Genotype distribution of methylenetetrahydrofolate reductase A1298C and C677T gene in Indonesian infertile men

Suryandari, Dwi Anita; Yurnadi, Yurnadi; Wiweko, Budi; Yunaini, Luluk

doi:10.13181/mji.v21i1.470

Cited by 2 publications

(2 citation statements)

References 15 publications

(13 reference statements)

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“…After data extraction, we excluded 4 articles from the meta-analysis. One of them had no controls [ 26 ] while one of them had no cases [ 27 ], besides, the other two studies were excluded as one did not provide detailed information needed for OR calculation [ 28 ] while the last one did not directly research about the genotype and male infertility risk [ 29 ]. Hence, we obtained 31 relevant articles that examined the association between MTHFR 677C>T and male infertility risk.…”

Section: Resultsmentioning

confidence: 99%

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

et al. 2015

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Background and ObjectivesMethylenetetrahydrofolate reductase (MTHFR) polymorphism may be a risk factor for male infertility. However, the epidemiologic studies showed inconsistent results regarding MTHFR polymorphism and the risk of male infertility. Therefore, we performed a meta-analysis of published case-control studies to re-examine the controversy.MethodsElectronic searches of PubMed, EMBASE, Google Scholar and China National Knowledge Infrastructure (CNKI) were conducted to select eligible literatures for this meta-analysis (updated to June 19, 2014). According to our inclusion criteria and the Newcastle-Ottawa Scale (NOS), only high quality studies that observed the association between MTHFR polymorphism and male infertility risk were included. Crude odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of association between the MTHFR polymorphism and male infertility risk.ResultsTwenty-six studies involving 5,575 cases and 5,447 controls were recruited. Overall, MTHFR 677C>T polymorphism showed significant associations with male infertility risk in both fixed effects (CT+TT vs. CC: OR = 1.34, 95% CI: 1.23–1.46) and random effects models (CT+TT vs. CC: OR = 1.39, 95% CI: 1.19–1.62). Further, when stratified by ethnicity, sperm concentration and control sources, the similar results were observed in Asians, Caucasians, Azoo or OAT subgroup and both in population-based and hospital-based controls. Nevertheless, no significant association was only observed in oligo subgroup.ConclusionsOur results indicated that the MTHFR polymorphism is associated with an increased risk of male infertility. Further well-designed analytical studies are necessary to confirm our conclusions and evaluate gene-environment interactions with male infertility risk.

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Section: Resultsmentioning

confidence: 99%

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

et al. 2015

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“…Sadewa et al (2002) conducted a profiling genetic variation of MTHFR C677T in the Javanese population. Furthermore, Suryandari et al (2012) also conducted genetic variations of MTHFR C677T among men in Indonesia, though their study primarily focused on its implication for fertility.…”

Section: Introductionmentioning

confidence: 99%

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

Yanuar,

Istyastono,

Virginia

2024

Indonesian J Pharm

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Neuropathy is the most common microvascular complication among type 2 diabetes mellitus (T2DM). Metformin consumption increases neuropathy risk. The Methylenetetrahydrofolate reductase (MTHFR) enzyme has confirmed its role in neuropathy. Metformin and MTHFR could decrease folate and induce hyperhomoscysteine. One of the common variants of the MTHFR gene is C677T and its located in the exon area. This study aimed to observe the association between variant C677T in the MTHFR gene and the risk of neuropathy among newly diagnosed T2DM patients with naive metformin. This cross-sectional study recruited 103 patients. The neuropathy risk was examined according to medical judgment through Neuropathy Symptom Score (NSS) and Neuropathy Disability Score (NDS) criteria. Genotyping C677T was performed using PCR-RFLP. This study found only one patient has a homozygote mutant, but more than 50% of patients were detected with allele mutants. There were no statistical differences in patient characteristics between CC and CT genotypes (p>0.05). Association between C677T and neuropathy risk was not significant statistically, either in the genotype model (p=0.97), allele model (p=0.82), and dominant model (p=0.91). There was still no significant association after adjusting for several confounding factors. We conclude that C677T in our population did not influence neuropathy risk. More specific criteria and laboratory parameters indicated neuropathy should be examined in the future study. Keywords: MTHFR, neuropathy, metformin, and T2DM

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Genotype distribution of methylenetetrahydrofolate reductase A1298C and C677T gene in Indonesian infertile men

Cited by 2 publications

References 15 publications

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

The Influence of MTHFR C677T Variants on Neuropathy Risk Among T2dm Patients Receiving Monotherapy Metformin

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