Karzinogene und kokarzinogene Effekte von Metallen und Ethylalkohol in humanen Speicheldr�senzellen

Harréus, Ulrich; Baumeister, Philipp; Wallner, Barbara C.; Berghaus, Alexander; Kleinsasser, N.

doi:10.1007/s00106-004-1093-1

Cited by 8 publications

(1 citation statement)

References 20 publications

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“…To our knowledge, there are very few studies that address the effects of oxidative stress on salivary glands in humans and their connection to pathology, as follows: two studies on oxidative stress markers in patients with PG tumors [ 34 , 35 ], a review that deals with the diseases that impair the salivary function and their treatment [ 36 ], an article regarding the oxidative markers in HIV patients [ 37 ], seven studies on cell cultures from human salivary glands [ 38 , 39 , 40 , 41 , 42 , 43 , 44 ], and some studies about salivary gland damage by oxidative stress in systemic diseases, such as arthritis [ 45 , 46 ], Alzheimer’s disease [ 47 ], stroke [ 48 ], Sjogren’s syndrome [ 49 , 50 ], chronic heart failure [ 51 ], psoriasis [ 52 ], and chronic kidney disease [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Ungureanu,

Grădinaru,

Ghiciuc

et al. 2023

Medicina

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Background and Objectives: Oxidative stress is involved in the alterations at the level of salivary glands, being the cause of oral pathologies like xerostomia, periodontitis, gingivitis, leucoplakia, and cancer. It is known that antioxidants can reverse changes induced by drugs or other chemicals in some organs, but the question is whether these substances can reduce or revert the effects of oxidative stress at the salivary gland level. Our aim was to find histopathological data at the level of salivary glands supporting the hypothesis of the reversal of oxidative stress-induced changes after the treatment with substances with antioxidant effect. Materials and Methods: A systematic search was conducted in PubMed, Science Direct, and Springer databases, including research articles on oxidative stress histological aspects and oxidative stress biomarkers induced by drugs or other chemicals on salivary glands. Results: Out of 1756 articles, 25 articles were selected with data on tissue homogenate used for biochemical analysis of oxidative and antioxidative markers, along with routine hematoxylin eosin (HE) and immunohistochemical analysis used for histopathological and immunohistochemical diagnosis. Drugs (antineoplastic drugs, antibiotics, and analgesics), alcohol, heavy metals, and fluoride can cause oxidative stress, resulting in morphological changes in different tissues, including in salivary glands. There are many antioxidants but only a few were evaluated regarding the effects on salivary glands in animal studies, such as hesperidin and selenium, which can reverse the damage induced by cyclophosphamide; 10-dehydrogingerdione (10-DHGD), a compound extracted from ginger, which has a protective effect against the oxidative stress and apoptosis induced by tramadol; and glycyrrhizic acid, which may repair the injuries incurred after the administration of sodium nitrite. Conclusions: Substances such as hesperidin, selenium, 10-dehydrogingerdione, and glycyrrhizic acid are antioxidants with proven restorative effects on salivary glands for the damage induced by oxidative stress after exposure to drugs and other chemical substances; however, demonstrating their similar effects in human salivary glands is challenging.

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Section: Discussionmentioning

confidence: 99%

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Ungureanu,

Grădinaru,

Ghiciuc

et al. 2023

Medicina

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Miniorgankulturen humaner nasaler Mukosa

Wallner

Harréus

Gamarra

et al. 2005

HNO

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This three dimensional mini-organ culture system proved to be very helpful in characterizing volatile and ingestive xenobiotics potentially hazardous to humans. Beside the information concerning genotoxicity, it allows cytological and immunological studies. In contrast to investigations with fresh specimens, repetitive or chronic exposure to xenobiotics is possible in mucosal cells with their epithelial structural integrity. Therefore, mini-organ cultures of human upper aerodigestive tract epithelia represent a model closely resembling the in vivo situation.

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Trägt Nikotin zur Krebsentstehung im oberen Aerodigestivtrakt bei?

Kleinsasser

Sassen

Semmler

et al. 2006

HNO

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Karzinogene und kokarzinogene Effekte von Metallen und Ethylalkohol in humanen Speicheldr�senzellen

Abstract: In this investigation, sodium dichromate was identified as genotoxic in association with human salivary gland tissue. These effects could be increased by CdSO(4), reinforcing DNA damage based on oxidative stress.

Cited by 8 publications

References 20 publications

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review

Miniorgankulturen humaner nasaler Mukosa

Trägt Nikotin zur Krebsentstehung im oberen Aerodigestivtrakt bei?

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