Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential

Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia

“…In particular, an increasing number of Chinese herbal products are now being reported as hepatotoxic . We have also found the hepatotoxic potentials of well-known traditional medicines such as Sophorae radix and Genkwa flos in 13-week repeatdose toxicity study (Che et al, 2015;Yun et al, 2015a). The CH extract induced no treatment-related changes in serum AST and ALP as indicators for hepatocellular damage (Han et al, 2011) and biliary obstruction (Ozdil et al, 2010), respectively, whereas its treatment resulted in a significant elevation in serum ALT, a marker for screening for liver disease (Mukinda and Syce, 2007), in a dosedependent manner.…”

“…Since traditional medicines are often perceived as "natural" and therefore free from side effects (Markman, 2002;Shin et al, 2013), a comprehensive analysis of safety issues for the majority of herbal medicine has not been fully established although we recently found that various beneficial herbs have toxic side effects (Che et al, 2014(Che et al, , 2015Yun et al, 2015a). It has been reported that C. racemosa induced the acute liver injury (Enbom et al, 2014;Muqeet Adnan et al, 2014;NIDDK, 2015).…”

Toxicity Evaluation of Anisomeles indica Kuntze Leaf Flavonoid Fraction

“…However, there are no available facts of degree of excellence, reliability and efficacy of majority of the generally used herbal recipes. Recently it has been established that, poisonous side effects combined quite with diverse beneficial herbs [6][7][8]. These features need to consider among the visible effects of absolute examinations carried out for the toxicity assessment of these folk medicines and herbal recipes.…”

Evaluation of subchronic (13week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos

“…In recent studies, we demonstrated that effective herbs, including Paecilomyces tenuipes and Sophorae radix, have toxic side effects (Che et al, 2014;Che et al, 2015). Raw GF have also been commonly recognized to be toxic, and for this reason, raw GF are traditionally processed with vinegar to remove the toxicity (Geng et al, 2013).…”