Genotoxic effects of PM10 and PM2.5 bound metals: metal bioaccessibility, free radical generation, and role of iron

Yadav, Suman; Kumbhar, Navanath; Jan, Rohi; Roy, Ritwika; Satsangi, P. Gursumeeran

doi:10.1007/s10653-018-0199-4

Cited by 17 publications

(6 citation statements)

References 91 publications

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“…On the other hand, the factors affecting the increase in the O 3 contents might involve increased air temperatures and the presence of other air contaminants, i.e., NO 2 , CO, and volatile organic compounds (VOCs). Observed higher contents of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in winter months in comparison to summer months could result from their content in PM particles [ 60 ]. Air quality improvement in Kraków is hindered by the adverse location of the city in the river valley, which is described in the Introduction section.…”

Section: Discussionmentioning

confidence: 99%

“…Traffic remains a continuous problem because the number of vehicles keeps increasing in Kraków, while the average age of cars was estimated at about 14 years in Poland in 2018. Higher contents of SO 2 , CO, C 6 H 6 , PM10, and PM2.5 and heavy metals and PAHs, contained in PM particles [ 60 ] observed in winter months in comparison to summer months, indicated that local emission sources were the main causes of pollution [ 6 , 7 ]. It needs to be added here that in the past several years, winters become milder, and freezing temperatures shifted from November to March in Poland [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

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The Condition of Air Pollution in Kraków, Poland, in 2005–2020, with Health Risk Assessment

Traczyk

Gruszecka‐Kosowska

2020

IJERPH

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Aims: Air quality changes with human health risk assessment were investigated. Methods: The measurement results obtained by the Regional Environmental Protection Inspectorate (REPI) in Kraków and our deposited particulate-matter (PM) analysis, as well as United States Environmental Protection Agency (USEPA) methodology of risk assessment were used in the study. Results: Annual pollutant contents kept decreasing, with the exception of O3. However, the permissible annual levels were exceeded in the cases of PM10, PM2.5, and NO2. Increased contents of SO2, CO, C6H6, PM10, and PM2.5, as well as of As, Pb, Cd, Ni, and polycyclic aromatic hydrocarbons (PAHs) in PM particles during winter months indicated that house heating was the source of pollution. Due to no significant change in the monthly NO2 contents, this measurement was used as an indicator of traffic sources of pollution. In winter months, the allowable 24 h PM2.5 and PM10 contents were constantly exceeded. PM was identified as the most significant air pollutant. Enrichment factors revealed that deposited PM was enriched with heavy metals. The potential ecological risk (ERI) was determined to be very high for Cd, considerable for Zn, and low for As, Co, Cr, Cu, Ni, Pb, and Tl. The total non-carcinogenic risk indices (HQ) for both adults (HQ = 15.0) and children (HQ = 26.4) exceeded the acceptable value of 1. The total carcinogenic risk indices (CR) for both adults (CR = 1.51 × 10−4) and children (CR = 1.77 × 10−4) exceeded the acceptable level of 1 × 10−4. Conclusions: In the years 2005–2020, a general decreasing tendency of annual pollutant contents was observed. However, the permissible contaminant contents were still exceeded. PM2.5, BaP, PM10, and NO2 were determined as the most dangerous pollutants in inhalational pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Condition of Air Pollution in Kraków, Poland, in 2005–2020, with Health Risk Assessment

Traczyk

Gruszecka‐Kosowska

2020

IJERPH

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“…Zhao Li et al [13] believed that free radicals could oxidize a large number of unsaturated fatty acids in human body and modify fatty acids to form peroxidation lipids and further produce aldehydes, which could cross-link with proteins, lipids and nucleic acids. Yadav et al [14] found that free radicals could attack DNA in organisms, cause the denaturation of nucleic acids, affect their functions of transmitting information and their characteristics of transcription and replication, and lead to the decreased protein synthesis ability and synthesis errors. Asowata et al believed that free radicals might cause the denaturation of proteins, thereby triggering their own immune responses.…”

Section: Free Radicalsmentioning

confidence: 99%

Advances in the Pathogenesis of Perimenopausal Syndrome

Cao¹,

Lu²,

Chen³

et al. 2020

PAR

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Perimenopause syndrome refers to the syndrome of the disorders of multiple systems of women around menopause caused by the reduction in secreted estrogen and is also known as menopause syndrome. Its pathogenesis involves increasing age, the abatement of ovarian function, and psychological change caused by the increasing life pressure. The above factors lead to physical and mental changes in postmenopausal women. This paper summarizes the pathogenesis of perimenopause from the perspective of gene studies and existing experimental studies and provide some ideas for clinical treatment and research.

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“…Entre los antioxidantes exógenos tenemos la vitamina C, E, polifenoles como quercetina, kaempferol, antocianinas y curcuminoides. Los compuestos polifenólicos tienen una potente actividad in vitro debido a su alta reactividad como donador de hidrogeno y electrones (5,6,7) ; los principales curcuminoides en la cúrcuma son polifenoles: curcumina (diferuloilmetano), demethoxycurcumin (curcumin ll), y bisdemethoxycurcumin (curcumin lll), los tres imparten la pigmentación amarilla distintiva; la curcumina es el constituyente polifenólico más activo de naturaleza hidrofóbica, son referidas como potenciales sustancias antioxidantes, pero a nivel nacional hasta el momento no se ha determinado la capacidad antioxidante.…”

Section: Introductionunclassified

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

Rafael¹,

Medina²,

Figueroa³

et al. 2019

Rev. per. med. integr.

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Objetivo. Determinar los parámetros físico-químicos y la capacidad antioxidante in vitro del extracto crudo y etanólico de Curcuma longa L. Materiales y métodos. Se obtuvieron dos extractos vegetales: crudo y en 96% de etanol. Se determinaron las características físico-químicas y la presencia de principales grupos de metabolitos mediante screening fitoquímico, asociados con actividad biológica. El contenido de polifenoles totales se determinó mediante el ensayo de Folin-Ciocalteu y la actividad antioxidante de los extractos se evaluó in vitro mediante el ensayo 2,2-difenil-1-picrilhidrazilo (DPPH) y 2,2-azinobis-[3 etilbenzotiazolin-6-sulfónico] (ABTS). Resultados. Los extractos crudo y etanólico de Curcuma longa L. presentaron una densidad relativa 0,8144 y 1,0536g/mL, respectivamente. Respecto al screening fitoquímico, se logró identificar algunos metabolitos en ambos extractos, destacando compuestos fenólicos, flavonoides, alcaloides y heterósidos. El contenido de fenoles totales fueron 252,05 y 296,43 (μg EAG/mg es) para los extractos crudo y etanólico. La capacidad antioxidante con el método DPPH tuvieron IC50 64,26 y 17,01 μg/mL y con el método de ABTS IC50 57,67 y 15,12 μg/mL para los extractos crudo y etanólico. La capacidad antioxidante equivalente a trolox (TEAC-DPPH) fueron 52,95 y 202,855 (μg trolox/mg es) para los extractos crudo y etanólico, la capacidad antioxidante equivalente a trolox (TEAC-ABTS) fueron 49,796 y 182,773 (μg trolox/mg es) para los extractos crudo y etanólico. Conclusiones. El extracto crudo, así como el extracto etanólico del rizoma de la Curcuma longa L. exhiben capacidad antioxidante que guardan correlación con el contenido de compuestos fenólicos.Palabras clave: Curcuma longa L.; rizoma; antioxidantes; fenoles (Fuente: DeCS)

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Genotoxic effects of PM10 and PM2.5 bound metals: metal bioaccessibility, free radical generation, and role of iron

Cited by 17 publications

References 91 publications

The Condition of Air Pollution in Kraków, Poland, in 2005–2020, with Health Risk Assessment

The Condition of Air Pollution in Kraków, Poland, in 2005–2020, with Health Risk Assessment

Advances in the Pathogenesis of Perimenopausal Syndrome

Caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.

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