Genotoxic potential of cyfluthrin

İla, Hasan Basri; Topaktaş, Mehmet; Rencüzoğulları, Eyyüp; Kayraldız, Ahmet; Dönbak, Lale; Dağlıoğlu, Yusuf Kenan

doi:10.1016/j.mrgentox.2008.07.005

Cited by 34 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results contradict our findings. On the other hand, Alloxydim sodium has cytotoxic effect due to decreasing the NDI and similar results have been reported by Ila et al (2008) and İstifli and Topaktaş (2013).…”

Section: Discussionsupporting

confidence: 87%

Micronucleus assay in human lymphocytes after exposure to alloxydim sodium herbicide in vitro

et al. 2014

View full text Add to dashboard Cite

This study evaluates the cytotoxic and genotoxic potential of alloxydim sodium using micronucleus (MN) assay, in human peripheral lymphocytes. MN assay was used to investigate the genotoxic effects of alloxydim sodium in human peripheral lymphocytes treated with 250, 500, 750, 1,000 lg/ml concentrations of alloxydim sodium for 24 and 48 h. Solvent, negative and positive controls were also used in the experiments in parallel. The obtained results were evaluated in statistical analyses by using Dunnett-t test (two sided) and p \ 0.05 was accepted as significant. Alloxydim sodium significantly increased the MN formation compared with the negative control, at both 750 and 1,000 lg/ml concentrations and treatment periods. We also evaluated the nuclear division index (NDI) for cytotoxicity of this pesticide in the experiment, and finally observed a significant decrease of the NDI values at all concentrations of alloxydim sodium and at both treatment periods.

show abstract

Section: Discussionsupporting

confidence: 87%

Micronucleus assay in human lymphocytes after exposure to alloxydim sodium herbicide in vitro

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Pulverisation is as similar as CLD15 and CHD30. The alteration in mitotic chromosomes after the carbafuran treatment is similar with the work of (Ila et al, 2008;Tyrkiel et al, 2001).…”

Section: Comparision Between Carbafuran Lower Dose (Cld15) With Highesupporting

confidence: 88%

Effect of Carbafuran Pesticide on Mitotic Chromosomes of Mus musculus

Kumari

Verma

Roy

2018

Int J Appl Sci Biotechnol

View full text Add to dashboard Cite

The Genotoxic effect of the carbafuran pesticide was evaluated in the metaphasic chromosomes of bone marrow cells of female Swiss albino mice, Mus musculus . Six week old mice were put into different groups(six mice per group) and treatment were done according to experimental plan (CLD15 i.e. lower dose =30ppm or 0.03mg/ml and CHD30 i.e. higher dose =300ppm or 0.3mg/ml).The test material was administered orally for 15 days in CLD15 and for 30 days in CHD30 test groups of female mice. The result revealed that the frequency of chromosomal abnormalities i.e. structural and numerical changes were11.5% in control, 74.0%in CLD15 and 99.0%in CHD30, respectively in bone marrow cells of female mice.

show abstract

“…The clastogenic response of various compounds is often associated with high toxicity (Müller and Sofuni 2000). A decrease in mitotic index has also been reported for many other pesticides such as etoxazole (Rencüzogulları et al 2004), afugan (Yüzbaşıoglu et al 2006), conan 5FL (Yılmaz et al 2008), cyfluthrin (Ila et al 2008), dichlorvos (Eroglu 2009), acephate (Ö zkan et al 2009) and thiacloprid (Timoroglu et al 2012) in cultured human lymphocytes. Dicapthon significantly increased micronuclei frequency at all concentrations (except at the 25 lg/mL concentration in the 24 h application) in a dose dependent manner compared to untreated and solvent controls.…”

Section: Discussionmentioning

confidence: 91%

“…Dicapthon may induce MN because of its clastogenic effects. Various pesticides such as malathion (Giri et al 2002), atrazine (Kligerman et al 2000), cypermethrin (Undeger and Başaran 2005), afugan (Yüzbaşıoglu et al 2006), hexachlorobenzene (Ennaceur et al 2008), cyfluthrin (Ila et al 2008), dichlorvos (Eroglu, 2009(Eroglu, ), acephate (Ö zkan et al 2009) and thiacloprid (Timoroglu et al 2012) have also caused the formation of micronuclei in different test systems. The reduction in the NDI observed for lymphocytes cultured with 100 and 200 lg/mL indicates that the dicapthon, at high concentrations, has a cytostatic effect via inhibition of cell cycle progression.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity and genotoxicity of dicapthon insecticide

Liman

2014

Cytotechnology

View full text Add to dashboard Cite

Mutagenic and genotoxic effects of dicapthon were investigated by using the bacterial reverse mutation assay in Salmonella typhimurium TA97, TA98, TA100 and TA102 strains with or without metabolic activation system (S9 mix), and chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) tests in human peripheral blood lymphocytes in vitro. Dicapthon was dissolved in dimethyl sulfoxide for all test systems. 0.1, 1, 10 and 100 lg/plate doses of dicapthon were found to be weakly mutagenic on S. typhimurium TA 98 without S9 mix. The human peripheral lymphocytes were treated with four experimental concentrations of dicapthon (25, 50, 100, and 200 lg/mL) for 24 and 48 h. Dicapthon increased the frequency of SCE only at the 100 lg/mL concentration for the 24 and 48 h applications. Dicapthon also induced abnormal cell frequency, CA/cell ratio and frequency of MN dose dependently for 24 and 48 h. Dicapthon showed a statistically significant cytotoxic effect by decreasing the mitotic index in all concentrations and a cytostatic effect by decreasing nuclear division index in 100 and 200 lg/mL concentrations for both treatment periods when compared with both untreated and solvent controls. These values decreased also in a dose dependent manner.

show abstract

Genotoxic potential of cyfluthrin

Cited by 34 publications

References 41 publications

Micronucleus assay in human lymphocytes after exposure to alloxydim sodium herbicide in vitro

Micronucleus assay in human lymphocytes after exposure to alloxydim sodium herbicide in vitro

Effect of Carbafuran Pesticide on Mitotic Chromosomes of Mus musculus

Mutagenicity and genotoxicity of dicapthon insecticide

Contact Info

Product

Resources

About