Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytes <i>in vitro</i>

Akbas, Ece; Ünal, Fatma; Yüzbaşıoğlu, Deniz

doi:10.1080/01480545.2021.1957913

Cited by 2 publications

(7 citation statements)

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“…The comet assay results indicate that gadobutrol has a weak genotoxic effect on isolated lymphocytes (Akbas ¸et al, 2022).…”

Section: Genotoxic Effects Of Contrast Agentsmentioning

confidence: 96%

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

“…Mitotic index (MI) is a reproducible and sensitive parameter of cell proliferation, cytotoxicity, and cytostasis (Akbas ¸et al, 2022;Chac on et al, 2021). In a recent study, the cytotoxic effects of gadobutrol and gadoversetamide were determined by MI in human peripheral lymphocytes with the same concentrations of 7000-112,000 μg/ml (Akbas ¸et al, 2022). Both of the contrast agents resulted in decreased MI which was statistically significant at the two highest concentrations, but the decrease generated by gadoversetamide was more prominent.…”

Section: Cytotoxic Effects Of Contrast Agentsmentioning

confidence: 99%

“…The genotoxicity of chemicals can also be determined by the sister chromatid exchanges (SCEs) assay which is a simple and rapid method that indicates the genetic material exchange at homologous loci during the S phase of the cell cycle (Akbaş et al, 2022; Avuloglu‐Yilmaz et al, 2022; Yilmaz et al, 2015). SCE formation is associated with the recombinational repair, as well as point mutations, gene amplifications, and cytotoxicity (Cobanoglu & Cayir, 2021).…”

Section: Genotoxicity Testsmentioning

confidence: 99%

“…In a recent study, in vitro genotoxic effects of the same concentrations of gadobutrol and gadoversetamide were examined on human lymphocytes by CAs, SCEs, and MN tests, also comet assay for gadobutrol (Akbas et al, 2022) (Table 1). Human peripheral lymphocytes (HPLs) were treated with 7000, 14,000, 28,000, 56,000, and 112,000 μg/ml of both agents.…”

Section: Genotoxicity Testsmentioning

confidence: 99%

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Cellular toxicities of gadolinium‐based contrast agents used in magnetic resonance imaging

Akbas

Ünal

Yüzbaşıoğlu

2022

J of Applied Toxicology

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Contrast agents have been used in magnetic resonance imaging (MRI) as a radiological method. Gadolinium‐based contrast agents (GBCAs), because of their paramagnetic characteristics, are the ones mostly used in MRI to increase signal intensity. However, the use of contrast media has raised concerns on cellular toxic risks of these agents. Studies showed the accumulation of gadolinium after injection to humans with or without renal impairment. Also, there are findings obtained under in vitro and/or in vivo conditions that revealed conflicting results for their cytotoxic and genotoxic effects. Some of them declared damage in cells and genetic material; some others did not. Abnormal cell growth and genetic aberration are critical because they may lead to carcinogenesis in somatic cells or may be transferred to the next generations through germ cells. Therefore, understanding the effect of GBCAs on cells is important for their safer usage in clinical administrations to generate high‐quality contrast‐enhanced magnetic resonance images. Because of all these reasons, cellular toxicities—mainly genotoxic and cytotoxic effects—of GBCAs were reviewed in this paper.

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“…The comet assay results indicate that gadobutrol has a weak genotoxic effect on isolated lymphocytes (Akbas ¸et al, 2022).…”

Section: Genotoxic Effects Of Contrast Agentsmentioning

confidence: 96%