Genotoxic studies in hypertensive and normotensive rats treated with amiodarone

Angiotensin II-induced hypertension dose-dependently leads to oxidative stress and DNA damage in mouse kidneys and hearts

“…Increased 8-oxodG was found in urine and DNA of humans and rats [56,57]. Only one study [58] until now indicated the possibility of a mutagenic effect of hypertension, reporting chromosomal aberrations in spontaneously hypertensive rats. Low salt diet is known to also activate the renin-angiotensin-aldosterone system (RAAS) [59].…”

Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action

“…In some studies DNA damage in peripheral lymphocytes of hypertensive patients was measured with the comet assay and an increased number of DNA strand breaks was found in hypertension (Demirbag et al, 2005;Park et al, 2005;Gur et al, 2007;Yildiz et al, 2008). Evidence of genomic damage was up to now only presented in one publication: an increase of chromosomal aberrations was obser-ved in spontaneously hypertensive rats (Almeida et al, 2008).…”

Ameliorative effect of grapefruit juice on amiodarone–induced cytogenetic and testicular damage in albino rats

“…On the other hand, mitotic index decreased by the treatment with this drug. Similarly, Almeida et al reported that amiodarone caused an increase in chromosomal aberrations and abnormal metaphase in bone marrow cells of Wistar-Kyoto rats [7] .…”

“…Amiodarone may accumulate within many organs including the testis and was associated with epididymitis [4,5] . It induced apoptosis in H9c2 cardiac cells and chromosomal aberrations in rats [6,7] .…”