Genotoxicity of <i>Achillea millefolium</i> essential oil in diploid cells of <i>Aspergillus nidulans</i>

Sant’Anna, Juliane Rocha de; Franco, Claudinéia Conationi da Silva; Miyamoto, Cláudia Tiemi; Cunico, Miriam Machado; Miguel, Obdúlio Gomes; Côcco, Lílian Cristina; Yamamoto, Carlos Itsuo; Corrêa, Cirino; Castro-Prado, Marialba Avezum Alves de

doi:10.1002/ptr.2596

Cited by 23 publications

(10 citation statements)

References 28 publications

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“…This EO exerted genotoxic effects against the fungal cells and suppressed the development of spores. [208] As the study mentioned below shows, the fungistatic activity of EOs can be influenced by the existing pH level. Penicillium verrucosum, Penicillium expansum and A. ochraceus were more sensitive to Ocimum gratissimum L. (Lamiaceae) EO compared to the EOs of Thymus vulgaris L. (Lamiaceae) and C. citratus.…”

Section: Juniperus Phoenicea L (Cupressaceae)mentioning

confidence: 98%

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

Lang

Buchbauer

2011

Flavour & Fragrance J

340

209

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The antimicrobial activity of essential oils is discussed in this review taking in account studies which were published in the period of time from 2008 until September 2010. Furthermore, the most important methods to examine the antimicrobial efficiency of essential oils are presented. The studies are divided into the following two groups, namely antibacterial and antifungal active agents depending on the activity of the applied essential oil against the test microorganisms. Various interesting possible applications are revealed such as the use of essential oils instead of synthetic drugs to circumvent the increasing resistance of some pathogens. Moreover, they could not only be used for the therapy of infectious illnesses, but also as preservatives in the food industry. A further possibility is, among others, the application of essential oils in skin products in order to treat or avoid dermal infections. Additionally, the prevalent constituents of the individual antimicrobial active essential oils are elaborated.

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Section: Juniperus Phoenicea L (Cupressaceae)mentioning

confidence: 98%

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

Lang

Buchbauer

2011

Flavour & Fragrance J

340

209

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“…Achillea millefolium L. (Asteraceae), commonly known as yarrow, is an ancient remedial herb native to Europe and is used to treat wounds, gastrointestinal and hepatobiliary disorders, hemorrhages, spasmodic diseases, inflammation, headaches, and pain [5, 6]. Phytochemical screenings revealed that chemical constituents of A. millefolium (AM) present several secondary metabolites, including essential oils, sesquiterpenes, the alkaloid achilleine, steroids, triterpenes, and flavonoids, as presented by De Souza et al [7].…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic Effect of Medicinal PlantsAchillea millefoliumandBauhinia forficata In Vivo

Düsman

Almeida

Coelho

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The investigation of traditionally used medicinal plants is valuable both as a source of potential chemotherapeutic drugs and as a measure of safety for the continued use of these medicinal plants. Achillea millefolium L. (AM) is an ancient remedial herb native to Europe that is used to treat wounds, gastrointestinal and hepatobiliary disorders, inflammation, headaches, and pain. Bauhinia forficata Link (BF), an Asiatic plant, is one of the most commonly used plants in folk medicine against diabetes. The aim of this study was to evaluate the cytotoxic and antimutagenic potential of aqueous extracts of AM and BF on bone marrow cells of Wistar rats treated in vivo. These plant extracts possess considerable antioxidant activity due to the presence of flavonoids and phenolic compounds. These compounds were determinants to noncytotoxic and antimutagenic/protective action of these plants, that reduced statistically the percentage of chromosomal alterations induced by the chemotherapeutic agent cyclophosphamide in simultaneous (AM, 68%; BF, 91%), pre- (AM, 68%; BF, 71%), and post-treatment (AM, 67%; BF, 95%). Therefore, the results of this study indicate that extracts of A. millefolium and B. forficata have antimutagenic potential and that their consumption can benefit the health of those using them as an alternative therapy.

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“…Monografias no assunto encontram-se postadas na Farmacopéia Portuguesa (Cunha & Roque, 2009) e na British Herbal Pharmacopoeia (1996). Investigações fitoquímicas de extratos alcoólicos levaram ao isolamento de pequenos metabólitos, como lactonas, sesquiterpenos e flavonóides (Sant'Anna et al, 2009), sugerindo o controle de fitopatógenos pelos componentes do óleo essencial de mil folhas. Schwan-Estrada et al (2000) quantificaram a produção das fitoalexinas deoxiantocianidinas em mesocótilos de sorgo, e de gliceolinas em cotilédones de soja, após tratamento com extratos de quinze plantas medicinais (incluindose mil folhas), e apontaram o potencial uso desses extratos no controle de fitopatógenos e na indução de resistência das plantas contra doenças.…”

Section: Introductionunclassified

Fitodefensivos em plantas medicinais: macromoléculas hidrofílicas de folhas de mil folhas (Achillea millefolium L.) inibem o crescimento in vitro de bactérias fitopatogênicas

Tessarollo¹,

Carrijo²,

Barbosa³

et al. 2013

Rev. bras. plantas med.

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RESUMO:Extratos aquosos da planta medicinal Achillea millefolium contêm macromoléculas de interesse para desenvolver fitodefensivos para a agricultura. Duas frações de mil folhas foram obtidas por ultrafiltração, E1 (contendo moléculas maiores que 30 kDa), e E3 (peptídeos entre 1 e 10 kDa) que inibiram o crescimento das bactérias fitopatogênicas Ralstonia solanacearum, gramnegativa, e Clavibacter michiganensis subsp. michiganensis, gram-positiva, com dependência de concentração. Os valores de concentração inibitória mínima (CIM) para ambos os extratos e bactérias foram baixos, entre 20 e 80mM. A CIM relativa à proteína total evidenciou a presença de macromoléculas muito ativas em E3, embora com baixa concentração proteica. E3 se aplica à prospecção de peptídeos antimicrobianos. Estimar a CIM relativa à quantidade de amostra vegetal valorizou o potencial antimicrobiano natural de E1, que contém alta concentração proteica. E1e E3 se aplicam ao desenvolvimento de fitodefensivos para uso biotecnológico. A ultrafiltração fracionou as amostras de forma nativa, rápida, e com baixo custo; além de dessalinizar, clarificar, purificar, e concentrar E1 e E3. Esse estudo inédito sobre a separômica e a ação antimicrobiana de extratos macromoleculares aquosos de mil folhas sugere que plantas cicatrizantes podem apresentar grande potencial para desenvolver fitodefensivos agrícolas naturais não danosos, à semelhança de medicamentos fitoterápicos.Palavras-chave: Macromoléculas de defesa, peptídeos antimicrobianos, Ralstonia solanacearum, Clavibacter michiganensis subsp. michiganensis, concentração inibitória mínima relativa.ABSTRACT: Agrochemicals in medicinal plants: hydrophilic macromolecules from leaves of "mil folhas" (Achillea millefolium L.) inhibit in vitro growth of phytopathogenic bacteria. Aqueous extracts from the medicinal plant Achillea millefolium contain macromolecules of interest to develop agrochemicals for agriculture. Two fractions of "mil folhas" were obtained by ultrafiltration, E1 (containing molecules larger than 30 kDa) and E3 (peptides between 1 and 10 kDa), which inhibited the growth of phytopathogenic bacteria Ralstonia solanacearum, gramnegative, and Clavibacter michiganensis subsp. michiganensis, gram-positive, concentrationdependent. The values of minimum inhibitory concentration (MIC) for both extracts and both bacteria were low, ranging from 20 to 80mM. The MIC relative to total protein evidenced the presence of very active macromolecules in E3, although showing low protein concentration. E3 applies to the prospection of antimicrobial peptides. The estimated MIC relative to the amount of plant sample valued the natural antimicrobial potential of E1, which contains high protein concentration. E1 and E3 can be used in the development of agrochemicals for biotechnological purposes. The ultrafiltration procedure fractionated the samples in a rapid and native way and at a low cost; it also desalted, clarified, concentrated and purified both E1 and E3. This pioneering study on the separomics and on the a...

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Genotoxicity of Achillea millefolium essential oil in diploid cells of Aspergillus nidulans

Cited by 23 publications

References 28 publications

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. A review.

Antimutagenic Effect of Medicinal PlantsAchillea millefoliumandBauhinia forficata In Vivo

Fitodefensivos em plantas medicinais: macromoléculas hidrofílicas de folhas de mil folhas (Achillea millefolium L.) inibem o crescimento in vitro de bactérias fitopatogênicas

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