Genotoxizit�t von Phthalaten

Kleinsasser, N.; Kastenbauer, E.; Wallner, Barbara C.; Harrus, U.A.; Weissacher, Herbert

doi:10.1007/s001060050766

Cited by 6 publications

(1 citation statement)

References 10 publications

(11 reference statements)

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“…The GC-MS analysis of the organic extracts in the composite sample identified more than 30 organic compounds, and some of the compounds were mutagens, carcinogens and environmental endocrine disrupters. Dibutyl phthalate, diisobutyl phthalate, and mono (2-ethylhexyl) phthalate, which are mutagens, were identified in the samples [ 48 , 49 ]. Some organic pollutants that are not considered to be mutagens may generate mutagenic effects after metabolic activation in the body, such as di(2-ethylhexyl)-phthalate, benzothiazole, and N-(2-Naphthyl)aniline [ 50 – 52 ].…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China

Tang

LiXue

et al. 2015

PLoS ONE

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In the present study, the wastewater sample collected from the Dongming discharging river in Shijiazhuang city was analysed using both chemical analysis and biological assays including the Salmonella mutagenicity test, micronucleus test and single-cell gel electrophoresis. Chemical analysis of the sample was performed using gas chromatography mass spectrometry and inductively coupled plasma mass spectrometry. The Salmonella mutagenicity test was performed on Salmonella typhimurium TA97, TA98, TA100 and TA102 strains with and without S9 mixture. The mice received the wastewater in natura through drinking water at concentrations of 25%, 50%, and 100%. One group of mice was exposed for 2 consecutive days, and the other group of mice was exposed for 15 consecutive days. To establish the levels of primary DNA damage, single-cell gel electrophoresis was performed on treated mouse liver cell. The concentrations of chromium and lead in the sample exceeded the national standard (GB20922-2007) by 0.78 and 0.43-fold, respectively. More than 30 organic compounds were detected, and some of the detected compounds were mutagens, carcinogens and environmental endocrine disrupters. A positive response for Salmonella typhimurium TA98 strain was observed. Mouse exposure via drinking water containing 50% and 100% of wastewater for 15 consecutive days caused a significant increase of MN frequencies in a dose-response manner. Mouse exposure via drinking water containing 50% and 100% of wastewater for 15 consecutive days caused a significant increase of the Olive tail moments in a dose-response manner. All the results indicated that the sample from the Dongming discharging river in Shijiazhuang city exhibited genotoxicity and might pose harmful effects on the local residents.

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Section: Discussionmentioning

confidence: 99%

Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China

Tang

LiXue

et al. 2015

PLoS ONE

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Karzinogene und kokarzinogene Effekte von Metallen und Ethylalkohol in humanen Speicheldr�senzellen

Harréus

Baumeister

Wallner

et al. 2005

HNO

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Miniorgankulturen humaner nasaler Mukosa

Wallner

Harréus

Gamarra

et al. 2005

HNO

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This three dimensional mini-organ culture system proved to be very helpful in characterizing volatile and ingestive xenobiotics potentially hazardous to humans. Beside the information concerning genotoxicity, it allows cytological and immunological studies. In contrast to investigations with fresh specimens, repetitive or chronic exposure to xenobiotics is possible in mucosal cells with their epithelial structural integrity. Therefore, mini-organ cultures of human upper aerodigestive tract epithelia represent a model closely resembling the in vivo situation.

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Genotoxizit�t von Phthalaten

Cited by 6 publications

References 10 publications

Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China

Genotoxicity Evaluation of Irrigative Wastewater from Shijiazhuang City in China

Karzinogene und kokarzinogene Effekte von Metallen und Ethylalkohol in humanen Speicheldr�senzellen

Miniorgankulturen humaner nasaler Mukosa

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