Genotoxic and clastogenic effects of monohaloacetic acid drinking water disinfection by-products in primary human lymphocytes

Escobar‐Hoyos, Luisa F.; Hoyos-Giraldo, Luz Stella; Londoño-Velasco, Elizabeth; Reyes-Carvajal, Ingrid; Saavedra-Trujillo, Diana; Carvajal-Varona, Silvio; Sánchez-Gómez, Adalberto; Wagner, Elizabeth D.; Plewa, Michael J.

doi:10.1016/j.watres.2013.02.052

Cited by 36 publications

(18 citation statements)

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“…Consequently, compounds with iodo-groups have enhanced mammalian cell cytotoxicity and genotoxicity, compared to their brominated and chlorinated analogues . The same pattern was also observed in both Salmonella, and in new human cell data (Attene-Ramos et al, 2010;Escobar-Hoyos et al, 2013). This epidemiology and toxicology research suggest that adverse human health effects, particularly adverse pregnancy outcomes and bladder cancer, are associated with the presence and elevated concentration of brominated DBPs Swan et al, 1998;Villanueva et al, 2004;Jeong et al, 2012;Rivera-Nunez and Wright, 2013).…”

Section: Toxicity Of Desalinated Waterssupporting

confidence: 52%

Disinfection by-product formation during seawater desalination: A review

2015

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Due to increased freshwater demand across the globe, seawater desalination has become the technology of choice in augmenting water supplies in many parts of the world. The use of chemical disinfection is necessary in desalination plants for pre-treatment to control both biofouling as well as the post-disinfection of desalinated water. Although chlorine is the most commonly used disinfectant in desalination plants, its reaction with organic matter produces various disinfection by-products (DBPs) (e.g., trihalomethanes [THMs], haloacetic acids [HAAs], and haloacetonitriles [HANs]), and some DBPs are regulated in many countries due to their potential risks to public health. To reduce the formation of chlorinated DBPs, alternative oxidants (disinfectants) such as chloramines, chlorine dioxide, and ozone can be considered, but they also produce other types of DBPs. In addition, due to high levels of bromide and iodide concentrations in seawater, highly cytotoxic and genotoxic DBP species (i.e., brominated and iodinated DBPs) may form in distribution systems, especially when desalinated water is blended with other source waters having higher levels of organic matter. This article reviews the knowledge accumulated in the last few decades on DBP formation during seawater desalination, and summarizes in detail, the occurrence of DBPs in various thermal and membrane plants involving different desalination processes. The review also identifies the current challenges and future research needs for controlling DBP formation in seawater desalination plants and to reduce the potential toxicity of desalinated water.

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Section: Toxicity Of Desalinated Waterssupporting

confidence: 52%

Disinfection by-product formation during seawater desalination: A review

2015

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“…When toxicity data were not available for a specific brominated compound, toxicity data for the closest chlorinated analogue were chosen. In this latter case, risk assessment will be minimised because it is well known that brominated byproducts are more cytotoxic and genotoxic than their resembling chlorinated compound (Richardson et al, 2007;Escobar-Hoyos et al, 2013). Statistical analyses were realised using the R software, and all the artwork was elaborated with the R and Inkscape softwares (R Core Team, 2015;Inkscape, 2015).…”

Section: Environmental Risk Assessment (Era)mentioning

confidence: 99%

Chlorination by-product concentration levels in seawater and fish of an industrialised bay (Gulf of Fos, France) exposed to multiple chlorinated effluents

Boudjellaba¹,

Dron²,

Revenko³

et al. 2016

Science of The Total Environment

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“…Research into the formation, occurrence, toxicity, epidemiology and engineering processes have resulted in enhanced interest in the adverse impact of DBPs on the environment and the public health (12,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Although the last decade experienced increased interdisciplinary collaborations amongst chemists, biologists, epidemiologists and engineers, resolving the risks of DBPs follows a dated paradigm.…”

Section: Introductionmentioning

confidence: 99%

Charting a New Path To Resolve the Adverse Health Effects of DBPs

Plewa

Wagner

2015

ACS Symposium Series

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The disinfection of drinking water was an outstanding public health achievement of the 20 th century. Disinfection by-products (DBPs) are the unintended consequence of reactions between disinfectants with organic and halide precursors in the source water. Exposure to DBPs is associated with unfavorable health effects from cancer induction to adverse pregnancy outcomes, yet the forcing agents responsible are largely unknown. Of over 600 DBPs identified, only 11 are regulated by the U.S. EPA and in many studies these are not the most toxic DBPs. Identified DBPs represent less than half of the total organic halogen in drinking water and onlỹ 80 DBPs have been evaluated by systematic quantitative toxicological analyses. Epidemiological studies are hampered by problems with exposure metrics and the suite of DBPs present in drinking water. Although the last decade experienced increased interdisciplinary collaborations amongst chemists, biologists, epidemiologists and engineers, resolving the risks of DBPs follows a dated paradigm. A new integrated approach is required to determine the contaminants in source and drinking waters that increase health risks and to provide the foundation for novel disinfection practices. We suggest the following areas in resolving adverse health effects of DBPs: 1) identification and occurrence of emerging DBPs especially iodinated-DBPs and nitrogenous-DBPs, 2) quantitative, comparative in vitro Recent Advances in Disinfection By-Products Downloaded from pubs.acs.org by 117.54.10.54 on 09/30/15. For personal use only.toxicology of DBPs and DBP classes, 3) a nationwide analysis on the toxicity of drinking waters, 4) determining the impact of DBP precursors and mixture effects on water toxicity, 5) understanding the molecular mechanisms of DBP toxicity, 6) identification of sensitive subpopulations to DBP toxicity, 7) employment of analytical chemistry and toxicity information as an essential part of epidemiological studies, and 8) engineering research on disinfection based on toxic outcomes.

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Genotoxic and clastogenic effects of monohaloacetic acid drinking water disinfection by-products in primary human lymphocytes

Cited by 36 publications

References 50 publications

Disinfection by-product formation during seawater desalination: A review

Disinfection by-product formation during seawater desalination: A review

Chlorination by-product concentration levels in seawater and fish of an industrialised bay (Gulf of Fos, France) exposed to multiple chlorinated effluents

Charting a New Path To Resolve the Adverse Health Effects of DBPs

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