, including cattle, sheep, goat, pig, deer, buffalo, bison, and alpaca [15,16,17]. In addition to its respiratory, gastroenteric and reproductive clinical consequences, intrauterine infection of the fetus with BVDV can result in the birth of immunotolerant, persistently infected (PI) animals.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Yeşilbağ

Alpay

Becher

2017

Viruses

192

250

View full text Add to dashboard Cite

Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and distributed on all of the continents. BVDV-1 can be segregated into at least twenty-one subgenotypes (1a–1u), while four subgenotypes have been described for BVDV-2 (2a–2d). With respect to published sequences, the number of virus isolates described for BVDV-1 (88.2%) is considerably higher than for BVDV-2 (11.8%). The most frequently-reported BVDV-1 subgenotype are 1b, followed by 1a and 1c. The highest number of various BVDV subgenotypes has been documented in European countries, indicating greater genetic diversity of the virus on this continent. Current segregation of BVDV field isolates and the designation of subgenotypes are not harmonized. While the species BVDV-1 and BVDV-2 can be clearly differentiated independently from the portion of the genome being compared, analysis of different genomic regions can result in inconsistent assignment of some BVDV isolates to defined subgenotypes. To avoid non-conformities the authors recommend the development of a harmonized system for subdivision of BVDV isolates into defined subgenotypes.

show abstract

Section: Bvdv Variabilitymentioning

confidence: 99%

Section: Global Distribution Of Bvdv Subgenotypesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Yeşilbağ

Alpay

Becher

2017

Viruses

192

250

View full text Add to dashboard Cite

show abstract

“…Bovine viral diarrhea virus is an important pathogen of cattle worldwide, causing a variety of different symptoms and clinical diseases which can lead to major economic losses. In recent years, epidemiological studies have suggested that BVDV has become infectious to a growing number of animal species beyond cattle, including pigs and ruminants such as sheep, goats, yak, buffalo, llama, alpaca, camel and deer [4,21,22]. The growing number of hosts that BVDV is capable of infecting presents a major challenge to BVDV eradication efforts.…”

Section: Discussionmentioning

confidence: 99%

Characterization and evolutionary analyses of Pestivirus A isolated from cattle in China

Liu

Villanova

Leal

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Bovine viral diarrhea virus (BVDV) is a single stranded RNA virus with worldwide distribution that belongs to the genus Pestivirus, family Flaviviridae. Infection of cattle with BVDV causes a range of clinical syndromes and can result in major economic losses. Here, we reported two BVDV isolates obtained from serum collected from cattle in Shandong province, China and commercial fetal bovine serum. Results The two BVDV isolates, named BVDV BJ-2013 and BVDV BJ-2016, were both the members of Pestivirus A, belonged to genotype 1a and 1b, respectively. BVDV BJ-2013 was an cytopathogenic biotype virus, meanwhile BVDV BJ-2016 was non-cytopathogenic biotype virus. The two isolates, both with 45.3% GC content, were 12,305 nt (BVDV BJ-2013) and12,273 nt (BVDV BJ-2016) in length. Phylogenetic analyses showed that BVDV BJ-2016 was genotype 1B of Pestvirus A and closely related to isolates from South Korea (JQ418634) and the US (JN380088). Simultaneously, BVDV BJ-2013 was genotype 1A of Pestivirus A and related to isolates from the USA (AF091605) and Germany (AF041040). Recombination analysis showed that BVDV isolate (KJ541471) was a mosaic of sequences derived from two isolates of the genotype 1A. Evolutionary analysis suggested that genotype 1A and 1B had similar relative rates and the dN/dS ratios. Comparison analysis of amino acid sequence indicated that there were 12 amino acids (EGNWLVNADRLM) insertion in NS2 of BVDV BJ-2013. Conclusion: In present study, two BVDV isolates were isolated and identified. Phylogenetic analyses and evolutionary analysis suggested that BVDV strains isolated from different regions showed close evolutionary relationships. It also reminded us again that the risk of trans-regional transmission of BVDV and BVDV contamination in commercial fetal bovine serum were what we must not neglect.

show abstract

“…The BVD was first observed in 1946 in New York USA (4) and characterized with diarrhea, pyrexia, gastrointestinal erosions, leukopenia, anorexia, depression, and hemorrhages (5). The endemic infections of BVDV have been reported in cattle populations all over the world (6)(7)(8)(9)(10)(11), where a variety of other domestic and wildlife animal species got involved as well, including buffalo, sheep, pigs, goats, deer, alpacas, and bison (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Bovine viral diarrhea virus in China: A comparative genomic and phylogenetic analysis with complete genome sequences

et al. 2022

View full text Add to dashboard Cite

Bovine viral diarrhea virus (BVDV), causing bovine viral diarrhea (BVD) in cattle, is one of the highly contagious and devastating diseases of cattle. Since 1980, BVDV has been identified all-over China in a variety of animal species including cattle, camels, yaks, sheep, water buffalo, goats, Sika deer and pigs. In this study, 31 BVDV complete genomes reported in China (from 2004 to 2020) with other 112 genomes reported around the world were comparatively analyzed. Phylogenetic analysis shows that BVDV genomes reported worldwide clustered in three major clades i.e., BVDV-1, BVDV-2, and BVDV-3. The BVDV-1 is genetically the most diverged genotype and phylogenetically classified into 7 sub-clades in our study based on full-length genomes. The China BVDV genomes fall into all three major clades, e.g., BVDV-1, BVDV-2 and BVDV-3. China BVDV-1 clustered into five sub-clades, e.g., 1, 2, 3, 6 and 7, where sub-clade 7 clustered as a separate sub-clade. Full-length genome recombination analysis reveals that the BVDV-1 reported in China appears to be mainly involved in recombination events. In addition, comparative analysis of E2 proteins between BVDV-1, BVDV-2, and BVDV-3 reveals that the amino acid variations could affect 12 potential linear B cell epitopes, demonstrating a dramatic antigen drift in the E2 protein. These results provide a thorough view of the information about the genetic and antigenic diversity of BVDVs circulating in China and therefore could benefit the development of suitable strategies for disease control.

show abstract

Genotypic characterization of Chilean llama (Lama glama) and alpaca (Vicugna pacos) pestivirus isolates

Cited by 5 publications

References 38 publications

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Characterization and evolutionary analyses of Pestivirus A isolated from cattle in China

Bovine viral diarrhea virus in China: A comparative genomic and phylogenetic analysis with complete genome sequences

Contact Info

Product

Resources

About