Genotypes of GSTM1 and GSTT1: Useful determinants for clinical outcome of bladder cancer in Pakistani population

Malik, Saima Shakil; Nawaz, Gul; Masood, Nosheen

doi:10.1016/j.ejmhg.2016.03.001

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…A similar observation was made by Burger et al [8]. Several previous studies in the world demonstrated the increased risk of bladder cancer in smokers [5,7,16,17].…”

Section: Discussionsupporting

confidence: 70%

“…This finding is consistent with combined results of 26 studies represented in the meta-analysis of Zhang et al [26], including 5029 bladder cancer cases and 6680 controls. Other more recent studies carried out in India and Pakistan have given the same result [16,27]. Among all studied ethnic groups, the association between GSTM1 null genotype and risk of bladder cancer was observed in Asians and Caucasians [26].…”

Section: Discussionsupporting

confidence: 61%

“…Positive association of GSTM1 and GSTT1 deletion polymorphism and bladder carcinoma was found among many populations [16]. However, data related to a genetic status of GSTM1 and GSTT1 and their association to bladder cancer is not available in Algerian population.…”

Section: Hireche Et Almentioning

confidence: 99%

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Polymorphic Deletions of Glutathione S-Transferases M1, T1 and Bladder Cancer Risk in Algerian Population

Hireche

Kherouatou

Ribouh

et al. 2018

Asian J Pharm Clin Res

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Objective: Glutathione S-transferase mu 1 (GSTM1) and GST theta 1 (GSTT1) genes are two xenobiotic metabolizing genes in Phase II of the detoxification process. The polymorphisms of GSTM1, GSTT1 genes, and smoking are involved in many cancers such as bladder cancer. Our aim was to assess the role of smoking status and GSTM1 and GSTT1 null genotypes in bladder cancer development in Algerian population. Methods:The current case-control study included 175 bladder cancer patients and 188 controls matched for age, gender, and ethnic origin. The GSTM1 and GSTT1 genotypes were determined by multiplex polymerase chain reaction using blood genomic DNA. Possible associations of stage and grade with the obtained genotypes were also tested.Results: A significant associations were observed between bladder cancer risk and tobacco smoke (p value: p=1.21E-08), GSTM1 null genotype (p=0.018), GSTT1 null genotype (p=0.009), and GSTM1/GSTT1-double null genotype (p=0.001). The combined effect of smoking and testing deletions increased the risk of bladder cancer and the most important risk was observed among smokers carrying GSTM1/GSTT1-double null genotype (p=1.09E-05). No significant association was shown between stage and grade of bladder cancer and the testing genotypes. Conclusion:This study indicated that smoking, GSTM1 null, GSTT1 null, and GSTM1/GSTT1-double null genotypes individually represent a risk factor for bladder cancer in Algerian population. The interaction smoking gene increased the risk considerably. In fact, it is suggested that patients with cigarette smoking habit and combined GSTM1 and T1 genes deletion might be at increased risk of bladder cancer.

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“…A similar observation was made by Burger et al [8]. Several previous studies in the world demonstrated the increased risk of bladder cancer in smokers [5,7,16,17].…”

Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 61%

See 1 more Smart Citation

Polymorphic Deletions of Glutathione S-Transferases M1, T1 and Bladder Cancer Risk in Algerian Population

Hireche

Kherouatou

Ribouh

et al. 2018

Asian J Pharm Clin Res

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“…This was an indication of increased oxidative stress which might have played a mediatory role in exerting the toxic effect at genetic level. [31] In addition, genotoxic effect was monitored as formation of micronucleus in rat bone marrow cells.…”

Section: Neurotoxic Effects Of Monosodium Glutamatementioning

confidence: 99%

Monosodium glutamate: Review on clinical reports

Kazmi

Fatima

Perveen

et al. 2017

International Journal of Food Properties

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103

111

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Monosodium glutamate is made up of nutritionally indispensable amino acids and used as flavour enhancer worldwide. Monosodium glutamate is believed to be associated with different health problems. This study is aimed to shed light on the available literature from last 25 years about different clinical trials which had been carried out on animal and human models regarding possible effects of monosodium glutamate. Google scholar, NCBI, PUBMED, EMBASE, Wangfang databases, and Web of Science databases were used to retrieve the available studies. Literature showed that monosodium glutamate was associated with adverse side-effects particularly in animals including induction of obesity, diabetes, hepatotoxic, neurotoxic and genotoxic effects. Different reports revealed increased hunger, food intake, and obesity in human subjects. Limited studies have been carried out on humans to check possible hepatotoxic, neurotoxic, and genotoxic effects of monosodium glutamate. Available literature showed that increased consumption of monosodium glutamate may be associated with harmful health effects. So, it is recommended to use common salt instead of it. Furthermore, intensive research is required to explore monosodium glutamate-related molecular and metabolic mechanisms.

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“…Так, Malik S.S. et al повідомляють про генотоксичні властивості глутамату натрію. Вірогідно, що даний ефект був зумовлений оксидативним стресом [10,11].…”

Section: вступunclassified

Mechanisms of Monosodium Glutamate Impact on Organs and Systems

Kinash¹,

Chupryna²,

Donets³

et al. 2021

Act. Probl. of the Modern Med.

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"Junk food" is very popular worldwide. Its taste requires various food additives, the most common of which is monosodium glutamate. Many authors describe functional and structure changes in the nervous, digestive, immune, respiratory and sexual systems that may be caused by monosodium glutamate. Therefore, the purpose of the study is to elucidate the mechanism of its actions on organs and systems. There has been suggested that monosodium glutamate mediates the phenomena of nervous cell apoptosis and acts as a powerful neurotoxin. Studies on rats demonstrated that the diet rich in monosodium glutamate created the preconditions for the development of epilepsy, disorders of emotional and adaptive reactions, hyperalgesia. Monosodium glutamate induced pronounced histological changes in the organs of the gastrointestinal tract, up to the manifestation of acute pancreatitis. Monosodium glutamate causes a destructive effect on the immune system as well. There was an increase in lymphocytes number that were destroyed by apoptosis, narrowing of the vascular lumens in the spleen, dilation of the venous lumen and blood supply in the lymph nodes. The effect on the respiratory system is remaining ambiguous. Atelectasis and pulmonary emphysema, fibrosis, oedema, and haemorrhage up to brown indurations have been reported under the monosodium glutamate consumption in animals. The negative effects of monosodium glutamate potentiated by smoking caused the activation of lipid peroxidation and protein oxidative modification. Monosodium glutamate caused sexual dysfunction in experimental rats that was also likely associated with hypothalamic damage, oxidative stress, and hormonal mechanisms. Thus, monosodium glutamate has been proven to produce a systemic effect on humans and animals. This food supplement has a complex mechanism of action, which can be indirect and direct. The indirect effects deteriorate normal functioning of target organs of the hypothalamus hormones, impacts the autonomic nervous system. The direct effects contribute to hypoxia and fibrosis in the organs, dysfunction of histohematological barriers and haemorrhages.

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Genotypes of GSTM1 and GSTT1: Useful determinants for clinical outcome of bladder cancer in Pakistani population

Cited by 4 publications

References 22 publications

Polymorphic Deletions of Glutathione S-Transferases M1, T1 and Bladder Cancer Risk in Algerian Population

Polymorphic Deletions of Glutathione S-Transferases M1, T1 and Bladder Cancer Risk in Algerian Population

Monosodium glutamate: Review on clinical reports

Mechanisms of Monosodium Glutamate Impact on Organs and Systems

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