Genotoxicity studies with Cuman L in Drosophila melanogaster

Abstract

Cuman L, a dithiocarbamate fungicide, was tested for its ability to induce sex-linked recessive lethals (SLRLs) and II-III chromosome translocations in Drosophila melanogaster by the larval feeding method. The three concentrations of Cuman L, of 20, 40, and 60 microliters/100 ml, induced significant (P less than 0.01) increases in SLRLs but failed to induce any translocations.

Effect of Thiovit® Jet on the structure of thoracic microtrichia/trichomes in Drosophila melanogaster

“…Similarly Vargová et al (1980) could not show any mutagenic effect with the fungicide trymorphamide in Drosophila . However, Hemavathy and Krishnamurthy (1989) were successful in describing the mutagenic potential of Cuman-L, a dithiocarbamate fungicide. Interestingly, the fungicides captan and captafol are reported to cause somatic mutation in wing cells of D. melanogaster (Rahden-Staron, 2002).…”

Further in vitro and in vivo mutagenicity assays with thiram and ziram fungicides: Bacterial reversion assays and mouse micronucleus test

“…Ziram was directly mutagenic in S. typhimurium (mainly in base substitution sensitive strains) [3 3,181 and in a repair test in Bacillus subtilis [8]. Samples of both technical ziram (as rubber chemical) and of a formulate containing ziram as the active ingredient were positive in the sex linked recessive lethals (SLRL) test and in somatic and germ-line mosaic assays in Drosophila [ 1 1,19,20]. In in vitro cultured mammalian cells, ziram (technical grade) induced high frequencies of chromosome aberrations (and no SCE) in Chinese hamster ovary cells both with and without S9 1211 and-tested only without S9-forward mutations at the tk locus in mouse lymphoma cells [22].…”