Genotoxic and antigenotoxic properties of Baccharis trimera in mice

Rodrigues, Carmem Regine Faleiro; Dias, Jacqueline H.; Mello, Rodrigo; Richter, Marc François; Picada, Jaqueline Nascimento; Ferraz, Alexandre de Barros Falcão

doi:10.1016/j.jep.2009.06.006

Cited by 44 publications

(32 citation statements)

References 31 publications

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“…This report validates the previous studies which suggested that active components from plant origin are strong inhibitor of transcription factors linked to carcinogenesis [17,48]. Also, several experimental studies have demonstrated the antioxidant, anti-hepatotoxic and antigenotoxic properties of phenolic compounds in various experimental models [49][50][51]. However, in the present study, we report that PUFAs from SBEAB as endogenous hypocholesterolemic agents and inhibitors of COX-2 and iNOS expression in the small intestinal tract of diabetic rat.…”

Section: Discussionsupporting

confidence: 92%

Stem Bark Extract from Alstonia boonei attenuates Cholesterol, Triglyceride and Oxidative Damage via Low Immunohistochemical Expression in Small Intestinal Tract of Male Rats

Kehinde¹,

Adebayo²,

Oluwadamilola³

et al. 2016

J Diabetes Metab

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Stem bark extract of Alstonia boonei (SBEAB) was reported to possess anti-lipidemia, anti-microbial, antiinflammatory and anti-hypercholesterolemia properties in folk lore medicine. The present study examined the effects of SBEAB on some key lipid profiles in diabetic induced rats. Biomarkers of lipid damage, histological and immunohistochemical method were used. The expression level of cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) were also determined. SBEAB administered orally at dose of 200 mg/kg for 14 days significantly lowered the levels of cholesterol, triglyceride and malondialdehyde induced by single intraperitoneal administration of streptozotoxin (STREP) (80 mg/kg) and preserved the integrity of intestinal villi. In addition, SBEAB reduced the STREP-induced elevated activity of CAT with concomitant repression of COX-2 and iNOS expression in the intestine of diabetic rats. The protective effect of SBEAB was compared to that of metaglomide (METAG), anti-diabetic drug. Pre and post-treatment are better to prevent pro-inflammatory response and intestinal cancer in diabetic rats than METAG-administration. Taken together, the inhibition of genes programming COX-2 and iNOS expression suggest the molecular mechanism for small intestinal tract protection by SBEAB and further advocates the links between the mal-absorption of cholesterol in diabetic patients.

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Section: Discussionsupporting

confidence: 92%

Stem Bark Extract from Alstonia boonei attenuates Cholesterol, Triglyceride and Oxidative Damage via Low Immunohistochemical Expression in Small Intestinal Tract of Male Rats

Kehinde¹,

Adebayo²,

Oluwadamilola³

et al. 2016

J Diabetes Metab

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“…The protective effects could be attributed to cellular adaptive responses. This may be because apart from their capacity to scavenge free radicals, flavonoids induce the expression of genes coding for the antioxidant enzymes (Rodrigues et al, 2009). The modulatory effect of the plant extracts can also be attributed to the presence of phenolic compounds, as they are strong antioxidants (Maurich et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Genotoxic potential of Cynanchum sarcomedium Meve & Liede coupled with its modulatory action on oxidative-stress–mediatedgenotoxicity by hydrogen peroxide

BHAGYANATHAN¹,

THOPPIL²

2016

Turk J Biol

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The present study evaluated the genotoxic effect of aqueous extract of C. sarcomedium Meve & Liede and its protective role in chromosomal aberrations induced by 2% hydrogen peroxide (H 2 O 2 ) on Allium cepa root meristem. Our results showed that the C. sarcomedium extract induced major chromosomal aberrations, viz., nuclear lesions, chromosome breaks, chromosome laggards, vagrance, stickiness, and bridges. These are irreversible in nature and indicate that the plant is a potent clastogen. Total chromosome aberrations were more frequent with increase in exposure time and concentrations of plant extract. For antigenotoxic screening, three different modes of treatment were used: pretreatment, posttreatment, and simultaneous treatment. The significant induction of a wide spectrum of chromosomal aberrations and the reduction in mitotic index effected by the aqueous extract reinforced the genotoxic potential of the plant. The modulatory effect of plant extract was expressed in terms of inhibition percentage and had an excellent effect in reversing chromosomal aberrations induced by H 2 O 2 . Dose-dependent results suggest the genotoxic and antigenotoxic effect of C. sarcomedium on onion root tips. These findings offer a useful basis for further investigations on C. sarcomedium, a shrub with a broad array of prospective therapeutic activities.

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“…Being a part of the Asteraceae family [21,22], B. trimera has numerous pharmacological activities popularly attributed to their leaves, such as antiinflammatory, digestive [23], antioxidant [24], antiulcer [23,25], and antimicrobial [19,20] properties that can be helpful in the treatment of diabetes [26], rheumatism, and hepatobiliary disorders [27]. Therefore, the aim of this study was to investigate the in vitro antifungal activity of the essential oil of B. trimera against the main strains of filamentous fungi that cause onychomycosis.…”

Section: Introductionmentioning

confidence: 99%

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

Caneschi¹,

Martins²,

Larrudé³

et al. 2015

Trop. J. Pharm Res

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Genotoxic and antigenotoxic properties of Baccharis trimera in mice

Cited by 44 publications

References 31 publications

Stem Bark Extract from Alstonia boonei attenuates Cholesterol, Triglyceride and Oxidative Damage via Low Immunohistochemical Expression in Small Intestinal Tract of Male Rats

Stem Bark Extract from Alstonia boonei attenuates Cholesterol, Triglyceride and Oxidative Damage via Low Immunohistochemical Expression in Small Intestinal Tract of Male Rats

Genotoxic potential of Cynanchum sarcomedium Meve & Liede coupled with its modulatory action on oxidative-stress–mediatedgenotoxicity by hydrogen peroxide

<i>In vitro</i> Antifungal Activity of <i>Baccharis trimera</i> Less (DC) Essential Oil against Dermatophytes

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