Ameliorative effect of grapefruit juice on amiodarone–induced cytogenetic and testicular damage in albino rats

Sakr, Saber A.; Zoil, Mohamed El-said; El-Shafey, Samraa

doi:10.1016/s2221-1691(13)60116-1

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…The results suggest that the grapefruit may reduce the frequency of chromosomal aberrations, sister chromatid exchange (SCE) and micronuclei, as well as single or double strand breaks of DNA produced by 2-amino-1-methyl-6-phenylimidazo (4,5- b ) pyridine, aflatoxin B 1 (AFB 1 ), daunorubicin, ifosfamide, benzo( a )pyrene, hydrogen peroxide (H 2 O 2 ), amiodarone, and X-rays. In the case of the naringin, this compound has shown its genoprotector capacity against the ifosfamide, H 2 O 2 , cytosine-beta-arabin-furanoside (Ara-C), bleomycin, and cadmium ( Table 4 ) [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Antigenotoxic Fruitsmentioning

confidence: 99%

Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

et al. 2017

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Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown potential antigenotoxicity in a variety of fruits. In this review (Part 1), we present an overview of research conducted on some fruits (grapefruit, cranberries, pomegranate, guava, pineapple, and mango) which are frequently consumed by humans, as well as the analysis of some phytochemicals extracted from fruits and yeasts which have demonstrated antigenotoxic capacity in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus and comet assay.

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Section: Antigenotoxic Fruitsmentioning

confidence: 99%

Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

et al. 2017

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“…The antioxidant and testicular protective effects of GP have been confirmed by many investigators. 14,[40][41][42][43][44] Despite these antioxidant properties of GP, the combined use of GP with MTZ in our study resulted in aggravation of both the infertility and neurotoxicity side effects of MTZ. This adverse effect has been proven at both the biochemical and histopathological levels and can be explained by the possible pharmacokinetic interaction between MTZ and GP.…”

Section: Discussionmentioning

confidence: 67%

Thiamine deficiency and oxidative stress induced by prolonged metronidazole therapy can explain its side effects of neurotoxicity and infertility in experimental animals: Effect of grapefruit co-therapy

et al. 2020

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We aimed to explore the possible neurotoxicity and infertility mechanisms of prolonged metronidazole (MTZ) use and the effects of antioxidant grapefruit (GP) co-therapy on MTZ-induced complications. Sixty male albino Wistar rats were divided into four groups ( n = 15 each). Group I (control group) received 1% dimethyl sulfoxide (27 ml/ kg/day), group II (MTZ group) received MTZ (400 mg/kg/day), group III (MTZ + GP) received MTZ (400 mg/kg/ day) plus GP juice (27 ml/kg/ day) and group IV (GP group) received GP juice (27 ml/kg) for 60 days. Semen analyses were performed. Free testosterone, gonadotrophin (follicle-stimulating hormone (FSH) and luteinizing hormone) and thiamine levels were measured. Samples of cerebellar, testicular and epididymal tissues were used for both colorimetric assays of oxidative stress markers and histopathological examinations. Significant decreases in the sperm count, percent total sperm motility, serum thiamine levels, free testosterone levels and FSH levels were observed in the MTZ and MTZ + GP groups ( p < 0.05 for all parameters). Significantly higher oxidative stress levels ( p < 0.05) were observed in the cerebellar and testicular tissue homogenates of these groups than in those of the control group, and associated disruptions in the cerebellar, testicular and epididymal structures were apparent compared to those of the control group. Although the GP group showed a significantly higher sperm count and significantly lower oxidative stress than the control group ( p < 0.05), with histological similarity to the control group, the GP group exhibited significantly higher prolactin levels and lower free testosterone and FSH levels than the control group ( p < 0.05). Oxidative stress and decreased thiamine levels could explain the MTZ-induced neurotoxicity and infertility side effects that aggravated by GP co-administration.

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“…( 15 ). Propolis was administered via an orogastric tube ( 16 ) for five consecutive days. The technique suggested by Heddle ( 17 ) was followed in preparing bone marrow slices for the micronuclear test ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran

Kurdi¹,

Aljeddani²

2016

Electron physician

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ObjectiveThis study was carried out to investigate the ability of Propolis to ameliorate the adverse cytogenetic effects of Dacarbazine on bone marrow cellsMethodsIn this experimental in vivo study, 18 mice were used, divided into four groups: control group; Propolis-treated group (treated with 50mg/kg Propolis); and Dacarbazine-treated group (treated with 3.5mg/kg Dacarbazine). The fourth, fifth, and sixth were treated with Dacarbazine and Propolis as pre 2h, post 2h, and concomitant treatment. After five days, the Bone Marrow (BM) samples were obtained for cytogenetic investigation.ResultsThe in vivo studies revealed that Dacarbazine induced an abnormalities in polychromatic erythrocytes cells (PECs) as increase of cell with micronuclei, while the dual treatment accompanied with improvement of this abnormalities.ConclusionsIt could be concluded that there are protective effects of Propolis against the adverse effects of Dacarbazine. It could be recommended to use Propolis as an adjuvant with chemotherapeutic agents.

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Ameliorative effect of grapefruit juice on amiodarone–induced cytogenetic and testicular damage in albino rats

Cited by 16 publications

References 31 publications

Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

Thiamine deficiency and oxidative stress induced by prolonged metronidazole therapy can explain its side effects of neurotoxicity and infertility in experimental animals: Effect of grapefruit co-therapy

Reduction of Dacarbazine cytogenetic effects on somatic cells in male mice using bee glue (Propolis) to manifest the scientific miracles in the Quran

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